Prenylated Flavonoids and C-15 Isoprenoid Analogues with Antibacterial Properties from the Whole Plant of Imperata cylindrica (L.) Raeusch (Gramineae)
Nago R, Nayim P, Mbaveng A, Mpetga J, Bitchagno Mbahbou GT, Garandi B, Tane P, Lenta Ndjakou B, Sewald N, Tene M, Kuete V, et al. (2021)
Molecules 26(16): 4717.
Zeitschriftenaufsatz
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Autor*in
Nago, Romeo;
Nayim, Paul;
Mbaveng, Armelle;
Mpetga, James;
Bitchagno Mbahbou, Gabin ThierryUniBi;
Garandi, Badawe;
Tane, Pierre;
Lenta Ndjakou, BrunoUniBi;
Sewald, NorbertUniBi 
;
Tene, Mathieu;
Kuete, Victor;
Ngouela, Augustin
;
Tene, Mathieu;
Kuete, Victor;
Ngouela, AugustinEinrichtung
Abstract / Bemerkung
The local botanical Imperata cylindrica in Cameroon was investigated for its antibacterial potency. The methanol extract afforded a total of seven compounds, including five hitherto unreported compounds comprising three flavonoids (1–3) and two C-15 isoprenoid analogues (4 and 5) together with known derivatives (6 and 7). The novelty of the flavonoids was related to the presence of both methyl and prenyl groups. The potential origin of the methyl in the flavonoids is discussed, as well as the chemophenetic significance of our findings. Isolation was performed over repeated silica gel and Sephadex LH-20 column chromatography and the structures were elucidated by (NMR and MS). The crude methanol extract and isolated compounds showed considerable antibacterial potency against a panel of multi-drug resistant (MDR) bacterial strains. The best MIC values were obtained with compound (2) against S. aureus ATCC 25923 (32 µg/mL) and MRSA1 (16 µg/mL).
Stichworte
Imperata cylindrica;
Gramineae;
flavonoids;
terpenoids;
antibacterial properties
Erscheinungsjahr
2021
Zeitschriftentitel
Molecules
Band
26
Ausgabe
16
Art.-Nr.
4717
Urheberrecht / Lizenzen
eISSN
1420-3049
Finanzierungs-Informationen
Open-Access-Publikationskosten wurden durch die Universität Bielefeld gefördert.
Page URI
https://pub.uni-bielefeld.de/record/2956599
Zitieren
Nago R, Nayim P, Mbaveng A, et al. Prenylated Flavonoids and C-15 Isoprenoid Analogues with Antibacterial Properties from the Whole Plant of Imperata cylindrica (L.) Raeusch (Gramineae). Molecules. 2021;26(16): 4717.
Nago, R., Nayim, P., Mbaveng, A., Mpetga, J., Bitchagno Mbahbou, G. T., Garandi, B., Tane, P., et al. (2021). Prenylated Flavonoids and C-15 Isoprenoid Analogues with Antibacterial Properties from the Whole Plant of Imperata cylindrica (L.) Raeusch (Gramineae). Molecules, 26(16), 4717. https://doi.org/10.3390/molecules26164717
Nago, Romeo, Nayim, Paul, Mbaveng, Armelle, Mpetga, James, Bitchagno Mbahbou, Gabin Thierry, Garandi, Badawe, Tane, Pierre, et al. 2021. “Prenylated Flavonoids and C-15 Isoprenoid Analogues with Antibacterial Properties from the Whole Plant of Imperata cylindrica (L.) Raeusch (Gramineae)”. Molecules 26 (16): 4717.
Nago, R., Nayim, P., Mbaveng, A., Mpetga, J., Bitchagno Mbahbou, G. T., Garandi, B., Tane, P., Lenta Ndjakou, B., Sewald, N., Tene, M., et al. (2021). Prenylated Flavonoids and C-15 Isoprenoid Analogues with Antibacterial Properties from the Whole Plant of Imperata cylindrica (L.) Raeusch (Gramineae). Molecules 26:4717.
Nago, R., et al., 2021. Prenylated Flavonoids and C-15 Isoprenoid Analogues with Antibacterial Properties from the Whole Plant of Imperata cylindrica (L.) Raeusch (Gramineae). Molecules, 26(16): 4717.
R. Nago, et al., “Prenylated Flavonoids and C-15 Isoprenoid Analogues with Antibacterial Properties from the Whole Plant of Imperata cylindrica (L.) Raeusch (Gramineae)”, Molecules, vol. 26, 2021, : 4717.
Nago, R., Nayim, P., Mbaveng, A., Mpetga, J., Bitchagno Mbahbou, G.T., Garandi, B., Tane, P., Lenta Ndjakou, B., Sewald, N., Tene, M., Kuete, V., Ngouela, A.: Prenylated Flavonoids and C-15 Isoprenoid Analogues with Antibacterial Properties from the Whole Plant of Imperata cylindrica (L.) Raeusch (Gramineae). Molecules. 26, : 4717 (2021).
Nago, Romeo, Nayim, Paul, Mbaveng, Armelle, Mpetga, James, Bitchagno Mbahbou, Gabin Thierry, Garandi, Badawe, Tane, Pierre, Lenta Ndjakou, Bruno, Sewald, Norbert, Tene, Mathieu, Kuete, Victor, and Ngouela, Augustin. “Prenylated Flavonoids and C-15 Isoprenoid Analogues with Antibacterial Properties from the Whole Plant of Imperata cylindrica (L.) Raeusch (Gramineae)”. Molecules 26.16 (2021): 4717.
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