Chemical constituents of Mussaenda erythrophylla Schumach. & Thonn. (Rubiaceae) and their chemophenetic significance

Bouzeko ILT, Dongmo FLM, Ndontsa BL, Ngansop CAN, Keumoe R, Bitchagno GTM, Jouda JB, Mbouangouere R, Tchegnitegni Toussie B, Boyom FF, Sewald N, et al. (2021)
Biochemical Systematics and Ecology 98: 104329.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Bouzeko, Inest Larissa T.; Dongmo, Faustine Leonie M.; Ndontsa, Blanche Laure; Ngansop, Cyrille Armel N.; Keumoe, Rodrigue; Bitchagno, Gabin Thierry M.; Jouda, Jean Bosco; Mbouangouere, Roukayatou; Tchegnitegni Toussie, BillyUniBi; Boyom, Fabrice Fekam; Sewald, NorbertUniBi ; Lenta, Bruno Ndjakou
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Abstract / Bemerkung
The chemical investigation of the CH2Cl2/MeOH (1:1) extract from the aerial part of Mussaenda erythrophylla Schumach. & Thonn. (Rubiaceae) resulted in the isolation of sixteen known compounds (1-16) distributed in coumarins, flavonoid glucosides, quinic acid derivatives, triterpenoids, monoglycerid, steroids, tetraterpenoid and polyol. The structures of the compounds were determined by spectrometric and spectroscopic analysis including MS and NMR data followed by their comparison with reported ones in the literature. The chemophenetic significance of the isolated compounds was discussed. The crude extract and some of the isolated compounds were assessed in vitro for their antileishmanial, cytotoxic and antiplasmodial activities. The crude extract of M. erythrophylla showed moderate antileishmanial activity (IC50 = 61.6 mu g/mL) while the hexane soluble fraction showed good antileishmanial activity (IC50 = 31.06 mu g/mL) compared to the reference drug amphotericin B (IC50 = 0.11 mu M). Compounds 11 and 9 also exhibited potent antileishmanial activity (IC50 = 53.7-52.0 mu M). The crude extract as well as the ethyl acetate soluble fraction also exhibited good antiplasmodial activity (IC50 = 7.43 +/- 0.00 mu g/mL and 14.49 +/- 2.96 mu g/mL respectively), while compounds 11, 15 and 16 showed weak activity with IC50 > 20 mu M compared to the reference drug artemisinin (IC50 = 0.014 +/- 0.001 mu M).
Stichworte
Mussaenda erythrophylla; Rubiaceae; Chemophenetic significance; Antiplasmodial activity; Antileishmanial activity; Cytotoxicity
Erscheinungsjahr
2021
Zeitschriftentitel
Biochemical Systematics and Ecology
Band
98
Art.-Nr.
104329
ISSN
0305-1978
eISSN
1873-2925
Page URI
https://pub.uni-bielefeld.de/record/2958137

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Bouzeko ILT, Dongmo FLM, Ndontsa BL, et al. Chemical constituents of Mussaenda erythrophylla Schumach. & Thonn. (Rubiaceae) and their chemophenetic significance. Biochemical Systematics and Ecology. 2021;98: 104329.
Bouzeko, I. L. T., Dongmo, F. L. M., Ndontsa, B. L., Ngansop, C. A. N., Keumoe, R., Bitchagno, G. T. M., Jouda, J. B., et al. (2021). Chemical constituents of Mussaenda erythrophylla Schumach. & Thonn. (Rubiaceae) and their chemophenetic significance. Biochemical Systematics and Ecology, 98, 104329. https://doi.org/10.1016/j.bse.2021.104329
Bouzeko, I. L. T., Dongmo, F. L. M., Ndontsa, B. L., Ngansop, C. A. N., Keumoe, R., Bitchagno, G. T. M., Jouda, J. B., Mbouangouere, R., Tchegnitegni Toussie, B., Boyom, F. F., et al. (2021). Chemical constituents of Mussaenda erythrophylla Schumach. & Thonn. (Rubiaceae) and their chemophenetic significance. Biochemical Systematics and Ecology 98:104329.
Bouzeko, I.L.T., et al., 2021. Chemical constituents of Mussaenda erythrophylla Schumach. & Thonn. (Rubiaceae) and their chemophenetic significance. Biochemical Systematics and Ecology, 98: 104329.
I.L.T. Bouzeko, et al., “Chemical constituents of Mussaenda erythrophylla Schumach. & Thonn. (Rubiaceae) and their chemophenetic significance”, Biochemical Systematics and Ecology, vol. 98, 2021, : 104329.
Bouzeko, I.L.T., Dongmo, F.L.M., Ndontsa, B.L., Ngansop, C.A.N., Keumoe, R., Bitchagno, G.T.M., Jouda, J.B., Mbouangouere, R., Tchegnitegni Toussie, B., Boyom, F.F., Sewald, N., Lenta, B.N., Tane, P., Ngouela, S.A., Tene, M.: Chemical constituents of Mussaenda erythrophylla Schumach. & Thonn. (Rubiaceae) and their chemophenetic significance. Biochemical Systematics and Ecology. 98, : 104329 (2021).
Bouzeko, Inest Larissa T., Dongmo, Faustine Leonie M., Ndontsa, Blanche Laure, Ngansop, Cyrille Armel N., Keumoe, Rodrigue, Bitchagno, Gabin Thierry M., Jouda, Jean Bosco, Mbouangouere, Roukayatou, Tchegnitegni Toussie, Billy, Boyom, Fabrice Fekam, Sewald, Norbert, Lenta, Bruno Ndjakou, Tane, Pierre, Ngouela, Silvere Augustin, and Tene, Mathieu. “Chemical constituents of Mussaenda erythrophylla Schumach. & Thonn. (Rubiaceae) and their chemophenetic significance”. Biochemical Systematics and Ecology 98 (2021): 104329.

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