Antibacterial activity of some chemical constituents from Trichilia prieuriana (Meliaceae)

Pagna JIM, Mbekou IMK, Tsamo AT, Mkounga P, Frese M, Stammler H-G, Fekam FB, Lenta BN, Sewald N, Nkengfack AE (2021)
Zeitschrift für Naturforschung B, Journal of Chemical Sciences 76(8): 439-446.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Pagna, Julio Issah Mawouma; Mbekou, Ines Michele Kanko; Tsamo, Armelle Tontsa; Mkounga, Pierre; Frese, MarcelUniBi ; Stammler, Hans-GeorgUniBi; Fekam, Fabrice Boyom; Lenta, Bruno Ndjakou; Sewald, NorbertUniBi ; Nkengfack, Augustin Ephrem
Abstract / Bemerkung
The chemical study of hydroethanolic extracts from different parts of Trichilia prieuriana (Meliaceae) led to the isolation and identification of 22 compounds: 2 beta,3 beta,4 beta-trihydroxypregnan-16-one (1), prieurianin (2), flindissone (3), deoxyflindissone (4), picraquassin E (5), ursolic acid (6), 3 beta-acetoxy-11a-hydroxyurs-12-en (7), 3 beta-acetoxy-urs-12-en-11-one (8), 3 beta-acetoxy-beta-amyrin (9), friedelin-3-ol (10), 3-oxo, friedelin (11), 3-oxo, fridelin-28-ol (12), oleanolic acid (13), hederagenin (14), mixture of stigmasterol (15), beta-sitosterol (16), beta-sitosterol-3-O-beta-glucopyranoside (17) and stigmasterol-3-O-beta-glucopyranoside (18), erythrodiol (19), scopoletin (20), 4-hydroxy-3,5-dimethoxybenzoic acid (21) and shikimic acid (22). The absolute configurations and crystal structures of compounds 1 and 2 are reported herein for the first time. Crude extracts, fractions and isolated compounds were evaluated for their antibacterial activities against nine bacterial strains. Crude extracts from the root wood of T. prieuriana exhibited good antibacterial potency with minimal inhibitory concentration (MIC) values ranging from 31.25 to 500 mu g mL(-1) on the test bacteria. The ethyl acetate fraction from root wood and n-hexane-ethyl acetate (3:1) fraction from leaves showed a moderate antibacterial activity with MIC value of 250 mu g mL(-1) on all test bacteria. Isolated compounds exhibited significant antibacterial activity with MIC values ranging from 4.09 to 71.8 mu M. Compounds 3, 6 and 7 were the most active with a broad spectrum of activities.
Stichworte
antibacterial activity; chemical constituents; limonoids; Meliaceae; steroids; Trichilia prieuriana; X-ray structure determination
Erscheinungsjahr
2021
Zeitschriftentitel
Zeitschrift für Naturforschung B, Journal of Chemical Sciences
Band
76
Ausgabe
8
Seite(n)
439-446
ISSN
0932-0776
eISSN
1865-7117
Page URI
https://pub.uni-bielefeld.de/record/2957356

Zitieren

Pagna JIM, Mbekou IMK, Tsamo AT, et al. Antibacterial activity of some chemical constituents from Trichilia prieuriana (Meliaceae). Zeitschrift für Naturforschung B, Journal of Chemical Sciences . 2021;76(8):439-446.
Pagna, J. I. M., Mbekou, I. M. K., Tsamo, A. T., Mkounga, P., Frese, M., Stammler, H. - G., Fekam, F. B., et al. (2021). Antibacterial activity of some chemical constituents from Trichilia prieuriana (Meliaceae). Zeitschrift für Naturforschung B, Journal of Chemical Sciences , 76(8), 439-446. https://doi.org/10.1515/znb-2021-0057
Pagna, J. I. M., Mbekou, I. M. K., Tsamo, A. T., Mkounga, P., Frese, M., Stammler, H. - G., Fekam, F. B., Lenta, B. N., Sewald, N., and Nkengfack, A. E. (2021). Antibacterial activity of some chemical constituents from Trichilia prieuriana (Meliaceae). Zeitschrift für Naturforschung B, Journal of Chemical Sciences 76, 439-446.
Pagna, J.I.M., et al., 2021. Antibacterial activity of some chemical constituents from Trichilia prieuriana (Meliaceae). Zeitschrift für Naturforschung B, Journal of Chemical Sciences , 76(8), p 439-446.
J.I.M. Pagna, et al., “Antibacterial activity of some chemical constituents from Trichilia prieuriana (Meliaceae)”, Zeitschrift für Naturforschung B, Journal of Chemical Sciences , vol. 76, 2021, pp. 439-446.
Pagna, J.I.M., Mbekou, I.M.K., Tsamo, A.T., Mkounga, P., Frese, M., Stammler, H.-G., Fekam, F.B., Lenta, B.N., Sewald, N., Nkengfack, A.E.: Antibacterial activity of some chemical constituents from Trichilia prieuriana (Meliaceae). Zeitschrift für Naturforschung B, Journal of Chemical Sciences . 76, 439-446 (2021).
Pagna, Julio Issah Mawouma, Mbekou, Ines Michele Kanko, Tsamo, Armelle Tontsa, Mkounga, Pierre, Frese, Marcel, Stammler, Hans-Georg, Fekam, Fabrice Boyom, Lenta, Bruno Ndjakou, Sewald, Norbert, and Nkengfack, Augustin Ephrem. “Antibacterial activity of some chemical constituents from Trichilia prieuriana (Meliaceae)”. Zeitschrift für Naturforschung B, Journal of Chemical Sciences 76.8 (2021): 439-446.

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