Rothmanniamide and other constituents from the leaves of Rothmannia hispida (K.Schum.) fagerl. (Rubiaceae) and their chemophenetic significance

Wonkam AKN, Ngansop CAN, Wouamba SCN, Jouda JB, Happi Mouthe G, Boyom FF, Sewald N, Lenta BN (2020)
Biochemical Systematics and Ecology 93: 104137.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Wonkam, Argan Kelly Nkwenti; Ngansop, Cyrille Armel Njanpa; Wouamba, Steven Collins Njonte; Jouda, Jean Bosco; Happi Mouthe, GervaisUniBi; Boyom, Fabrice Fekam; Sewald, NorbertUniBi ; Lenta, Bruno Ndjakou
Abstract / Bemerkung
The chemical investigation of the CH2Cl2/MeOH (1:1) extract of the leaves of Rothmannia hispida (K. Schum.) Fagerl. (Rubiaceae) led to the isolation of a new ceramide rothmanniamide (1) and a naturally isolated alkyl cinnamate derivative n-heptadecyl-4-hydroxy-trans-cinnamate (2), along with fifteen known compounds including lupeol palmitate (3), lupeol (4), a mixture of uvaol (5) and erythrodiol (6), ursolic acid (7), 30-nor2 alpha,3 beta-dihydroxyurs-12-ene (8), hederagenin (9), stigmast-22-en-3-ol (10), a mixture of beta-sitosterol (11) and stigmasterol (12), stigmast-4,22-dien-3-ol (13), stigmasterol 3-O-beta-D-glucoside (14), triacontan-1-ol (15), kaempferol 3-O-beta-D-glucopyranoside (16) and D-mannitol (17). Their structures were elucidated with the help of MS and NMR data. Compounds 8, 10 and 15 were isolated for the first time from the Rubiaceae family. The crude extract and the isolates were assessed in vitro for their antileishmanial activity against Leishmania donovani 1 S (MHOM/SD/62/1 S) promastigotes and cytotoxicity on RAW 264.7 macrophage cells. Compounds 7 and 8 exhibited a highly potent antileishmanial activity with IC50 values of 0.88 and 1.75 mu g/mL, respectively, with good selectivity indexes (SI > 57). The chemophenetic significance of these compounds is also discussed.
Stichworte
Rothmannia hispida; Rubiaceae; Chemophenetic significance; Rothmanniamide; Alkyl cinnamate; Antileishmanial
Erscheinungsjahr
2020
Zeitschriftentitel
Biochemical Systematics and Ecology
Band
93
Art.-Nr.
104137
ISSN
0305-1978
eISSN
1873-2925
Page URI
https://pub.uni-bielefeld.de/record/2950232

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Wonkam AKN, Ngansop CAN, Wouamba SCN, et al. Rothmanniamide and other constituents from the leaves of Rothmannia hispida (K.Schum.) fagerl. (Rubiaceae) and their chemophenetic significance. Biochemical Systematics and Ecology. 2020;93: 104137.
Wonkam, A. K. N., Ngansop, C. A. N., Wouamba, S. C. N., Jouda, J. B., Happi Mouthe, G., Boyom, F. F., Sewald, N., et al. (2020). Rothmanniamide and other constituents from the leaves of Rothmannia hispida (K.Schum.) fagerl. (Rubiaceae) and their chemophenetic significance. Biochemical Systematics and Ecology, 93, 104137. doi:10.1016/j.bse.2020.104137
Wonkam, A. K. N., Ngansop, C. A. N., Wouamba, S. C. N., Jouda, J. B., Happi Mouthe, G., Boyom, F. F., Sewald, N., and Lenta, B. N. (2020). Rothmanniamide and other constituents from the leaves of Rothmannia hispida (K.Schum.) fagerl. (Rubiaceae) and their chemophenetic significance. Biochemical Systematics and Ecology 93:104137.
Wonkam, A.K.N., et al., 2020. Rothmanniamide and other constituents from the leaves of Rothmannia hispida (K.Schum.) fagerl. (Rubiaceae) and their chemophenetic significance. Biochemical Systematics and Ecology, 93: 104137.
A.K.N. Wonkam, et al., “Rothmanniamide and other constituents from the leaves of Rothmannia hispida (K.Schum.) fagerl. (Rubiaceae) and their chemophenetic significance”, Biochemical Systematics and Ecology, vol. 93, 2020, : 104137.
Wonkam, A.K.N., Ngansop, C.A.N., Wouamba, S.C.N., Jouda, J.B., Happi Mouthe, G., Boyom, F.F., Sewald, N., Lenta, B.N.: Rothmanniamide and other constituents from the leaves of Rothmannia hispida (K.Schum.) fagerl. (Rubiaceae) and their chemophenetic significance. Biochemical Systematics and Ecology. 93, : 104137 (2020).
Wonkam, Argan Kelly Nkwenti, Ngansop, Cyrille Armel Njanpa, Wouamba, Steven Collins Njonte, Jouda, Jean Bosco, Happi Mouthe, Gervais, Boyom, Fabrice Fekam, Sewald, Norbert, and Lenta, Bruno Ndjakou. “Rothmanniamide and other constituents from the leaves of Rothmannia hispida (K.Schum.) fagerl. (Rubiaceae) and their chemophenetic significance”. Biochemical Systematics and Ecology 93 (2020): 104137.

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