Two new friedelane lactones from the roots of Caloncoba glauca (Flacourtiaceae) and evaluation of their cardiotonic activity on isolated frog & rsquo;s heart

Nko'o MHJ, Noulala CGT, Tsala DE, Meva FE'ane, Sewald N, Mpondo EAM, Wansi JD, Toze FAA, Ndom JC (2021)
Phytochemistry Letters 42: 27-35.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Nko'o, Moise Henri Julien; Noulala, Cedric Guy Tchatchouang; Tsala, David Emery; Meva, Francois Eya'ane; Sewald, NorbertUniBi ; Mpondo, Emmanuel Albert Mpondo; Wansi, Jean Duplex; Toze, Flavien Aristide Alfred; Ndom, Jean Claude
Abstract / Bemerkung
Two new friedelane triterpenoids, 20,20-dimethyl-3,27-dioxo-(D:A)-friedo-olean-27,22?-lactone (20,20-dimethylglaucalactone) (1) and 3?-ethanoyloxy-30-nor-(D:A)- friedo-olean-20(29)-en-27,22?-lactone (3-acetoxyglaucalactone) (2) and four known compounds (3?6) were isolated from the methanolic extract of the roots of Caloncoba glauca (P. Beauv.) Gild (Flacourtiaceae). Their structures were determined by comprehensive spectroscopic analyses (1D and 2D NMR in addition to HRESI-MS). The relative configuration of the 22-oxymethine was determined from the NOESY spectrum. The cardiotonic effects of the crude extract and isolated compounds were tested. The results suggest that the crude extract and 3-acetoxyglaucalactone (2) induced an interesting cardiotonic activity by exerting positive inotropic and chronotropic effects, which might be derived from the direct stimulation of the 13-adrenergic pathway through 131-adrenergic receptors or opening of the calcium channel.
Stichworte
Flacourtiaceae; Caloncoba glauca; Friedelane-lactone; Cardiotonic; activity
Erscheinungsjahr
2021
Zeitschriftentitel
Phytochemistry Letters
Band
42
Seite(n)
27-35
ISSN
1874-3900
eISSN
1876-7486
Page URI
https://pub.uni-bielefeld.de/record/2954686

Zitieren

Nko'o MHJ, Noulala CGT, Tsala DE, et al. Two new friedelane lactones from the roots of Caloncoba glauca (Flacourtiaceae) and evaluation of their cardiotonic activity on isolated frog & rsquo;s heart. Phytochemistry Letters. 2021;42:27-35.
Nko'o, M. H. J., Noulala, C. G. T., Tsala, D. E., Meva, F. E. 'ane, Sewald, N., Mpondo, E. A. M., Wansi, J. D., et al. (2021). Two new friedelane lactones from the roots of Caloncoba glauca (Flacourtiaceae) and evaluation of their cardiotonic activity on isolated frog & rsquo;s heart. Phytochemistry Letters, 42, 27-35. https://doi.org/10.1016/j.phytol.2021.01.002
Nko'o, M. H. J., Noulala, C. G. T., Tsala, D. E., Meva, F. E. 'ane, Sewald, N., Mpondo, E. A. M., Wansi, J. D., Toze, F. A. A., and Ndom, J. C. (2021). Two new friedelane lactones from the roots of Caloncoba glauca (Flacourtiaceae) and evaluation of their cardiotonic activity on isolated frog & rsquo;s heart. Phytochemistry Letters 42, 27-35.
Nko'o, M.H.J., et al., 2021. Two new friedelane lactones from the roots of Caloncoba glauca (Flacourtiaceae) and evaluation of their cardiotonic activity on isolated frog & rsquo;s heart. Phytochemistry Letters, 42, p 27-35.
M.H.J. Nko'o, et al., “Two new friedelane lactones from the roots of Caloncoba glauca (Flacourtiaceae) and evaluation of their cardiotonic activity on isolated frog & rsquo;s heart”, Phytochemistry Letters, vol. 42, 2021, pp. 27-35.
Nko'o, M.H.J., Noulala, C.G.T., Tsala, D.E., Meva, F.E.'ane, Sewald, N., Mpondo, E.A.M., Wansi, J.D., Toze, F.A.A., Ndom, J.C.: Two new friedelane lactones from the roots of Caloncoba glauca (Flacourtiaceae) and evaluation of their cardiotonic activity on isolated frog & rsquo;s heart. Phytochemistry Letters. 42, 27-35 (2021).
Nko'o, Moise Henri Julien, Noulala, Cedric Guy Tchatchouang, Tsala, David Emery, Meva, Francois Eya'ane, Sewald, Norbert, Mpondo, Emmanuel Albert Mpondo, Wansi, Jean Duplex, Toze, Flavien Aristide Alfred, and Ndom, Jean Claude. “Two new friedelane lactones from the roots of Caloncoba glauca (Flacourtiaceae) and evaluation of their cardiotonic activity on isolated frog & rsquo;s heart”. Phytochemistry Letters 42 (2021): 27-35.

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