AgNOR Counts in Preneoplastic Lesions of the Bronchus

Fisseler-Eckhoff A, Becker T, Sudhoff H, Müller K-M (1994)
Pathology - Research and Practice 190(4): 389-393.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Fisseler-Eckhoff, A.; Becker, T.; Sudhoff, HolgerUniBi ; Müller, K.-M.
Abstract / Bemerkung
Silver staining of argyrophil nucleolar organizer regions (AgNORs) has become a valuable method to assess cell kinetics in paraffin sections and separate benign from malignant lesions.As a putative technique for the distinction between regenerative and preneoplastic alterations of the bronchial mucosa we employed the Ag-staining method, evaluating the number of dots/nucleus and shape of the dots.Dots/nucleus were counted by standardized methods, and mean and standard deviation were calculated.Comparative investigations were performed in bioptically obtained specimens of normal bronchial epithelium (1.94 ± 0.1 dots/nucleus, n = 12), basal cell hyperplasia (2.22 ± 0.13 dots/nucleus, n = 15); goblet cell hyperplasia (2.38 ± 0.16 dots/nucleus, n = 17), squamous cell metaplasia (2.58 ± 0.17 dots/nucleus, n = 25), squamous cell metaplasia with mild and moderate dysplasia (2.50 ± 0.5 dots/nucleus, n = 15), squamous cell metaplasia with severe dysplasia and carcinoma in situ (3.10 ± 0.47 dots/nucleus, n = 17), micropapillomatosis (2.20 ± 0.21 dots/nucleus, n = 13) and early squamous cell carcinoma of the bronchus (4.40 ± 0.74, n = 13).In preneoplastic lesions a variability in form and size of the dots was found.Though showing an increase in the number of dots/nucleus coincidentally with the degree of proliferative activity, the AgNOR method cannot be considered as a statistically significant tool in the evaluation of regenerative and preneoplastic lesions in bioptically obtained specimens.
Erscheinungsjahr
1994
Zeitschriftentitel
Pathology - Research and Practice
Band
190
Ausgabe
4
Seite(n)
389-393
ISSN
0344-0338
Page URI
https://pub.uni-bielefeld.de/record/2952044

Zitieren

Fisseler-Eckhoff A, Becker T, Sudhoff H, Müller K-M. AgNOR Counts in Preneoplastic Lesions of the Bronchus. Pathology - Research and Practice. 1994;190(4):389-393.
Fisseler-Eckhoff, A., Becker, T., Sudhoff, H., & Müller, K. - M. (1994). AgNOR Counts in Preneoplastic Lesions of the Bronchus. Pathology - Research and Practice, 190(4), 389-393. https://doi.org/10.1016/S0344-0338(11)80412-7
Fisseler-Eckhoff, A., Becker, T., Sudhoff, H., and Müller, K. - M. (1994). AgNOR Counts in Preneoplastic Lesions of the Bronchus. Pathology - Research and Practice 190, 389-393.
Fisseler-Eckhoff, A., et al., 1994. AgNOR Counts in Preneoplastic Lesions of the Bronchus. Pathology - Research and Practice, 190(4), p 389-393.
A. Fisseler-Eckhoff, et al., “AgNOR Counts in Preneoplastic Lesions of the Bronchus”, Pathology - Research and Practice, vol. 190, 1994, pp. 389-393.
Fisseler-Eckhoff, A., Becker, T., Sudhoff, H., Müller, K.-M.: AgNOR Counts in Preneoplastic Lesions of the Bronchus. Pathology - Research and Practice. 190, 389-393 (1994).
Fisseler-Eckhoff, A., Becker, T., Sudhoff, Holger, and Müller, K.-M. “AgNOR Counts in Preneoplastic Lesions of the Bronchus”. Pathology - Research and Practice 190.4 (1994): 389-393.

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Suchen in

Google Scholar