Targeted Ablation of Primary Cilia in Differentiated Dopaminergic Neurons Reduces Striatal Dopamine and Responsiveness to Metabolic Stress

Mustafa R, Rawas C, Mannal N, Kreiner G, Spittau B, Kaminska K, Yilmaz R, Potschke C, Kirsch J, Liss B, Tucker KL, et al. (2021)
Antioxidants 10(8): 1284.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Mustafa, Rasem; Rawas, Chahinaz; Mannal, Nadja; Kreiner, Grzegorz; Spittau, BjörnUniBi; Kaminska, Katarzyna; Yilmaz, Rustem; Potschke, Christina; Kirsch, Joachim; Liss, Birgit; Tucker, Kerry L; Parlato, Rosanna
Alle
Abstract / Bemerkung
Primary cilia (PC) are microtubule-based protrusions of the cell membrane transducing molecular signals during brain development. Here, we report that PC are required for maintenance of Substantia nigra (SN) dopaminergic (DA) neurons highly vulnerable in Parkinson's disease (PD). Targeted blockage of ciliogenesis in differentiated DA neurons impaired striato-nigral integrity in adult mice. The relative number of SN DA neurons displaying a typical auto-inhibition of spontaneous activity in response to dopamine was elevated under control metabolic conditions, but not under metabolic stress. Strikingly, in the absence of PC, the remaining SN DA neurons were less vulnerable to the PD neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP). Our data indicate conserved PC-dependent neuroadaptive responses to DA lesions in the striatum. Moreover, PC control the integrity and dopamine response of a subtype of SN DA neurons. These results reinforce the critical role of PC as sensors of metabolic stress in PD and other disorders of the dopamine system.
Erscheinungsjahr
2021
Zeitschriftentitel
Antioxidants
Band
10
Ausgabe
8
Art.-Nr.
1284
eISSN
2076-3921
Page URI
https://pub.uni-bielefeld.de/record/2957243

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Mustafa R, Rawas C, Mannal N, et al. Targeted Ablation of Primary Cilia in Differentiated Dopaminergic Neurons Reduces Striatal Dopamine and Responsiveness to Metabolic Stress. Antioxidants. 2021;10(8): 1284.
Mustafa, R., Rawas, C., Mannal, N., Kreiner, G., Spittau, B., Kaminska, K., Yilmaz, R., et al. (2021). Targeted Ablation of Primary Cilia in Differentiated Dopaminergic Neurons Reduces Striatal Dopamine and Responsiveness to Metabolic Stress. Antioxidants, 10(8), 1284. https://doi.org/10.3390/antiox10081284
Mustafa, R., Rawas, C., Mannal, N., Kreiner, G., Spittau, B., Kaminska, K., Yilmaz, R., Potschke, C., Kirsch, J., Liss, B., et al. (2021). Targeted Ablation of Primary Cilia in Differentiated Dopaminergic Neurons Reduces Striatal Dopamine and Responsiveness to Metabolic Stress. Antioxidants 10:1284.
Mustafa, R., et al., 2021. Targeted Ablation of Primary Cilia in Differentiated Dopaminergic Neurons Reduces Striatal Dopamine and Responsiveness to Metabolic Stress. Antioxidants, 10(8): 1284.
R. Mustafa, et al., “Targeted Ablation of Primary Cilia in Differentiated Dopaminergic Neurons Reduces Striatal Dopamine and Responsiveness to Metabolic Stress”, Antioxidants, vol. 10, 2021, : 1284.
Mustafa, R., Rawas, C., Mannal, N., Kreiner, G., Spittau, B., Kaminska, K., Yilmaz, R., Potschke, C., Kirsch, J., Liss, B., Tucker, K.L., Parlato, R.: Targeted Ablation of Primary Cilia in Differentiated Dopaminergic Neurons Reduces Striatal Dopamine and Responsiveness to Metabolic Stress. Antioxidants. 10, : 1284 (2021).
Mustafa, Rasem, Rawas, Chahinaz, Mannal, Nadja, Kreiner, Grzegorz, Spittau, Björn, Kaminska, Katarzyna, Yilmaz, Rustem, Potschke, Christina, Kirsch, Joachim, Liss, Birgit, Tucker, Kerry L, and Parlato, Rosanna. “Targeted Ablation of Primary Cilia in Differentiated Dopaminergic Neurons Reduces Striatal Dopamine and Responsiveness to Metabolic Stress”. Antioxidants 10.8 (2021): 1284.

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