Statistical methods for spatial cluster detection in childhood cancer incidence: A simulation study.
Schundeln MM, Lange T, Knoll M, Spix C, Brenner H, Bozorgmehr K, Stock C (2020)
Cancer epidemiology 70: 101873.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Schundeln, Michael M;
Lange, Toni;
Knoll, Maximilian;
Spix, Claudia;
Brenner, Hermann;
Bozorgmehr, KayvanUniBi
;
Stock, Christian
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Einrichtung
Abstract / Bemerkung
BACKGROUND AND OBJECTIVE: The potential existence of spatial clusters in childhood cancer incidence is a debated topic. Identification of such clusters may help to better understand etiology and develop preventive strategies. We evaluated widely used statistical approaches to cluster detection in this context.; METHODS: Incidence of newly diagnosed childhood cancer (140/1,000,000 children under 15 years) and nephroblastoma (7/1,000,000) was simulated. Clusters of defined size (1-50) were randomly assembled on the district level in Germany. Each cluster was simulated with different relative risk levels (1-100). For each combination 2000 iterations were done. Simulated data was then analyzed by three local clustering tests: Besag-Newell method, spatial scan statistic and Bayesian Besag-York-Mollie with Integrated Nested Laplace Approximation approach. The operating characteristics (sensitivity, specificity, predictive values, power and correct classification) of all three methods were systematically described.; RESULTS: Performance varied considerably within and between methods, depending on the simulated setting. Sensitivity of all methods was positively associated with increasing size, incidence and RR of the high-risk area. Besag-York-Mollie showed highest specificity for minimally increased RR in most scenarios. The performance of all methods was lower in the nephroblastoma scenario compared with the scenario including all cancer cases.; CONCLUSION: This study illustrates the challenge to make reliable inferences on the existence of spatial clusters based on single statistical approaches in childhood cancer. Application of multiple methods, ideally with known operating characteristics, and a critical discussion of the joint evidence seems recommendable when aiming to identify high-risk clusters. Copyright © 2020 Elsevier Ltd. All rights reserved.
Erscheinungsjahr
2020
Zeitschriftentitel
Cancer epidemiology
Band
70
Art.-Nr.
101873
eISSN
1877-783X
Page URI
https://pub.uni-bielefeld.de/record/2949969
Zitieren
Schundeln MM, Lange T, Knoll M, et al. Statistical methods for spatial cluster detection in childhood cancer incidence: A simulation study. Cancer epidemiology. 2020;70: 101873.
Schundeln, M. M., Lange, T., Knoll, M., Spix, C., Brenner, H., Bozorgmehr, K., & Stock, C. (2020). Statistical methods for spatial cluster detection in childhood cancer incidence: A simulation study. Cancer epidemiology, 70, 101873. https://doi.org/10.1016/j.canep.2020.101873
Schundeln, Michael M, Lange, Toni, Knoll, Maximilian, Spix, Claudia, Brenner, Hermann, Bozorgmehr, Kayvan, and Stock, Christian. 2020. “Statistical methods for spatial cluster detection in childhood cancer incidence: A simulation study.”. Cancer epidemiology 70: 101873.
Schundeln, M. M., Lange, T., Knoll, M., Spix, C., Brenner, H., Bozorgmehr, K., and Stock, C. (2020). Statistical methods for spatial cluster detection in childhood cancer incidence: A simulation study. Cancer epidemiology 70:101873.
Schundeln, M.M., et al., 2020. Statistical methods for spatial cluster detection in childhood cancer incidence: A simulation study. Cancer epidemiology, 70: 101873.
M.M. Schundeln, et al., “Statistical methods for spatial cluster detection in childhood cancer incidence: A simulation study.”, Cancer epidemiology, vol. 70, 2020, : 101873.
Schundeln, M.M., Lange, T., Knoll, M., Spix, C., Brenner, H., Bozorgmehr, K., Stock, C.: Statistical methods for spatial cluster detection in childhood cancer incidence: A simulation study. Cancer epidemiology. 70, : 101873 (2020).
Schundeln, Michael M, Lange, Toni, Knoll, Maximilian, Spix, Claudia, Brenner, Hermann, Bozorgmehr, Kayvan, and Stock, Christian. “Statistical methods for spatial cluster detection in childhood cancer incidence: A simulation study.”. Cancer epidemiology 70 (2020): 101873.
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Daten bereitgestellt von Europe PubMed Central.
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Daten bereitgestellt von Europe PubMed Central.
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