Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells

Sargsyan Y, Bickmeyer U, Gibhardt CS, Streckfuss-Bomeke K, Bogeski I, Thoms S (2021)
Life science alliance 4(9).

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Sargsyan, Yelena; Bickmeyer, Uta; Gibhardt, Christine S; Streckfuss-Bomeke, Katrin; Bogeski, Ivan; Thoms, SvenUniBi
Abstract / Bemerkung
Peroxisomes communicate with other cellular compartments by transfer of various metabolites. However, whether peroxisomes are sites for calcium handling and exchange has remained contentious. Here we generated sensors for assessment of peroxisomal calcium and applied them for single cell-based calcium imaging in HeLa cells and cardiomyocytes. We found that peroxisomes in HeLa cells take up calcium upon depletion of intracellular calcium stores and upon calcium influx across the plasma membrane. Furthermore, we show that peroxisomes of neonatal rat cardiomyocytes and human induced pluripotent stem cell-derived cardiomyocytes can take up calcium. Our results indicate that peroxisomal and cytosolic calcium signals are tightly interconnected both in HeLa cells and in cardiomyocytes. Cardiac peroxisomes take up calcium on beat-to-beat basis. Hence, peroxisomes may play an important role in shaping cellular calcium dynamics of cardiomyocytes. © 2021 Sargsyan et al.
Erscheinungsjahr
2021
Zeitschriftentitel
Life science alliance
Band
4
Ausgabe
9
eISSN
2575-1077
Finanzierungs-Informationen
Open-Access-Publikationskosten wurden durch die Universität Bielefeld gefördert.
Page URI
https://pub.uni-bielefeld.de/record/2956905

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Sargsyan Y, Bickmeyer U, Gibhardt CS, Streckfuss-Bomeke K, Bogeski I, Thoms S. Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells. Life science alliance. 2021;4(9).
Sargsyan, Y., Bickmeyer, U., Gibhardt, C. S., Streckfuss-Bomeke, K., Bogeski, I., & Thoms, S. (2021). Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells. Life science alliance, 4(9). https://doi.org/10.26508/lsa.202000987
Sargsyan, Y., Bickmeyer, U., Gibhardt, C. S., Streckfuss-Bomeke, K., Bogeski, I., and Thoms, S. (2021). Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells. Life science alliance 4.
Sargsyan, Y., et al., 2021. Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells. Life science alliance, 4(9).
Y. Sargsyan, et al., “Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells”, Life science alliance, vol. 4, 2021.
Sargsyan, Y., Bickmeyer, U., Gibhardt, C.S., Streckfuss-Bomeke, K., Bogeski, I., Thoms, S.: Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells. Life science alliance. 4, (2021).
Sargsyan, Yelena, Bickmeyer, Uta, Gibhardt, Christine S, Streckfuss-Bomeke, Katrin, Bogeski, Ivan, and Thoms, Sven. “Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells”. Life science alliance 4.9 (2021).
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2021-08-26T12:49:08Z
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