Basement Membrane in Middle Ear Cholesteatoma Immunohistochemical and Ultrastructural Observations

Bujía J, Holly A, Sudhoff H, Borkowski G, Hildmann H, Koc C, Fisseler-Eckhoff A (1996)
Annals of Otology, Rhinology & Laryngology 105(10): 804-810.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Bujía, Jesus; Holly, Anja; Sudhoff, HolgerUniBi ; Borkowski, Gerd; Hildmann, Henning; Koc, Can; Fisseler-Eckhoff, Annette
Abstract / Bemerkung
We investigated the distribution of basement membrane zone (BMZ) components collagen type IV, collagen type VII, and fibronectin in human middle ear cholesteatoma, auditory meatal skin, and middle ear mucosa using both immunohistochemical and ultrastructural methods. Collagen type IV inununoreactivity of skin and middle ear mucosa is continuous in the BMZ, whereas cholesteatoma frequently showed absent immunoreactivity or focal discontinuities. Collagen type VII inununoreactivity is detected similarly within the BMZ of cholesteatoma and skin. Fibronectin immunoreactivity is observed within the dermoepithelial junction of skin and middle ear mucosa. In cholesteatoma, however, fibronectin immunoreactivity is markedly increased within the extrinsic BMZ and the subepithelial connective tissue. The ultrastructural arrangement of the BMZ of cholesteatoma is like that of skin; however, it exhibits distinct alterations of the lamina fibroreticularis and lamina densa. Our results outline cholesteatoma as a disease with disturbed cell matrix interactions analogous to those of wound reepithelialization.
Erscheinungsjahr
1996
Zeitschriftentitel
Annals of Otology, Rhinology & Laryngology
Band
105
Ausgabe
10
Seite(n)
804-810
ISSN
0003-4894
eISSN
1943-572X
Page URI
https://pub.uni-bielefeld.de/record/2952034

Zitieren

Bujía J, Holly A, Sudhoff H, et al. Basement Membrane in Middle Ear Cholesteatoma Immunohistochemical and Ultrastructural Observations. Annals of Otology, Rhinology & Laryngology. 1996;105(10):804-810.
Bujía, J., Holly, A., Sudhoff, H., Borkowski, G., Hildmann, H., Koc, C., & Fisseler-Eckhoff, A. (1996). Basement Membrane in Middle Ear Cholesteatoma Immunohistochemical and Ultrastructural Observations. Annals of Otology, Rhinology & Laryngology, 105(10), 804-810. https://doi.org/10.1177/000348949610501008
Bujía, J., Holly, A., Sudhoff, H., Borkowski, G., Hildmann, H., Koc, C., and Fisseler-Eckhoff, A. (1996). Basement Membrane in Middle Ear Cholesteatoma Immunohistochemical and Ultrastructural Observations. Annals of Otology, Rhinology & Laryngology 105, 804-810.
Bujía, J., et al., 1996. Basement Membrane in Middle Ear Cholesteatoma Immunohistochemical and Ultrastructural Observations. Annals of Otology, Rhinology & Laryngology, 105(10), p 804-810.
J. Bujía, et al., “Basement Membrane in Middle Ear Cholesteatoma Immunohistochemical and Ultrastructural Observations”, Annals of Otology, Rhinology & Laryngology, vol. 105, 1996, pp. 804-810.
Bujía, J., Holly, A., Sudhoff, H., Borkowski, G., Hildmann, H., Koc, C., Fisseler-Eckhoff, A.: Basement Membrane in Middle Ear Cholesteatoma Immunohistochemical and Ultrastructural Observations. Annals of Otology, Rhinology & Laryngology. 105, 804-810 (1996).
Bujía, Jesus, Holly, Anja, Sudhoff, Holger, Borkowski, Gerd, Hildmann, Henning, Koc, Can, and Fisseler-Eckhoff, Annette. “Basement Membrane in Middle Ear Cholesteatoma Immunohistochemical and Ultrastructural Observations”. Annals of Otology, Rhinology & Laryngology 105.10 (1996): 804-810.

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