Between Fate Choice and Self-Renewal - Heterogeneity of Adult Neural Crest-Derived Stem Cells

Höving AL, Windmöller BA, Knabbe C, Kaltschmidt B, Kaltschmidt C, Greiner J (2021)
Frontiers in Cell and Developmental Biology 9: 662754.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
OA 2.71 MB
Abstract / Bemerkung
Stem cells of the neural crest (NC) vitally participate to embryonic development, but also remain in distinct niches as quiescent neural crest-derived stem cell (NCSC) pools into adulthood. Although NCSC-populations share a high capacity for self-renewal and differentiation resulting in promising preclinical applications within the last two decades, inter- and intrapopulational differences exist in terms of their expression signatures and regenerative capability. Differentiation and self-renewal of stem cells in developmental and regenerative contexts are partially regulated by the niche or culture condition and further influenced by single cell decision processes, making cell-to-cell variation and heterogeneity critical for understanding adult stem cell populations. The present review summarizes current knowledge of the cellular heterogeneity within NCSC-populations located in distinct craniofacial and trunk niches including the nasal cavity, olfactory bulb, oral tissues or skin. We shed light on the impact of intrapopulational heterogeneity on fate specifications and plasticity of NCSCs in their nichesin vivoas well as duringin vitroculture. We further discuss underlying molecular regulators determining fate specifications of NCSCs, suggesting a regulatory network including NF-κB and NC-related transcription factors like SLUG and SOX9 accompanied by Wnt- and MAPK-signaling to orchestrate NCSC stemness and differentiation. In summary, adult NCSCs show a broad heterogeneity on the level of the donor and the donors’ sex, the cell population and the single stem cell directly impacting their differentiation capability and fate choicesin vivoandin vitro. The findings discussed here emphasize heterogeneity of NCSCs as a crucial parameter for understanding their role in tissue homeostasis and regeneration and for improving their applicability in regenerative medicine.
Erscheinungsjahr
2021
Zeitschriftentitel
Frontiers in Cell and Developmental Biology
Band
9
Art.-Nr.
662754
eISSN
2296-634X
Page URI
https://pub.uni-bielefeld.de/record/2954246

Zitieren

Höving AL, Windmöller BA, Knabbe C, Kaltschmidt B, Kaltschmidt C, Greiner J. Between Fate Choice and Self-Renewal - Heterogeneity of Adult Neural Crest-Derived Stem Cells. Frontiers in Cell and Developmental Biology. 2021;9: 662754.
Höving, A. L., Windmöller, B. A., Knabbe, C., Kaltschmidt, B., Kaltschmidt, C., & Greiner, J. (2021). Between Fate Choice and Self-Renewal - Heterogeneity of Adult Neural Crest-Derived Stem Cells. Frontiers in Cell and Developmental Biology, 9, 662754. https://doi.org/10.3389/fcell.2021.662754
Höving, A. L., Windmöller, B. A., Knabbe, C., Kaltschmidt, B., Kaltschmidt, C., and Greiner, J. (2021). Between Fate Choice and Self-Renewal - Heterogeneity of Adult Neural Crest-Derived Stem Cells. Frontiers in Cell and Developmental Biology 9:662754.
Höving, A.L., et al., 2021. Between Fate Choice and Self-Renewal - Heterogeneity of Adult Neural Crest-Derived Stem Cells. Frontiers in Cell and Developmental Biology, 9: 662754.
A.L. Höving, et al., “Between Fate Choice and Self-Renewal - Heterogeneity of Adult Neural Crest-Derived Stem Cells”, Frontiers in Cell and Developmental Biology, vol. 9, 2021, : 662754.
Höving, A.L., Windmöller, B.A., Knabbe, C., Kaltschmidt, B., Kaltschmidt, C., Greiner, J.: Between Fate Choice and Self-Renewal - Heterogeneity of Adult Neural Crest-Derived Stem Cells. Frontiers in Cell and Developmental Biology. 9, : 662754 (2021).
Höving, Anna L., Windmöller, Beatrice A., Knabbe, Cornelius, Kaltschmidt, Barbara, Kaltschmidt, Christian, and Greiner, Johannes. “Between Fate Choice and Self-Renewal - Heterogeneity of Adult Neural Crest-Derived Stem Cells”. Frontiers in Cell and Developmental Biology 9 (2021): 662754.
Alle Dateien verfügbar unter der/den folgenden Lizenz(en):
Creative Commons Namensnennung 4.0 International Public License (CC-BY 4.0):
Volltext(e)
Access Level
OA Open Access
Zuletzt Hochgeladen
2021-04-27T08:58:52Z
MD5 Prüfsumme
06d848b90655ea233f9ddb223060c7b2

Link(s) zu Volltext(en)
Access Level
OA Open Access

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 33898464
PubMed | Europe PMC

Suchen in

Google Scholar