Phytochemical, antibacterial, antioxidant and cytoxicity investigation of Tarenna grandiflora

Zeutsop JF, Nono RN, Frese M, Chouna JR, Lenta BN, Nkeng-Efouet-Alango P, Sewald N (2021)
Zeitschrift fur Naturforschung. C, Journal of biosciences 76(7-8): 285–290.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Zeutsop, Jean Francois; Nono, Raymond Ngansop; Frese, MarcelUniBi ; Chouna, Jean Rodolphe; Lenta, Bruno Ndjakou; Nkeng-Efouet-Alango, Pepin; Sewald, NorbertUniBi
Abstract / Bemerkung
The phytochemical investigation of Tarenna grandiflora led to the isolation of 18 known compounds ofwhich were four flavones, three anthraquinones, one phenyl propanoic derivative, five triterpenoids, four steroids and a mixture of glucose. Luteolin (1) and soranjidiol (6) were allylated and/or prenylated to give four new semisynthesized derivatives which were fully characterized as 7,3',4'-O-triallylluteolin (1a), luteolin-7,3',4'-O-triprenyls (1b), luteolin-5,7,3',4'-O-tetraprenyls (1c) and 6-O-allylsoranjidiol (6a). Their structures were established using spectroscopic analysis including 1D, 2D NMR and MS data. The cytotoxic, antioxidant and antimicrobial activities of extracts, fractions, isolated compounds and semi-synthesized derivatives were evaluated. The petroleum ether and EtOAc extracts exhibited good cytotoxic potency on KB-3-1cell line with IC50 of >0.1 and 0.025mg/mL respectively, while compounds 1b and 11 were the most active (IC50>0.0001M). Compounds 1 and 3 showed the best antioxidant activities (45.5 and 55.8M); while compounds 9 and 12 showed the best antibacterial activities with MICs values ranges from 8.55 to 132M. © 2020 Walter de Gruyter GmbH, Berlin/Boston.
Erscheinungsjahr
2021
Zeitschriftentitel
Zeitschrift fur Naturforschung. C, Journal of biosciences
Band
76
Ausgabe
7-8
Seite(n)
285–290
eISSN
1865-7125
Page URI
https://pub.uni-bielefeld.de/record/2956147

Zitieren

Zeutsop JF, Nono RN, Frese M, et al. Phytochemical, antibacterial, antioxidant and cytoxicity investigation of Tarenna grandiflora. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2021;76(7-8):285–290.
Zeutsop, J. F., Nono, R. N., Frese, M., Chouna, J. R., Lenta, B. N., Nkeng-Efouet-Alango, P., & Sewald, N. (2021). Phytochemical, antibacterial, antioxidant and cytoxicity investigation of Tarenna grandiflora. Zeitschrift fur Naturforschung. C, Journal of biosciences, 76(7-8), 285–290. https://doi.org/10.1515/znc-2020-0187
Zeutsop, J. F., Nono, R. N., Frese, M., Chouna, J. R., Lenta, B. N., Nkeng-Efouet-Alango, P., and Sewald, N. (2021). Phytochemical, antibacterial, antioxidant and cytoxicity investigation of Tarenna grandiflora. Zeitschrift fur Naturforschung. C, Journal of biosciences 76, 285–290.
Zeutsop, J.F., et al., 2021. Phytochemical, antibacterial, antioxidant and cytoxicity investigation of Tarenna grandiflora. Zeitschrift fur Naturforschung. C, Journal of biosciences, 76(7-8), p 285–290.
J.F. Zeutsop, et al., “Phytochemical, antibacterial, antioxidant and cytoxicity investigation of Tarenna grandiflora”, Zeitschrift fur Naturforschung. C, Journal of biosciences, vol. 76, 2021, pp. 285–290.
Zeutsop, J.F., Nono, R.N., Frese, M., Chouna, J.R., Lenta, B.N., Nkeng-Efouet-Alango, P., Sewald, N.: Phytochemical, antibacterial, antioxidant and cytoxicity investigation of Tarenna grandiflora. Zeitschrift fur Naturforschung. C, Journal of biosciences. 76, 285–290 (2021).
Zeutsop, Jean Francois, Nono, Raymond Ngansop, Frese, Marcel, Chouna, Jean Rodolphe, Lenta, Bruno Ndjakou, Nkeng-Efouet-Alango, Pepin, and Sewald, Norbert. “Phytochemical, antibacterial, antioxidant and cytoxicity investigation of Tarenna grandiflora”. Zeitschrift fur Naturforschung. C, Journal of biosciences 76.7-8 (2021): 285–290.

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