Dispersal strategies shape persistence and evolution of human gut bacteria

Hildebrand F, Goßmann T, Frioux C, Ozkurt E, Myers PN, Ferretti P, Kuhn M, Bahram M, Nielsen HB, Bork P (2021)
Cell host & microbe.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
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Autor*in
Hildebrand, Falk; Goßmann, ToniUniBi ; Frioux, Clemence; Ozkurt, Ezgi; Myers, Pernille Neve; Ferretti, Pamela; Kuhn, Michael; Bahram, Mohammad; Nielsen, Henrik Bjorn; Bork, Peer
Abstract / Bemerkung
Human gut bacterial strains can co-exist with their hosts for decades, but little is known about how these microbes persist and disperse, and evolve thereby. Here, we examined these processes in 5,278 adult and infant fecal metagenomes, longitudinally sampled in individuals and families. Our analyses revealed that a subset of gut species is extremely persistent in individuals, families, and geographic regions, represented often by locally successful strains of the phylum Bacteroidota. These "tenacious" bacteria show high levels of genetic adaptation to the human host but a high probability of loss upon antibiotic interventions. By contrast, heredipersistent bacteria, notably Firmicutes, often rely on dispersal strategies with weak phylogeographic patterns but strong family transmissions, likely related to sporulation. These analyses describe how different dispersal strategies can lead to the long-term persistence of human gut microbes with implications for gut flora modulations. Crown Copyright © 2021. Published by Elsevier Inc. All rights reserved.
Erscheinungsjahr
2021
Zeitschriftentitel
Cell host & microbe
eISSN
1934-6069
Page URI
https://pub.uni-bielefeld.de/record/2955523

Zitieren

Hildebrand F, Goßmann T, Frioux C, et al. Dispersal strategies shape persistence and evolution of human gut bacteria. Cell host & microbe. 2021.
Hildebrand, F., Goßmann, T., Frioux, C., Ozkurt, E., Myers, P. N., Ferretti, P., Kuhn, M., et al. (2021). Dispersal strategies shape persistence and evolution of human gut bacteria. Cell host & microbe. https://doi.org/10.1016/j.chom.2021.05.008
Hildebrand, F., Goßmann, T., Frioux, C., Ozkurt, E., Myers, P. N., Ferretti, P., Kuhn, M., Bahram, M., Nielsen, H. B., and Bork, P. (2021). Dispersal strategies shape persistence and evolution of human gut bacteria. Cell host & microbe.
Hildebrand, F., et al., 2021. Dispersal strategies shape persistence and evolution of human gut bacteria. Cell host & microbe.
F. Hildebrand, et al., “Dispersal strategies shape persistence and evolution of human gut bacteria”, Cell host & microbe, 2021.
Hildebrand, F., Goßmann, T., Frioux, C., Ozkurt, E., Myers, P.N., Ferretti, P., Kuhn, M., Bahram, M., Nielsen, H.B., Bork, P.: Dispersal strategies shape persistence and evolution of human gut bacteria. Cell host & microbe. (2021).
Hildebrand, Falk, Goßmann, Toni, Frioux, Clemence, Ozkurt, Ezgi, Myers, Pernille Neve, Ferretti, Pamela, Kuhn, Michael, Bahram, Mohammad, Nielsen, Henrik Bjorn, and Bork, Peer. “Dispersal strategies shape persistence and evolution of human gut bacteria”. Cell host & microbe (2021).

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PMID: 34111423
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