PUB - Publikationen an der Universität Bielefeld

This retrospective matched-cohort analysis compared health-economic burdens of adults (≥18years; n=377) with phenylketonuria (PKU) and age/gender-matched non-PKU controls (n=3770) in Germany. Healthcare costs and resource-utilization were analyzed for the year 2015. Differences between groups were tested using 95% CI of mean differences (MD). PKU patients had significantly higher mean costs in total (MD 3307, 95% CI 1736-4879), for pharmaceuticals (MD 1912, 95% CI 1195-2629) [including dietary amino-acid supplements (MD 1268, 95% CI 864-1672)], and outpatient costs (MD 395, 95% CI 115-675). Inpatient costs (MD 904, 95% CI -293 to 2100) and costs for aids and remedies (MD 97, 95% CI -10 to 203) were also higher in PKU patients. PKU patients had more outpatient visits and stayed longer in hospital. Adult PKU patients incur higher total healthcare costs than non-PKU controls, especially regarding pharmaceuticals and outpatient costs, and more frequent resource-utilization, resulting in higher health-economic burden for the statutory healthcare system. © 2021 The Authors.