Neuroprotection Mediated by Human Blood Plasma in Mouse Hippocampal Slice Cultures and in Oxidatively Stressed Human Neurons

Ruiz-Perera LM, Höving AL, Schmidt KE, Cenan S, Wohllebe M, Greiner JFW, Kaltschmidt C, Simonis M, Knabbe C, Kaltschmidt B (2021)
International Journal of Molecular Sciences 22(17): 9567.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Ruiz-Perera, Lucia M.; Höving, Anna L.; Schmidt, Kazuko E.; Cenan, Sule; Wohllebe, Max; Greiner, Johannes F. W.; Kaltschmidt, ChristianUniBi; Simonis, MatthiasUniBi; Knabbe, CorneliusUniBi; Kaltschmidt, BarbaraUniBi
Abstract / Bemerkung
Neuroprotection from oxidative stress is critical during neuronal development and maintenance but also plays a major role in the pathogenesis and potential treatment of various neurological disorders and neurodegenerative diseases. Emerging evidence in the murine system suggests neuroprotective effects of blood plasma on the aged or diseased brain. However, little is known about plasma-mediated effects on human neurons. In the present study, we demonstrate the neuroprotective effect mediated by human plasma and the most abundant plasma–protein human serum albumin against oxidative stress in glutamatergic neurons differentiated from human neural crest-derived inferior turbinate stem cells. We observed a strong neuroprotective effect of human plasma and human serum albumin against oxidative stress-induced neuronal death on the single cell level, similar to the one mediated by tumor necrosis factor alpha. Moreover, we detected neuroprotection of plasma and human serum albumin against kainic acid-induced excitatory stress in ex vivo cultured mouse hippocampal tissue slices. The present study provides deeper insights into plasma-mediated neuroprotection ultimately resulting in the development of novel therapies for a variety of neurological and, in particular, neurodegenerative diseases.
Stichworte
human blood plasma; neuroprotection; oxidative stress-induced neuronal death; human serum albumin; human neural crest-derived stem cells
Erscheinungsjahr
2021
Zeitschriftentitel
International Journal of Molecular Sciences
Band
22
Ausgabe
17
Art.-Nr.
9567
eISSN
1422-0067
Finanzierungs-Informationen
Open-Access-Publikationskosten wurden durch die Universität Bielefeld gefördert.
Page URI
https://pub.uni-bielefeld.de/record/2957320

Zitieren

Ruiz-Perera LM, Höving AL, Schmidt KE, et al. Neuroprotection Mediated by Human Blood Plasma in Mouse Hippocampal Slice Cultures and in Oxidatively Stressed Human Neurons. International Journal of Molecular Sciences. 2021;22(17): 9567.
Ruiz-Perera, L. M., Höving, A. L., Schmidt, K. E., Cenan, S., Wohllebe, M., Greiner, J. F. W., Kaltschmidt, C., et al. (2021). Neuroprotection Mediated by Human Blood Plasma in Mouse Hippocampal Slice Cultures and in Oxidatively Stressed Human Neurons. International Journal of Molecular Sciences, 22(17), 9567. https://doi.org/10.3390/ijms22179567
Ruiz-Perera, L. M., Höving, A. L., Schmidt, K. E., Cenan, S., Wohllebe, M., Greiner, J. F. W., Kaltschmidt, C., Simonis, M., Knabbe, C., and Kaltschmidt, B. (2021). Neuroprotection Mediated by Human Blood Plasma in Mouse Hippocampal Slice Cultures and in Oxidatively Stressed Human Neurons. International Journal of Molecular Sciences 22:9567.
Ruiz-Perera, L.M., et al., 2021. Neuroprotection Mediated by Human Blood Plasma in Mouse Hippocampal Slice Cultures and in Oxidatively Stressed Human Neurons. International Journal of Molecular Sciences, 22(17): 9567.
L.M. Ruiz-Perera, et al., “Neuroprotection Mediated by Human Blood Plasma in Mouse Hippocampal Slice Cultures and in Oxidatively Stressed Human Neurons”, International Journal of Molecular Sciences, vol. 22, 2021, : 9567.
Ruiz-Perera, L.M., Höving, A.L., Schmidt, K.E., Cenan, S., Wohllebe, M., Greiner, J.F.W., Kaltschmidt, C., Simonis, M., Knabbe, C., Kaltschmidt, B.: Neuroprotection Mediated by Human Blood Plasma in Mouse Hippocampal Slice Cultures and in Oxidatively Stressed Human Neurons. International Journal of Molecular Sciences. 22, : 9567 (2021).
Ruiz-Perera, Lucia M., Höving, Anna L., Schmidt, Kazuko E., Cenan, Sule, Wohllebe, Max, Greiner, Johannes F. W., Kaltschmidt, Christian, Simonis, Matthias, Knabbe, Cornelius, and Kaltschmidt, Barbara. “Neuroprotection Mediated by Human Blood Plasma in Mouse Hippocampal Slice Cultures and in Oxidatively Stressed Human Neurons”. International Journal of Molecular Sciences 22.17 (2021): 9567.
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2021-09-09T10:04:14Z
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