Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being
Wolf S, Becker J, Tsuge Y, Kawaguchi H, Kondo A, Marienhagen J, Bott M, Wendisch VF, Wittmann C (2021)
Essays in Biochemistry 65: 197–212.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Wolf, Sabrina;
Becker, Judith;
Tsuge, Yota;
Kawaguchi, Hideo;
Kondo, Akihiko;
Marienhagen, Jan;
Bott, Michael;
Wendisch, Volker F.UniBi 
;
Wittmann, Christoph
;
Wittmann, ChristophEinrichtung
Abstract / Bemerkung
The soil microbe Corynebacterium glutamicum is a leading workhorse in industrial biotechnology and has become famous for its power to synthetise amino acids and a range of bulk chemicals at high titre and yield. The product portfolio of the microbe is continuously expanding. Moreover, metabolically engineered strains of C. glutamicum produce more than 30 high value active ingredients, including signature molecules of raspberry, savoury, and orange flavours, sun blockers, anti-ageing sugars, and polymers for regenerative medicine. Herein, we highlight recent advances in engineering of the microbe into novel cell factories that overproduce these precious molecules from pioneering proofs-of-concept up to industrial productivity.
Erscheinungsjahr
2021
Zeitschriftentitel
Essays in Biochemistry
Band
65
Seite(n)
197–212
Urheberrecht / Lizenzen
ISSN
0071-1365
eISSN
1744-1358
Page URI
https://pub.uni-bielefeld.de/record/2955387
Zitieren
Wolf S, Becker J, Tsuge Y, et al. Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being. Essays in Biochemistry. 2021;65:197–212.
Wolf, S., Becker, J., Tsuge, Y., Kawaguchi, H., Kondo, A., Marienhagen, J., Bott, M., et al. (2021). Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being. Essays in Biochemistry, 65, 197–212. https://doi.org/10.1042/EBC20200134
Wolf, Sabrina, Becker, Judith, Tsuge, Yota, Kawaguchi, Hideo, Kondo, Akihiko, Marienhagen, Jan, Bott, Michael, Wendisch, Volker F., and Wittmann, Christoph. 2021. “Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being”. Essays in Biochemistry 65: 197–212.
Wolf, S., Becker, J., Tsuge, Y., Kawaguchi, H., Kondo, A., Marienhagen, J., Bott, M., Wendisch, V. F., and Wittmann, C. (2021). Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being. Essays in Biochemistry 65, 197–212.
Wolf, S., et al., 2021. Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being. Essays in Biochemistry, 65, p 197–212.
S. Wolf, et al., “Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being”, Essays in Biochemistry, vol. 65, 2021, pp. 197–212.
Wolf, S., Becker, J., Tsuge, Y., Kawaguchi, H., Kondo, A., Marienhagen, J., Bott, M., Wendisch, V.F., Wittmann, C.: Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being. Essays in Biochemistry. 65, 197–212 (2021).
Wolf, Sabrina, Becker, Judith, Tsuge, Yota, Kawaguchi, Hideo, Kondo, Akihiko, Marienhagen, Jan, Bott, Michael, Wendisch, Volker F., and Wittmann, Christoph. “Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being”. Essays in Biochemistry 65 (2021): 197–212.
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