Chemical constituents from Baphia leptobotrys Harms (Fabaceae) and their chemophenetic significance

Wonkam AKN, Ngansop CAN, Tchuenmogne MAT, Tchegnitegni BT, Bitchagno GTM, Awantu AF, Bankeu JJK, Boyom FF, Sewald N, Lenta BN (2021)
Biochemical Systematics and Ecology 96: 104260.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Wonkam, Argan Kelly Nkwenti; Ngansop, Cyrille Armel Njanpa; Tchuenmogne, Marthe Aimee Tchuente; Tchegnitegni, Billy Toussie; Bitchagno, Gabin Thierry Mbahbou; Awantu, Angelbert Fusi; Bankeu, Jean Jules Kezetas; Boyom, Fabrice Fekam; Sewald, NorbertUniBi ; Lenta, Bruno Ndjakou
Abstract / Bemerkung
The chemical investigation of the CH2Cl2/MeOH (1:1) extract of the trunk bark and leaves of Baphia leptobotrys Harms (Fabaceae) led to the isolation of nineteen compounds (1-19). Their structures were elucidated based on the analysis of their NMR and MS data. Except for compounds 3-5, 14 and 15, all the isolated compounds are reported from the genus Baphia for the first time. Furthermore, compounds 8, 10, 16, 17 are isolated from the Fabaceae family for the first time. The crude extract and isolated compounds were screened in vitro for their antileishmanial activity against Leishmania donovani 1S (MHOM/SD/62/1S) promastigotes and cytotoxicity towards Raw 264.7 macrophage cells. The crude extract of B. leptobotrys exhibited moderate activity (IC50 = 63.40 mu g/mL). Amongst the tested compounds, ergosterol peroxide (9) and germanicol caffeoyl ester (8) exhibited good activity with IC50 values of 9.43 and 10.24 mu M, respectively and showed acceptable selectivity towards macrophage cells (SI > 3.85). The chemophenetic significance of these compounds is also discussed.
Stichworte
Baphia leptobotrys; Fabaceae; Chemophenetic significance; Antileishmanial activity; Cytotoxicity
Erscheinungsjahr
2021
Zeitschriftentitel
Biochemical Systematics and Ecology
Band
96
Art.-Nr.
104260
ISSN
0305-1978
eISSN
1873-2925
Page URI
https://pub.uni-bielefeld.de/record/2955691

Zitieren

Wonkam AKN, Ngansop CAN, Tchuenmogne MAT, et al. Chemical constituents from Baphia leptobotrys Harms (Fabaceae) and their chemophenetic significance. Biochemical Systematics and Ecology. 2021;96: 104260.
Wonkam, A. K. N., Ngansop, C. A. N., Tchuenmogne, M. A. T., Tchegnitegni, B. T., Bitchagno, G. T. M., Awantu, A. F., Bankeu, J. J. K., et al. (2021). Chemical constituents from Baphia leptobotrys Harms (Fabaceae) and their chemophenetic significance. Biochemical Systematics and Ecology, 96, 104260. https://doi.org/10.1016/j.bse.2021.104260
Wonkam, A. K. N., Ngansop, C. A. N., Tchuenmogne, M. A. T., Tchegnitegni, B. T., Bitchagno, G. T. M., Awantu, A. F., Bankeu, J. J. K., Boyom, F. F., Sewald, N., and Lenta, B. N. (2021). Chemical constituents from Baphia leptobotrys Harms (Fabaceae) and their chemophenetic significance. Biochemical Systematics and Ecology 96:104260.
Wonkam, A.K.N., et al., 2021. Chemical constituents from Baphia leptobotrys Harms (Fabaceae) and their chemophenetic significance. Biochemical Systematics and Ecology, 96: 104260.
A.K.N. Wonkam, et al., “Chemical constituents from Baphia leptobotrys Harms (Fabaceae) and their chemophenetic significance”, Biochemical Systematics and Ecology, vol. 96, 2021, : 104260.
Wonkam, A.K.N., Ngansop, C.A.N., Tchuenmogne, M.A.T., Tchegnitegni, B.T., Bitchagno, G.T.M., Awantu, A.F., Bankeu, J.J.K., Boyom, F.F., Sewald, N., Lenta, B.N.: Chemical constituents from Baphia leptobotrys Harms (Fabaceae) and their chemophenetic significance. Biochemical Systematics and Ecology. 96, : 104260 (2021).
Wonkam, Argan Kelly Nkwenti, Ngansop, Cyrille Armel Njanpa, Tchuenmogne, Marthe Aimee Tchuente, Tchegnitegni, Billy Toussie, Bitchagno, Gabin Thierry Mbahbou, Awantu, Angelbert Fusi, Bankeu, Jean Jules Kezetas, Boyom, Fabrice Fekam, Sewald, Norbert, and Lenta, Bruno Ndjakou. “Chemical constituents from Baphia leptobotrys Harms (Fabaceae) and their chemophenetic significance”. Biochemical Systematics and Ecology 96 (2021): 104260.

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Suchen in

Google Scholar