Ablation of Vti1a/1b triggers neural progenitor pool depletion and cortical layer 5 malformation in late-embryonic mouse cortex

Sokpor G, Rosenbusch J, Kunwar AJ, Rickmann M, Tuoc T, Rizzoli SO, Tarabykin V, Fischer von Mollard G, Krieglstein K, Staiger JF (2021)
Neuroscience.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Sokpor, Godwin; Rosenbusch, Joachim; Kunwar, Ajaya J; Rickmann, Michael; Tuoc, Tran; Rizzoli, Silvio O; Tarabykin, Victor; Fischer von Mollard, GabrieleUniBi ; Krieglstein, Kerstin; Staiger, Jochen F
Abstract / Bemerkung
Cortical morphogenesis entails several neurobiological events, including proliferation and differentiation of progenitors, migration of neuroblasts, and neuronal maturation leading to functional neural circuitry. These neurodevelopmental processes are delicately regulated by many factors. Endosomal SNAREs have emerged as formidable modulators of neuronal growth, aside their well-known function in membrane/vesicular trafficking. However, our understanding of their influence on cortex formation is limited. Here, we report that the SNAREs Vti1a and Vti1b (Vti1a/1b) are critical for proper cortical development. Following null mutation of Vti1a/1b in mouse, the late-embryonic mutant cortex appeared dysgenic, and the cortical progenitors therein were depleted beyond normal. Notably, cortical layer 5 (L5) is distinctively disorganized in the absence of Vti1a/1b. The latter defect, coupled with an overt apoptosis of Ctip2-expressing L5 neurons, likely contributed to the substantial loss of corticospinal and callosal projections in the Vti1a/1b-deficient mouse brain. These findings suggest that Vti1a/1b serve key neurodevelopmental functions during cortical histogenesis, which when mechanistically elucidated, can lend clarity to how endosomal SNAREs regulate brain development, or how their dysfunction may have implications for neurological disorders. Copyright © 2021 IBRO. Published by Elsevier Ltd. All rights reserved.
Erscheinungsjahr
2021
Zeitschriftentitel
Neuroscience
eISSN
1873-7544
Page URI
https://pub.uni-bielefeld.de/record/2953582

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Sokpor G, Rosenbusch J, Kunwar AJ, et al. Ablation of Vti1a/1b triggers neural progenitor pool depletion and cortical layer 5 malformation in late-embryonic mouse cortex. Neuroscience. 2021.
Sokpor, G., Rosenbusch, J., Kunwar, A. J., Rickmann, M., Tuoc, T., Rizzoli, S. O., Tarabykin, V., et al. (2021). Ablation of Vti1a/1b triggers neural progenitor pool depletion and cortical layer 5 malformation in late-embryonic mouse cortex. Neuroscience. https://doi.org/10.1016/j.neuroscience.2021.03.021
Sokpor, G., Rosenbusch, J., Kunwar, A. J., Rickmann, M., Tuoc, T., Rizzoli, S. O., Tarabykin, V., Fischer von Mollard, G., Krieglstein, K., and Staiger, J. F. (2021). Ablation of Vti1a/1b triggers neural progenitor pool depletion and cortical layer 5 malformation in late-embryonic mouse cortex. Neuroscience.
Sokpor, G., et al., 2021. Ablation of Vti1a/1b triggers neural progenitor pool depletion and cortical layer 5 malformation in late-embryonic mouse cortex. Neuroscience.
G. Sokpor, et al., “Ablation of Vti1a/1b triggers neural progenitor pool depletion and cortical layer 5 malformation in late-embryonic mouse cortex”, Neuroscience, 2021.
Sokpor, G., Rosenbusch, J., Kunwar, A.J., Rickmann, M., Tuoc, T., Rizzoli, S.O., Tarabykin, V., Fischer von Mollard, G., Krieglstein, K., Staiger, J.F.: Ablation of Vti1a/1b triggers neural progenitor pool depletion and cortical layer 5 malformation in late-embryonic mouse cortex. Neuroscience. (2021).
Sokpor, Godwin, Rosenbusch, Joachim, Kunwar, Ajaya J, Rickmann, Michael, Tuoc, Tran, Rizzoli, Silvio O, Tarabykin, Victor, Fischer von Mollard, Gabriele, Krieglstein, Kerstin, and Staiger, Jochen F. “Ablation of Vti1a/1b triggers neural progenitor pool depletion and cortical layer 5 malformation in late-embryonic mouse cortex”. Neuroscience (2021).

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