Peptidotriazolamers Inhibit Abeta(1-42) Oligomerization and Cross a Blood-Brain-Barrier Model

Tonali NM, Hericks L, Schröder DC, Kracker O, Krzemieniecki R, Kaffy J, Le Joncour V, Laakkonen P, Marion A, Ongeri S, Dodero VI, et al. (2021)
ChemPlusChem 86(6): 840-851.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Tonali, Nicolo MicheleUniBi; Hericks, LoreenUniBi; Schröder, David C.UniBi ; Kracker, OliverUniBi; Krzemieniecki, Radoslaw; Kaffy, Julia; Le Joncour, Vadim; Laakkonen, Pirjo; Marion, Antoine; Ongeri, Sandrine; Dodero, Veronica IsabelUniBi ; Sewald, NorbertUniBi
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Abstract / Bemerkung
In peptidotriazolamers every second peptide bond is replaced by a 1H-1,2,3-triazole. Such foldamers are expected to bridge the gap in molecular weight between small-molecule drugs and protein-based drugs. Amyloid beta (Abeta) aggregates play an important role in Alzheimer's disease. We studied the impact of amide bond replacements by 1,4-disubstituted 1H-1,2,3-triazoles on the inhibitory activity of the aggregation "hot spots" K16 LVFF20 and G39 VVIA42 in Abeta(1-42). We found that peptidotriazolamers act as modulators of the Abeta(1-42) oligomerization. Some peptidotriazolamers are able to interfere with the formation of toxic early Abeta oligomers, depending on the position of the triazoles, which is also supported by computational studies. Preliminary in vitro results demonstrate that a highly active peptidotriazolamer is also able to cross the blood-brain-barrier. © 2021 The Authors. ChemPlusChem published by Wiley-VCH GmbH.
Erscheinungsjahr
2021
Zeitschriftentitel
ChemPlusChem
Band
86
Ausgabe
6
Seite(n)
840-851
eISSN
2192-6506
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Open-Access-Publikationskosten wurden durch die Universität Bielefeld im Rahmen des DEAL-Vertrags gefördert.
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https://pub.uni-bielefeld.de/record/2954394

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Tonali NM, Hericks L, Schröder DC, et al. Peptidotriazolamers Inhibit Abeta(1-42) Oligomerization and Cross a Blood-Brain-Barrier Model. ChemPlusChem. 2021;86(6):840-851.
Tonali, N. M., Hericks, L., Schröder, D. C., Kracker, O., Krzemieniecki, R., Kaffy, J., Le Joncour, V., et al. (2021). Peptidotriazolamers Inhibit Abeta(1-42) Oligomerization and Cross a Blood-Brain-Barrier Model. ChemPlusChem, 86(6), 840-851. https://doi.org/10.1002/cplu.202000814
Tonali, Nicolo Michele, Hericks, Loreen, Schröder, David C., Kracker, Oliver, Krzemieniecki, Radoslaw, Kaffy, Julia, Le Joncour, Vadim, et al. 2021. “Peptidotriazolamers Inhibit Abeta(1-42) Oligomerization and Cross a Blood-Brain-Barrier Model”. ChemPlusChem 86 (6): 840-851.
Tonali, N. M., Hericks, L., Schröder, D. C., Kracker, O., Krzemieniecki, R., Kaffy, J., Le Joncour, V., Laakkonen, P., Marion, A., Ongeri, S., et al. (2021). Peptidotriazolamers Inhibit Abeta(1-42) Oligomerization and Cross a Blood-Brain-Barrier Model. ChemPlusChem 86, 840-851.
Tonali, N.M., et al., 2021. Peptidotriazolamers Inhibit Abeta(1-42) Oligomerization and Cross a Blood-Brain-Barrier Model. ChemPlusChem, 86(6), p 840-851.
N.M. Tonali, et al., “Peptidotriazolamers Inhibit Abeta(1-42) Oligomerization and Cross a Blood-Brain-Barrier Model”, ChemPlusChem, vol. 86, 2021, pp. 840-851.
Tonali, N.M., Hericks, L., Schröder, D.C., Kracker, O., Krzemieniecki, R., Kaffy, J., Le Joncour, V., Laakkonen, P., Marion, A., Ongeri, S., Dodero, V.I., Sewald, N.: Peptidotriazolamers Inhibit Abeta(1-42) Oligomerization and Cross a Blood-Brain-Barrier Model. ChemPlusChem. 86, 840-851 (2021).
Tonali, Nicolo Michele, Hericks, Loreen, Schröder, David C., Kracker, Oliver, Krzemieniecki, Radoslaw, Kaffy, Julia, Le Joncour, Vadim, Laakkonen, Pirjo, Marion, Antoine, Ongeri, Sandrine, Dodero, Veronica Isabel, and Sewald, Norbert. “Peptidotriazolamers Inhibit Abeta(1-42) Oligomerization and Cross a Blood-Brain-Barrier Model”. ChemPlusChem 86.6 (2021): 840-851.
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Material in PUB:
Dissertation, die diesen PUB Eintrag enthält
Conformational Analysis of Peptidotriazolamers and *cyclic* RGD Peptides
Schröder DC (2021)
Bielefeld: Universität Bielefeld.
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