Virus-Induced Cancers of the Skin and Mucosa: Are We Dealing with “Smoking Guns” or “Smoke and Mirrors” in the Operating Theatre?

Goon PKC, Goon PKY, Tan EKH, Crawford RAF, Levell NJ, Sudhoff H (2017)
Dermatology and Therapy 7(2): 249-254.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Goon, Peter K. C.; Goon, Patrick K. Y.; Tan, Eunice K. H.; Crawford, Robin A. F.; Levell, Nick J.; Sudhoff, HolgerUniBi
Abstract / Bemerkung
#### Introduction Human papillomavirus (HPV) alone is thought to cause ~610,000 cases of cancer per year, and is the dominant aetiological agent for ano-genital (esp. cervical) and head and neck cancers (esp. oropharyngeal). Merkel cell polyomavirus (MCV) is a more recently discovered virus which causes Merkel cell carcinoma, a rare but highly aggressive skin malignancy. #### Methods We explored the available published evidence to see if transmission of live HPV or MCV virus in smoke generated by laser or diathermy was feasible, and would pose an infection risk. Long-term infection with such carcinogenic viruses would then pose an increased risk for the development of virus-induced cancers in medical personnel. #### Results The morphological structures of both HPV and MCV are very similar, and the size, external capsids and genomic structures show striking similarity. Both viruses have a non-enveloped external protein capsid consisting of 72 capsomeres, and a double-stranded DNA core. Sizes of both viruses range from 50 to 60 nm. There are now recent data demonstrating live and infectious HPV in smoke, and that these viruses can be used to infect cells in vitro. Further, anecdotal reports of virus transmission leading to disease causation in the production of respiratory airway viral warts (benign disease), and, finally, reports of HPV-induced oropharyngeal carcinoma (malignant disease) in two gynaecological surgeons as an occupational health hazard have been published recently. #### Conclusion There is now sufficient evidence to support the hypotheses that live infectious carcinogenic viruses can be transmitted via smoke generated from surgical procedures, and, in rare instances, actually cause significant disease. Protective measures such as smoke extraction and airway protection should be instituted for all healthcare personnel, particularly those with multiple repeated exposures such as gynaecological surgeons.
Erscheinungsjahr
2017
Zeitschriftentitel
Dermatology and Therapy
Band
7
Ausgabe
2
Seite(n)
249-254
ISSN
2193-8210
eISSN
2190-9172
Page URI
https://pub.uni-bielefeld.de/record/2951851

Zitieren

Goon PKC, Goon PKY, Tan EKH, Crawford RAF, Levell NJ, Sudhoff H. Virus-Induced Cancers of the Skin and Mucosa: Are We Dealing with “Smoking Guns” or “Smoke and Mirrors” in the Operating Theatre? Dermatology and Therapy. 2017;7(2):249-254.
Goon, P. K. C., Goon, P. K. Y., Tan, E. K. H., Crawford, R. A. F., Levell, N. J., & Sudhoff, H. (2017). Virus-Induced Cancers of the Skin and Mucosa: Are We Dealing with “Smoking Guns” or “Smoke and Mirrors” in the Operating Theatre? Dermatology and Therapy, 7(2), 249-254. https://doi.org/10.1007/s13555-017-0182-5
Goon, P. K. C., Goon, P. K. Y., Tan, E. K. H., Crawford, R. A. F., Levell, N. J., and Sudhoff, H. (2017). Virus-Induced Cancers of the Skin and Mucosa: Are We Dealing with “Smoking Guns” or “Smoke and Mirrors” in the Operating Theatre? Dermatology and Therapy 7, 249-254.
Goon, P.K.C., et al., 2017. Virus-Induced Cancers of the Skin and Mucosa: Are We Dealing with “Smoking Guns” or “Smoke and Mirrors” in the Operating Theatre? Dermatology and Therapy, 7(2), p 249-254.
P.K.C. Goon, et al., “Virus-Induced Cancers of the Skin and Mucosa: Are We Dealing with “Smoking Guns” or “Smoke and Mirrors” in the Operating Theatre?”, Dermatology and Therapy, vol. 7, 2017, pp. 249-254.
Goon, P.K.C., Goon, P.K.Y., Tan, E.K.H., Crawford, R.A.F., Levell, N.J., Sudhoff, H.: Virus-Induced Cancers of the Skin and Mucosa: Are We Dealing with “Smoking Guns” or “Smoke and Mirrors” in the Operating Theatre? Dermatology and Therapy. 7, 249-254 (2017).
Goon, Peter K. C., Goon, Patrick K. Y., Tan, Eunice K. H., Crawford, Robin A. F., Levell, Nick J., and Sudhoff, Holger. “Virus-Induced Cancers of the Skin and Mucosa: Are We Dealing with “Smoking Guns” or “Smoke and Mirrors” in the Operating Theatre?”. Dermatology and Therapy 7.2 (2017): 249-254.

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