NOD-Like Receptor Signaling in Cholesteatoma

Leichtle A, Klenke C, Ebmeyer J, Daerr M, Bruchhage K-L, Hoffmann AS, Ryan AF, Wollenberg B, Sudhoff H (2015)
BioMed Research International 2015: 408169 .

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Leichtle, Anke; Klenke, Christin; Ebmeyer, Joerg; Daerr, Markus; Bruchhage, Karl-Ludwig; Hoffmann, Anna Sophie; Ryan, Allen F.; Wollenberg, Barbara; Sudhoff, HolgerUniBi
Abstract / Bemerkung
Background. Cholesteatoma is a destructive process of the middle ear resulting in erosion of the surrounding bony structures with consequent hearing loss, vestibular dysfunction, facial paralysis, or intracranial complications. The etiopathogenesis of cholesteatoma is controversial but is associated with recurrent ear infections. The role of intracellular innate immune receptors, the NOD-like receptors, and their associated signaling networks was investigated in cholesteatoma, since mutations in NOD-like receptor-related genes have been implicated in other chronic inflammatory disorders. Results. The expression of NOD2 mRNA and protein was significantly induced in cholesteatoma compared to the external auditory canal skin, mainly located in the epithelial layer of cholesteatoma. Microarray analysis showed significant upregulation for NOD2, not for NOD1, TLR2, or TLR4 in cholesteatoma. Moreover, regulation of genes in an interaction network of the NOD-adaptor molecule RIPK2 was detected. In addition to NOD2, NLRC4, and PYCARD, the downstream molecules IRAK1 and antiapoptotic regulator CFLAR showed significant upregulation, whereas SMAD3, a proapoptotic inducer, was significantly downregulated. Finally, altered regulation of inflammatory target genes of NOD signaling was detected. Conclusions. These results indicate that the interaction of innate immune signaling mediated by NLRs and their downstream target molecules is involved in the etiopathogenesis and growth of cholesteatoma.
Erscheinungsjahr
2015
Zeitschriftentitel
BioMed Research International
Band
2015
Art.-Nr.
408169
ISSN
2314-6133
eISSN
2314-6141
Page URI
https://pub.uni-bielefeld.de/record/2951868

Zitieren

Leichtle A, Klenke C, Ebmeyer J, et al. NOD-Like Receptor Signaling in Cholesteatoma. BioMed Research International. 2015;2015: 408169 .
Leichtle, A., Klenke, C., Ebmeyer, J., Daerr, M., Bruchhage, K. - L., Hoffmann, A. S., Ryan, A. F., et al. (2015). NOD-Like Receptor Signaling in Cholesteatoma. BioMed Research International, 2015, 408169 . https://doi.org/10.1155/2015/408169
Leichtle, A., Klenke, C., Ebmeyer, J., Daerr, M., Bruchhage, K. - L., Hoffmann, A. S., Ryan, A. F., Wollenberg, B., and Sudhoff, H. (2015). NOD-Like Receptor Signaling in Cholesteatoma. BioMed Research International 2015:408169 .
Leichtle, A., et al., 2015. NOD-Like Receptor Signaling in Cholesteatoma. BioMed Research International, 2015: 408169 .
A. Leichtle, et al., “NOD-Like Receptor Signaling in Cholesteatoma”, BioMed Research International, vol. 2015, 2015, : 408169 .
Leichtle, A., Klenke, C., Ebmeyer, J., Daerr, M., Bruchhage, K.-L., Hoffmann, A.S., Ryan, A.F., Wollenberg, B., Sudhoff, H.: NOD-Like Receptor Signaling in Cholesteatoma. BioMed Research International. 2015, : 408169 (2015).
Leichtle, Anke, Klenke, Christin, Ebmeyer, Joerg, Daerr, Markus, Bruchhage, Karl-Ludwig, Hoffmann, Anna Sophie, Ryan, Allen F., Wollenberg, Barbara, and Sudhoff, Holger. “NOD-Like Receptor Signaling in Cholesteatoma”. BioMed Research International 2015 (2015): 408169 .

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