Zoledronic Acid Inhibits Osteoclastogenesis in Vitro and in a Mouse Model of Inflammatory Osteolysis

Sudhoff H, Faddis BT, Jung JY, Hildmann H, Ebmeyer J, Chole RA (2003)
Annals of Otology, Rhinology & Laryngology 112(9): 780-786.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Sudhoff, HolgerUniBi ; Faddis, Brian T.; Jung, Jae Y.; Hildmann, Henning; Ebmeyer, Jörg; Chole, Richard A.
Abstract / Bemerkung
This study assessed effects of the bisphosphonate zoledronic acid (ZLNA) on osteoclastogenesis. To assess the effect of ZLNA on osteoclast formation in vitro, we cultured mouse bone marrow cells under conditions that promote osteoclastogenesis. Administered at concentrations from 10−6 to 10−9 mol/L, ZLNA led to a dose-dependent inhibition of osteoclastogenesis. Combined TUNEL staining and histochemical staining for tartrate-resistant acid phosphatase showed that ZLNA induced apoptosis in osteoclasts and monocytic precursor cells. To study the effects of ZLNA in vivo, we placed keratin particles onto the surface of the parietal bone of mice to induce localized inflammatory bone resorption. Three experimental groups received daily subcutaneous injections of ZLNA (1, 3, or 10 μg/kg body weight) from 4 days before surgery until 5 days after keratin implantation. The ZLNA significantly reduced osteoclast recruitment in a dose-dependent manner, but did not affect the degree of inflammation or the mineral apposition rate.
Erscheinungsjahr
2003
Zeitschriftentitel
Annals of Otology, Rhinology & Laryngology
Band
112
Ausgabe
9
Seite(n)
780-786
ISSN
0003-4894
eISSN
1943-572X
Page URI
https://pub.uni-bielefeld.de/record/2952002

Zitieren

Sudhoff H, Faddis BT, Jung JY, Hildmann H, Ebmeyer J, Chole RA. Zoledronic Acid Inhibits Osteoclastogenesis in Vitro and in a Mouse Model of Inflammatory Osteolysis. Annals of Otology, Rhinology & Laryngology. 2003;112(9):780-786.
Sudhoff, H., Faddis, B. T., Jung, J. Y., Hildmann, H., Ebmeyer, J., & Chole, R. A. (2003). Zoledronic Acid Inhibits Osteoclastogenesis in Vitro and in a Mouse Model of Inflammatory Osteolysis. Annals of Otology, Rhinology & Laryngology, 112(9), 780-786. https://doi.org/10.1177/000348940311200907
Sudhoff, H., Faddis, B. T., Jung, J. Y., Hildmann, H., Ebmeyer, J., and Chole, R. A. (2003). Zoledronic Acid Inhibits Osteoclastogenesis in Vitro and in a Mouse Model of Inflammatory Osteolysis. Annals of Otology, Rhinology & Laryngology 112, 780-786.
Sudhoff, H., et al., 2003. Zoledronic Acid Inhibits Osteoclastogenesis in Vitro and in a Mouse Model of Inflammatory Osteolysis. Annals of Otology, Rhinology & Laryngology, 112(9), p 780-786.
H. Sudhoff, et al., “Zoledronic Acid Inhibits Osteoclastogenesis in Vitro and in a Mouse Model of Inflammatory Osteolysis”, Annals of Otology, Rhinology & Laryngology, vol. 112, 2003, pp. 780-786.
Sudhoff, H., Faddis, B.T., Jung, J.Y., Hildmann, H., Ebmeyer, J., Chole, R.A.: Zoledronic Acid Inhibits Osteoclastogenesis in Vitro and in a Mouse Model of Inflammatory Osteolysis. Annals of Otology, Rhinology & Laryngology. 112, 780-786 (2003).
Sudhoff, Holger, Faddis, Brian T., Jung, Jae Y., Hildmann, Henning, Ebmeyer, Jörg, and Chole, Richard A. “Zoledronic Acid Inhibits Osteoclastogenesis in Vitro and in a Mouse Model of Inflammatory Osteolysis”. Annals of Otology, Rhinology & Laryngology 112.9 (2003): 780-786.

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