Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment

Schulte-Schrepping J, Reusch N, Paclik D, Baßler K, Schlickeiser S, Zhang B, Krämer B, Krammer T, Brumhard S, Bonaguro L, De Domenico E, et al. (2020)
Cell 182(6): 1419-1440.e23.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Schulte-Schrepping, Jonas; Reusch, Nico; Paclik, Daniela; Baßler, Kevin; Schlickeiser, Stephan; Zhang, Bowen; Krämer, Benjamin; Krammer, Tobias; Brumhard, Sophia; Bonaguro, Lorenzo; De Domenico, Elena; Wendisch, Daniel
Alle
Abstract / Bemerkung
Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell proteomics of whole-blood and peripheral-blood mononuclear cells to determine changes in immune cell composition and activation in mild versus severe COVID-19 (242 samples from 109 individuals) over time. HLA-DRhiCD11chi inflammatory monocytes with an interferon-stimulated gene signature were elevated in mild COVID-19. Severe COVID-19 was marked by occurrence of neutrophil precursors, as evidence of emergency myelopoiesis, dysfunctional mature neutrophils, and HLA-DRlo monocytes. Our study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.
Erscheinungsjahr
2020
Zeitschriftentitel
Cell
Band
182
Ausgabe
6
Seite(n)
1419-1440.e23
ISSN
0092-8674
Page URI
https://pub.uni-bielefeld.de/record/2953267

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Schulte-Schrepping J, Reusch N, Paclik D, et al. Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. Cell. 2020;182(6):1419-1440.e23.
Schulte-Schrepping, J., Reusch, N., Paclik, D., Baßler, K., Schlickeiser, S., Zhang, B., Krämer, B., et al. (2020). Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. Cell, 182(6), 1419-1440.e23. https://doi.org/10.1016/j.cell.2020.08.001
Schulte-Schrepping, Jonas, Reusch, Nico, Paclik, Daniela, Baßler, Kevin, Schlickeiser, Stephan, Zhang, Bowen, Krämer, Benjamin, et al. 2020. “Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment”. Cell 182 (6): 1419-1440.e23.
Schulte-Schrepping, J., Reusch, N., Paclik, D., Baßler, K., Schlickeiser, S., Zhang, B., Krämer, B., Krammer, T., Brumhard, S., Bonaguro, L., et al. (2020). Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. Cell 182, 1419-1440.e23.
Schulte-Schrepping, J., et al., 2020. Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. Cell, 182(6), p 1419-1440.e23.
J. Schulte-Schrepping, et al., “Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment”, Cell, vol. 182, 2020, pp. 1419-1440.e23.
Schulte-Schrepping, J., Reusch, N., Paclik, D., Baßler, K., Schlickeiser, S., Zhang, B., Krämer, B., Krammer, T., Brumhard, S., Bonaguro, L., De Domenico, E., Wendisch, D., Grasshoff, M., Kapellos, T.S., Beckstette, M., Pecht, T., Saglam, A., Dietrich, O., Mei, H.E., Schulz, A.R., Conrad, C., Kunkel, D., Vafadarnejad, E., Xu, C.-J., Horne, A., Herbert, M., Drews, A., Thibeault, C., Pfeiffer, M., Hippenstiel, S., Hocke, A., Müller-Redetzky, H., Heim, K.-M., Machleidt, F., Uhrig, A., Bosquillon de Jarcy, L., Jürgens, L., Stegemann, M., Glösenkamp, C.R., Volk, H.-D., Goffinet, C., Landthaler, M., Wyler, E., Georg, P., Schneider, M., Dang-Heine, C., Neuwinger, N., Kappert, K., Tauber, R., Corman, V., Raabe, J., Kaiser, K.M., Vinh, M.T., Rieke, G., Meisel, C., Ulas, T., Becker, M., Geffers, R., Witzenrath, M., Drosten, C., Suttorp, N., von Kalle, C., Kurth, F., Händler, K., Schultze, J.L., Aschenbrenner, A.C., Li, Y., Nattermann, J., Sawitzki, B., Saliba, A.-E., Sander, L.E., Angelov, A., Bals, R., Bartholomäus, A., Becker, A., Bezdan, D., Bonifacio, E., Bork, P., Clavel, T., Colome-Tatche, M., Diefenbach, A., Dilthey, A., Fischer, N., Förstner, K., Frick, J.-S., Gagneur, J., Goesmann, A., Hain, T., Hummel, M., Janssen, S., Kalinowski, J., Kallies, R., Kehr, B., Keller, A., Kim-Hellmuth, S., Klein, C., Kohlbacher, O., Korbel, J.O., Kurth, I., Landthaler, M., Li, Y., Ludwig, K., Makarewicz, O., Marz, M., McHardy, A., Mertes, C., Nöthen, M., Nürnberg, P., Ohler, U., Ossowski, S., Overmann, J., Peter, S., Pfeffer, K., Poetsch, A.R., Pühler, A., Rajewsky, N., Ralser, M., Rieß, O., Ripke, S., Nunes da Rocha, U., Rosenstiel, P., Saliba, A.-E., Sander, L.E., Sawitzki, B., Schiffer, P., Schulte, E.-C., Schultze, J.L., Sczyrba, A., Stegle, O., Stoye, J., Theis, F., Vehreschild, J., Vogel, J., von Kleist, M., Walker, A., Walter, J., Wieczorek, D., Ziebuhr, J.: Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. Cell. 182, 1419-1440.e23 (2020).
