The Transcription Factor NF-κB in Stem Cells and Development

Kaltschmidt C, Greiner J, Kaltschmidt B (2021)
Cells 10(8): 2042.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
NF-κB (nuclear factor kappa B) belongs to a family of transcription factors known to regulate a broad range of processes such as immune cell function, proliferation and cancer, neuroprotection, and long-term memory. Upcoming fields of NF-κB research include its role in stem cells and developmental processes. In the present review, we discuss one role of NF-κB in development in Drosophila, Xenopus, mice, and humans in accordance with the concept of evo-devo (evolutionary developmental biology). REL domain-containing proteins of the NF-κB family are evolutionarily conserved among these species. In addition, we summarize cellular phenotypes such as defective B- and T-cell compartments related to genetic NF-κB defects detected among different species. While NF-κB proteins are present in nearly all differentiated cell types, mouse and human embryonic stem cells do not contain NF-κB proteins, potentially due to miRNA-dependent inhibition. However, the mesodermal and neuroectodermal differentiation of mouse and human embryonic stem cells is hampered upon the repression of NF-κB. We further discuss NF-κB as a crucial regulator of differentiation in adult stem cells such as neural crest-derived and mesenchymal stem cells. In particular, c-REL seems to be important for neuronal differentiation and the neuroprotection of human adult stem cells, while RELA plays a crucial role in osteogenic and mesodermal differentiation.
Stichworte
NF-κB; REL; development; adult stem cells; embryonic stem cells; differentiation
Erscheinungsjahr
2021
Zeitschriftentitel
Cells
Band
10
Ausgabe
8
Art.-Nr.
2042
eISSN
2073-4409
Finanzierungs-Informationen
Open-Access-Publikationskosten wurden durch die Universität Bielefeld gefördert.
Page URI
https://pub.uni-bielefeld.de/record/2956808

Zitieren

Kaltschmidt C, Greiner J, Kaltschmidt B. The Transcription Factor NF-κB in Stem Cells and Development. Cells. 2021;10(8): 2042.
Kaltschmidt, C., Greiner, J., & Kaltschmidt, B. (2021). The Transcription Factor NF-κB in Stem Cells and Development. Cells, 10(8), 2042. https://doi.org/10.3390/cells10082042
Kaltschmidt, C., Greiner, J., and Kaltschmidt, B. (2021). The Transcription Factor NF-κB in Stem Cells and Development. Cells 10:2042.
Kaltschmidt, C., Greiner, J., & Kaltschmidt, B., 2021. The Transcription Factor NF-κB in Stem Cells and Development. Cells, 10(8): 2042.
C. Kaltschmidt, J. Greiner, and B. Kaltschmidt, “The Transcription Factor NF-κB in Stem Cells and Development”, Cells, vol. 10, 2021, : 2042.
Kaltschmidt, C., Greiner, J., Kaltschmidt, B.: The Transcription Factor NF-κB in Stem Cells and Development. Cells. 10, : 2042 (2021).
Kaltschmidt, Christian, Greiner, Johannes, and Kaltschmidt, Barbara. “The Transcription Factor NF-κB in Stem Cells and Development”. Cells 10.8 (2021): 2042.
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2021-08-19T05:39:52Z
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