Ficusanolide A and ficusanolide B, two new cinnamic acid derivative stereoisomers and other constituents of the stem barks of Ficus exasperata Vahl. (Moraceae)

Tameye SCP, Mbeunkeu ABD, Fouokeng Y, Tameye NSJ, Tabekoueng GB, Wansi JD, Sewald N, Ndom JC, Azebaze AGB (2021)
Phytochemistry Letters 43: 150-153.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Tameye, Stevine Claudiale Popwo; Mbeunkeu, Ahri Bernie Djamen; Fouokeng, Yannick; Tameye, Nathalie Samantha Jouwa; Tabekoueng, Georges Bellier; Wansi, Jean Duplex; Sewald, NorbertUniBi ; Ndom, Jean Claude; Azebaze, Anatole Guy Blaise
Abstract / Bemerkung
Phytochemical investigation of the stem barks of Ficus exasperata Vahl. (Moraceae) led to the isolation of two new cinnamic acid derivatives stereoisomers, named ficusanolide A (1) and ficusanolide B (2) along with twelve known compounds: ficusanol (3), umbelliferone-6-carboxylic acid (4), oxypeucedanin hydrate (5), marmesin (6), decursinol (7), beta-amyrin acetate (8), lupeol (9), betulinic acid (10), ursolic acid (11), a mixture of stigmasterol (12) and beta-sitosterol (13), sitosteryl-3-O-beta-D-glucopyranoside (14); and one hemisynthetic derivative : per acetylated betulinic acid (15). Their structures were established by the means of their physical data (melting point, rotatory power), their spectroscopic data, particularly IR, NMR (1H, 13C, DEPT, COSY, HSQC and HMBC) data, and HR-ESIMS data. Crude extract, compounds 1, 2, 3, 5, 6, 7, 9, 10, 11, as well as the semisynthetic derivative 15 were evaluated for their cytotoxic activity on the human cervix carcinoma cell line KB-3-1 and the human colon cancer cell line HT-29. Ursolic acid 11 showed a moderate activity on both cancer cells tested with IC50s of 50.9 mu M and 34.4 mu M respectively.
Stichworte
Ficusanolide A; Ficusanolide B; Phytochemical analysis; Spectroscopic; techniques; Cytotoxic activity
Erscheinungsjahr
2021
Zeitschriftentitel
Phytochemistry Letters
Band
43
Seite(n)
150-153
ISSN
1874-3900
eISSN
1876-7486
Page URI
https://pub.uni-bielefeld.de/record/2956289

Zitieren

Tameye SCP, Mbeunkeu ABD, Fouokeng Y, et al. Ficusanolide A and ficusanolide B, two new cinnamic acid derivative stereoisomers and other constituents of the stem barks of Ficus exasperata Vahl. (Moraceae). Phytochemistry Letters. 2021;43:150-153.
Tameye, S. C. P., Mbeunkeu, A. B. D., Fouokeng, Y., Tameye, N. S. J., Tabekoueng, G. B., Wansi, J. D., Sewald, N., et al. (2021). Ficusanolide A and ficusanolide B, two new cinnamic acid derivative stereoisomers and other constituents of the stem barks of Ficus exasperata Vahl. (Moraceae). Phytochemistry Letters, 43, 150-153. https://doi.org/10.1016/j.phytol.2021.03.027
Tameye, S. C. P., Mbeunkeu, A. B. D., Fouokeng, Y., Tameye, N. S. J., Tabekoueng, G. B., Wansi, J. D., Sewald, N., Ndom, J. C., and Azebaze, A. G. B. (2021). Ficusanolide A and ficusanolide B, two new cinnamic acid derivative stereoisomers and other constituents of the stem barks of Ficus exasperata Vahl. (Moraceae). Phytochemistry Letters 43, 150-153.
Tameye, S.C.P., et al., 2021. Ficusanolide A and ficusanolide B, two new cinnamic acid derivative stereoisomers and other constituents of the stem barks of Ficus exasperata Vahl. (Moraceae). Phytochemistry Letters, 43, p 150-153.
S.C.P. Tameye, et al., “Ficusanolide A and ficusanolide B, two new cinnamic acid derivative stereoisomers and other constituents of the stem barks of Ficus exasperata Vahl. (Moraceae)”, Phytochemistry Letters, vol. 43, 2021, pp. 150-153.
Tameye, S.C.P., Mbeunkeu, A.B.D., Fouokeng, Y., Tameye, N.S.J., Tabekoueng, G.B., Wansi, J.D., Sewald, N., Ndom, J.C., Azebaze, A.G.B.: Ficusanolide A and ficusanolide B, two new cinnamic acid derivative stereoisomers and other constituents of the stem barks of Ficus exasperata Vahl. (Moraceae). Phytochemistry Letters. 43, 150-153 (2021).
Tameye, Stevine Claudiale Popwo, Mbeunkeu, Ahri Bernie Djamen, Fouokeng, Yannick, Tameye, Nathalie Samantha Jouwa, Tabekoueng, Georges Bellier, Wansi, Jean Duplex, Sewald, Norbert, Ndom, Jean Claude, and Azebaze, Anatole Guy Blaise. “Ficusanolide A and ficusanolide B, two new cinnamic acid derivative stereoisomers and other constituents of the stem barks of Ficus exasperata Vahl. (Moraceae)”. Phytochemistry Letters 43 (2021): 150-153.

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Suchen in

Google Scholar