Schulte-Schrepping, Jonas, Reusch, Nico, Paclik, Daniela, Baßler, Kevin, Schlickeiser, Stephan, Zhang, Bowen, Krämer, Benjamin, Krammer, Tobias, Brumhard, Sophia, Bonaguro, Lorenzo, De Domenico, Elena, Wendisch, Daniel, Grasshoff, Martin, Kapellos, Theodore S., Beckstette, Michael, Pecht, Tal, Saglam, Adem, Dietrich, Oliver, Mei, Henrik E., Schulz, Axel R., Conrad, Claudia, Kunkel, Désirée, Vafadarnejad, Ehsan, Xu, Cheng-Jian, Horne, Arik, Herbert, Miriam, Drews, Anna, Thibeault, Charlotte, Pfeiffer, Moritz, Hippenstiel, Stefan, Hocke, Andreas, Müller-Redetzky, Holger, Heim, Katrin-Moira, Machleidt, Felix, Uhrig, Alexander, Bosquillon de Jarcy, Laure, Jürgens, Linda, Stegemann, Miriam, Glösenkamp, Christoph R., Volk, Hans-Dieter, Goffinet, Christine, Landthaler, Markus, Wyler, Emanuel, Georg, Philipp, Schneider, Maria, Dang-Heine, Chantip, Neuwinger, Nick, Kappert, Kai, Tauber, Rudolf, Corman, Victor, Raabe, Jan, Kaiser, Kim Melanie, Vinh, Michael To, Rieke, Gereon, Meisel, Christian, Ulas, Thomas, Becker, Matthias, Geffers, Robert, Witzenrath, Martin, Drosten, Christian, Suttorp, Norbert, von Kalle, Christof, Kurth, Florian, Händler, Kristian, Schultze, Joachim L., Aschenbrenner, Anna C., Li, Yang, Nattermann, Jacob, Sawitzki, Birgit, Saliba, Antoine-Emmanuel, Sander, Leif Erik, Angelov, Angel, Bals, Robert, Bartholomäus, Alexander, Becker, Anke, Bezdan, Daniela, Bonifacio, Ezio, Bork, Peer, Clavel, Thomas, Colome-Tatche, Maria, Diefenbach, Andreas, Dilthey, Alexander, Fischer, Nicole, Förstner, Konrad, Frick, Julia-Stefanie, Gagneur, Julien, Goesmann, Alexander, Hain, Torsten, Hummel, Michael, Janssen, Stefan, Kalinowski, Jörn, Kallies, René, Kehr, Birte, Keller, Andreas, Kim-Hellmuth, Sarah, Klein, Christoph, Kohlbacher, Oliver, Korbel, Jan O., Kurth, Ingo, Landthaler, Markus, Li, Yang, Ludwig, Kerstin, Makarewicz, Oliwia, Marz, Manja, McHardy, Alice, Mertes, Christian, Nöthen, Markus, Nürnberg, Peter, Ohler, Uwe, Ossowski, Stephan, Overmann, Jörg, Peter, Silke, Pfeffer, Klaus, Poetsch, Anna R., Pühler, Alfred, Rajewsky, Nikolaus, Ralser, Markus, Rieß, Olaf, Ripke, Stephan, Nunes da Rocha, Ulisses, Rosenstiel, Philip, Saliba, Antoine-Emmanuel, Sander, Leif Erik, Sawitzki, Birgit, Schiffer, Philipp, Schulte, Eva-Christina, Schultze, Joachim L., Sczyrba, Alexander, Stegle, Oliver, Stoye, Jens, Theis, Fabian, Vehreschild, Janne, Vogel, Jörg, von Kleist, Max, Walker, Andreas, Walter, Jörn, Wieczorek, Dagmar, and Ziebuhr, John. “Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment”. Cell 182.6 (2020): 1419-1440.e23.
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