The Transcriptional Regulatory Network of Corynebacterium pseudotuberculosis

Parise D, Dornelles Parise MT, Pinto Gomide AC, Aburjaile FF, Kato RB, Salgado-Albarran M, Tauch A, de Carvalho Azevedo VA, Baumbach J (2021)
Microorganisms 9(2): 415.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Parise, Doglas; Dornelles Parise, Mariana Teixeira; Pinto Gomide, Anne Cybelle; Aburjaile, Flavia Figueira; Kato, Rodrigo Bentes; Salgado-Albarran, Marisol; Tauch, AndreasUniBi; de Carvalho Azevedo, Vasco Ariston; Baumbach, Jan
Abstract / Bemerkung
Corynebacterium pseudotuberculosis is a Gram-positive, facultative intracellular, pathogenic bacterium that infects several different hosts, yielding serious economic losses in livestock farming. It causes several diseases including oedematous skin disease (OSD) in buffaloes, ulcerative lymphangitis (UL) in horses, and caseous lymphadenitis (CLA) in sheep, goats and humans. Despite its economic and medical-veterinary importance, our understanding concerning this organism's transcriptional regulatory mechanisms is still limited. Here, we review the state of the art knowledge on transcriptional regulatory mechanisms of this pathogenic species, covering regulatory interactions mediated by two-component systems, transcription factors and sigma factors. Key transcriptional regulatory players involved in virulence and pathogenicity of C. pseudotuberculosis, such as the PhoPR system and DtxR, are in the focus of this review, as these regulators are promising targets for future vaccine design and drug development. We conclude that more experimental studies are needed to further understand the regulatory repertoire of this important zoonotic pathogen, and that regulators are promising targets for future vaccine design and drug development.
Stichworte
Corynebacterium pseudotuberculosis; transcriptional regulatory; mechanisms; transcription factors; two-component systems; sigma factors; virulence; pathogenicity
Erscheinungsjahr
2021
Zeitschriftentitel
Microorganisms
Band
9
Ausgabe
2
Art.-Nr.
415
eISSN
2076-2607
Page URI
https://pub.uni-bielefeld.de/record/2952732

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Parise D, Dornelles Parise MT, Pinto Gomide AC, et al. The Transcriptional Regulatory Network of Corynebacterium pseudotuberculosis. Microorganisms. 2021;9(2): 415.
Parise, D., Dornelles Parise, M. T., Pinto Gomide, A. C., Aburjaile, F. F., Kato, R. B., Salgado-Albarran, M., Tauch, A., et al. (2021). The Transcriptional Regulatory Network of Corynebacterium pseudotuberculosis. Microorganisms, 9(2), 415. https://doi.org/10.3390/microorganisms9020415
Parise, D., Dornelles Parise, M. T., Pinto Gomide, A. C., Aburjaile, F. F., Kato, R. B., Salgado-Albarran, M., Tauch, A., de Carvalho Azevedo, V. A., and Baumbach, J. (2021). The Transcriptional Regulatory Network of Corynebacterium pseudotuberculosis. Microorganisms 9:415.
Parise, D., et al., 2021. The Transcriptional Regulatory Network of Corynebacterium pseudotuberculosis. Microorganisms, 9(2): 415.
D. Parise, et al., “The Transcriptional Regulatory Network of Corynebacterium pseudotuberculosis”, Microorganisms, vol. 9, 2021, : 415.
Parise, D., Dornelles Parise, M.T., Pinto Gomide, A.C., Aburjaile, F.F., Kato, R.B., Salgado-Albarran, M., Tauch, A., de Carvalho Azevedo, V.A., Baumbach, J.: The Transcriptional Regulatory Network of Corynebacterium pseudotuberculosis. Microorganisms. 9, : 415 (2021).
Parise, Doglas, Dornelles Parise, Mariana Teixeira, Pinto Gomide, Anne Cybelle, Aburjaile, Flavia Figueira, Kato, Rodrigo Bentes, Salgado-Albarran, Marisol, Tauch, Andreas, de Carvalho Azevedo, Vasco Ariston, and Baumbach, Jan. “The Transcriptional Regulatory Network of Corynebacterium pseudotuberculosis”. Microorganisms 9.2 (2021): 415.
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2021-04-06T15:06:14Z
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