Chemical constituents of two Cameroonian medicinal plants: Sida rhombifolia L. and Sida acuta Burm. f. (Malvaceae) and their antiplasmodial activity

Kamdoum BC, Simo I, Wouamba SCN, Tchatat Tali BM, Ngameni B, Fotso GW, Ambassa P, Fabrice FB, Lenta BN, Sewald N, Ngadjui BT (2021)
Natural product research.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
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Autor*in
Kamdoum, Blaise Cedric; Simo, Ingrid; Wouamba, Steven Collins Njonte; Tchatat Tali, Brice Mariscal; Ngameni, Bathelemy; Fotso, Ghislain Wabo; Ambassa, Pantaleon; Fabrice, Fekam Boyom; Lenta, Bruno Ndjakou; Sewald, NorbertUniBi ; Ngadjui, Bonaventure Tchaleu
Abstract / Bemerkung
An extensive phytochemical investigation of the EtOH/H2O (7:3) extracts of Sida rhombifolia L. and Sida acuta Burm. f., yielded a previously undescribed ceramide named rhombifoliamide (1) and a xylitol dimer (2), naturally isolated here for the first time, as well as the thirteen known compounds viz, oleanolic acid (3), beta-amyrin glucoside (4), ursolic acid (5), beta-sitosterol glucoside (6), tiliroside (7), 1,6-dihydroxyxanthone (8), a mixture of stigmasterol (9) and beta-sitosterol (10), cryptolepine (11), 20-Hydroxyecdysone (12), (E)-suberenol (13), thamnosmonin (14) and xanthyletin (15). Their structures were elucidated by the analyses of their spectroscopic and spectrometric data (1D and 2D NMR, and HRESI-MS) and by comparison with the previously reported data. The crude extracts, fractions, and some isolated compounds were tested against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum strains. All the tested samples demonstrated moderate and/or significant activities against 3D7 (IC50 values: 0.18-20.11g/mL) and Dd2 (IC50 values: 0.74-63.09g/mL).
Erscheinungsjahr
2021
Zeitschriftentitel
Natural product research
eISSN
1478-6427
Page URI
https://pub.uni-bielefeld.de/record/2955914

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Kamdoum BC, Simo I, Wouamba SCN, et al. Chemical constituents of two Cameroonian medicinal plants: Sida rhombifolia L. and Sida acuta Burm. f. (Malvaceae) and their antiplasmodial activity. Natural product research. 2021.
Kamdoum, B. C., Simo, I., Wouamba, S. C. N., Tchatat Tali, B. M., Ngameni, B., Fotso, G. W., Ambassa, P., et al. (2021). Chemical constituents of two Cameroonian medicinal plants: Sida rhombifolia L. and Sida acuta Burm. f. (Malvaceae) and their antiplasmodial activity. Natural product research. https://doi.org/10.1080/14786419.2021.1937156
Kamdoum, B. C., Simo, I., Wouamba, S. C. N., Tchatat Tali, B. M., Ngameni, B., Fotso, G. W., Ambassa, P., Fabrice, F. B., Lenta, B. N., Sewald, N., et al. (2021). Chemical constituents of two Cameroonian medicinal plants: Sida rhombifolia L. and Sida acuta Burm. f. (Malvaceae) and their antiplasmodial activity. Natural product research.
Kamdoum, B.C., et al., 2021. Chemical constituents of two Cameroonian medicinal plants: Sida rhombifolia L. and Sida acuta Burm. f. (Malvaceae) and their antiplasmodial activity. Natural product research.
B.C. Kamdoum, et al., “Chemical constituents of two Cameroonian medicinal plants: Sida rhombifolia L. and Sida acuta Burm. f. (Malvaceae) and their antiplasmodial activity”, Natural product research, 2021.
Kamdoum, B.C., Simo, I., Wouamba, S.C.N., Tchatat Tali, B.M., Ngameni, B., Fotso, G.W., Ambassa, P., Fabrice, F.B., Lenta, B.N., Sewald, N., Ngadjui, B.T.: Chemical constituents of two Cameroonian medicinal plants: Sida rhombifolia L. and Sida acuta Burm. f. (Malvaceae) and their antiplasmodial activity. Natural product research. (2021).
Kamdoum, Blaise Cedric, Simo, Ingrid, Wouamba, Steven Collins Njonte, Tchatat Tali, Brice Mariscal, Ngameni, Bathelemy, Fotso, Ghislain Wabo, Ambassa, Pantaleon, Fabrice, Fekam Boyom, Lenta, Bruno Ndjakou, Sewald, Norbert, and Ngadjui, Bonaventure Tchaleu. “Chemical constituents of two Cameroonian medicinal plants: Sida rhombifolia L. and Sida acuta Burm. f. (Malvaceae) and their antiplasmodial activity”. Natural product research (2021).

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