Aerobic utilization of methanol for microbial growth and production
Wendisch VF, Kosec G, Heux S, Brautaset T (2021)
In: One-carbon Feedstocks for Sustainable Bioproduction. Zeng A-P, Claassens N (Eds); Advances in Biochemical Engineering/Biotechnology, 180. Cham: Springer : 169-212.
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| Veröffentlicht | Englisch
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Autor*in
Wendisch, Volker F.UniBi
;
Kosec, Gregor;
Heux, Stephanie;
Brautaset, Trygve
![](https://pub.uni-bielefeld.de/images/icon_orcid.png)
Herausgeber*in
Zeng, An-Ping;
Claassens, Nico
Einrichtung
Abstract / Bemerkung
Methanol is a reduced one-carbon (C1) compound. It supports growth of aerobic methylotrophs that gain ATP from reduced redox equivalents by respiratory phosphorylation in their electron transport chains. Notably, linear oxidation of methanol to carbon dioxide may yield three reduced redox equivalents if methanol oxidation is NAD-dependent as, e.g., in Bacillus methanolicus. Methanol has a higher degree of reduction per carbon than glucose (6 vs. 4), and thus, lends itself as an ideal carbon source for microbial production of reduced target compounds. However, C–C bond formation in the RuMP or serine cycle, a prerequisite for production of larger molecules, requires ATP and/or reduced redox equivalents. Moreover, heat dissipation and a high demand for oxygen during catabolic oxidation of methanol may pose challenges for fermentation processes. In this chapter, we summarize metabolic pathways for aerobic methanol utilization, aerobic methylotrophs as industrial production hosts, strain engineering, and methanol bioreactor processes. In addition, we provide technological and market outlooks.
Erscheinungsjahr
2021
Buchtitel
One-carbon Feedstocks for Sustainable Bioproduction
Serientitel
Advances in Biochemical Engineering/Biotechnology
Band
180
Seite(n)
169-212
ISBN
978-3-031-06853-9
eISBN
978-3-031-06854-6
Page URI
https://pub.uni-bielefeld.de/record/2955713
Zitieren
Wendisch VF, Kosec G, Heux S, Brautaset T. Aerobic utilization of methanol for microbial growth and production. In: Zeng A-P, Claassens N, eds. One-carbon Feedstocks for Sustainable Bioproduction. Advances in Biochemical Engineering/Biotechnology. Vol 180. Cham: Springer ; 2021: 169-212.
Wendisch, V. F., Kosec, G., Heux, S., & Brautaset, T. (2021). Aerobic utilization of methanol for microbial growth and production. In A. - P. Zeng & N. Claassens (Eds.), Advances in Biochemical Engineering/Biotechnology: Vol. 180. One-carbon Feedstocks for Sustainable Bioproduction (pp. 169-212). Cham: Springer . https://doi.org/10.1007/10_2021_177
Wendisch, Volker F., Kosec, Gregor, Heux, Stephanie, and Brautaset, Trygve. 2021. “Aerobic utilization of methanol for microbial growth and production”. In One-carbon Feedstocks for Sustainable Bioproduction, ed. An-Ping Zeng and Nico Claassens, 180:169-212. Advances in Biochemical Engineering/Biotechnology. Cham: Springer .
Wendisch, V. F., Kosec, G., Heux, S., and Brautaset, T. (2021). “Aerobic utilization of methanol for microbial growth and production” in One-carbon Feedstocks for Sustainable Bioproduction, Zeng, A. - P., and Claassens, N. eds. Advances in Biochemical Engineering/Biotechnology, vol. 180, (Cham: Springer ), 169-212.
Wendisch, V.F., et al., 2021. Aerobic utilization of methanol for microbial growth and production. In A. - P. Zeng & N. Claassens, eds. One-carbon Feedstocks for Sustainable Bioproduction. Advances in Biochemical Engineering/Biotechnology. no.180 Cham: Springer , pp. 169-212.
V.F. Wendisch, et al., “Aerobic utilization of methanol for microbial growth and production”, One-carbon Feedstocks for Sustainable Bioproduction, A.-P. Zeng and N. Claassens, eds., Advances in Biochemical Engineering/Biotechnology, vol. 180, Cham: Springer , 2021, pp.169-212.
Wendisch, V.F., Kosec, G., Heux, S., Brautaset, T.: Aerobic utilization of methanol for microbial growth and production. In: Zeng, A.-P. and Claassens, N. (eds.) One-carbon Feedstocks for Sustainable Bioproduction. Advances in Biochemical Engineering/Biotechnology. 180, p. 169-212. Springer , Cham (2021).
Wendisch, Volker F., Kosec, Gregor, Heux, Stephanie, and Brautaset, Trygve. “Aerobic utilization of methanol for microbial growth and production”. One-carbon Feedstocks for Sustainable Bioproduction. Ed. An-Ping Zeng and Nico Claassens. Cham: Springer , 2021.Vol. 180. Advances in Biochemical Engineering/Biotechnology. 169-212.
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