Sexual antagonism, temporally fluctuating selection, and variable dominance affect a regulatory polymorphism in Drosophila melanogaster

Glaser-Schmitt A, Wittmann M, Ramnarine TJS, Parsch J (2021)
Molecular Biology and Evolution: msab215.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Glaser-Schmitt, Amanda; Wittmann, MeikeUniBi; Ramnarine, Timothy J S; Parsch, John
Abstract / Bemerkung
Understanding how genetic variation is maintained within species is a major goal of evolutionary genetics that can shed light on the preservation of biodiversity. Here, we examined the maintenance of a regulatory single-nucleotide polymorphism (SNP) of the X-linked Drosophila melanogaster gene fezzik. The derived variant at this site is at intermediate frequency in many worldwide populations, but absent in populations from the ancestral species range in sub-Saharan Africa. We collected and genotyped wild-caught individuals from a single European population biannually over a period of five years, which revealed an overall difference in allele frequency between the sexes and a consistent change in allele frequency across seasons in females but not in males. Modelling based on the observed allele and genotype frequencies suggested that both sexually antagonistic and temporally fluctuating selection may help maintain variation at this site. The derived variant is predicted to be female-beneficial and mostly recessive; however, there was uncertainty surrounding our dominance estimates and long-term modelling projections suggest that it is more likely to be dominant. By examining gene expression phenotypes, we found that phenotypic dominance was variable and dependent upon developmental stage and genetic background, suggesting that dominance may be variable at this locus. We further determined that fezzik expression and genotype are associated with starvation resistance in a sex-dependent manner, suggesting a potential phenotypic target of selection. By characterizing the mechanisms of selection acting on this SNP, our results improve our understanding of how selection maintains genetic and phenotypic variation in natural populations. © The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
Erscheinungsjahr
2021
Zeitschriftentitel
Molecular Biology and Evolution
Art.-Nr.
msab215
ISSN
0737-4038
eISSN
1537-1719
Page URI
https://pub.uni-bielefeld.de/record/2956438

Zitieren

Glaser-Schmitt A, Wittmann M, Ramnarine TJS, Parsch J. Sexual antagonism, temporally fluctuating selection, and variable dominance affect a regulatory polymorphism in Drosophila melanogaster . Molecular Biology and Evolution. 2021: msab215.
Glaser-Schmitt, A., Wittmann, M., Ramnarine, T. J. S., & Parsch, J. (2021). Sexual antagonism, temporally fluctuating selection, and variable dominance affect a regulatory polymorphism in Drosophila melanogaster . Molecular Biology and Evolution, msab215. https://doi.org/10.1093/molbev/msab215
Glaser-Schmitt, A., Wittmann, M., Ramnarine, T. J. S., and Parsch, J. (2021). Sexual antagonism, temporally fluctuating selection, and variable dominance affect a regulatory polymorphism in Drosophila melanogaster . Molecular Biology and Evolution:msab215.
Glaser-Schmitt, A., et al., 2021. Sexual antagonism, temporally fluctuating selection, and variable dominance affect a regulatory polymorphism in Drosophila melanogaster . Molecular Biology and Evolution, : msab215.
A. Glaser-Schmitt, et al., “Sexual antagonism, temporally fluctuating selection, and variable dominance affect a regulatory polymorphism in Drosophila melanogaster ”, Molecular Biology and Evolution, 2021, : msab215.
Glaser-Schmitt, A., Wittmann, M., Ramnarine, T.J.S., Parsch, J.: Sexual antagonism, temporally fluctuating selection, and variable dominance affect a regulatory polymorphism in Drosophila melanogaster . Molecular Biology and Evolution. : msab215 (2021).
Glaser-Schmitt, Amanda, Wittmann, Meike, Ramnarine, Timothy J S, and Parsch, John. “Sexual antagonism, temporally fluctuating selection, and variable dominance affect a regulatory polymorphism in Drosophila melanogaster ”. Molecular Biology and Evolution (2021): msab215.

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