Aescin - a natural soap for the formation of lipid nanodiscs with tunable size

Geisler R, Pedersen MC, Preisig N, Hannappel Y, Prevost S, Dattani R, Arleth L, Hellweg T (2021)
Soft matter.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
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Autor*in
Geisler, Ramsia; Pedersen, Martin Cramer; Preisig, Natalie; Hannappel, Yvonne; Prevost, Sylvain; Dattani, Rajeev; Arleth, Lise; Hellweg, ThomasUniBi
Abstract / Bemerkung
The saponin beta-aescin from the seed extract of the horse chestnut tree Aesculus hippocastanum has demonstrated a beneficial role in clinical therapy which is in part related to its strong interaction with biological membranes. In this context the present work investigates the self-assembly of nm-sized discoidal lipid nanoparticles composed of beta-aescin and the phospholipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC). The discoidal lipid nanoparticles reassemble from small discs into larger discs, ribbons and finally stacks of sheets upon heating from gel-phase to fluid phase DMPC. The morphological transition of the lipid nano-particles is mainly triggered by the phospholipid phase state change. The final morphology depends on the phospholipid-to-saponin ratio and the actual temperature. The study is conducted by small-angle X-ray scattering (SAXS) and transmission (TEM) and freeze fracture electron microscopy (FFEM) are used to cover larger length scales. Two different models, representing a disc and ribbon-like shape are applied to the SAXS data, evaluating possible geometries and molecular mixing of the nano-particles. The stacked sheets are analysed by the Caille theory.
Erscheinungsjahr
2021
Zeitschriftentitel
Soft matter
eISSN
1744-6848
Page URI
https://pub.uni-bielefeld.de/record/2949963

Zitieren

Geisler R, Pedersen MC, Preisig N, et al. Aescin - a natural soap for the formation of lipid nanodiscs with tunable size. Soft matter. 2021.
Geisler, R., Pedersen, M. C., Preisig, N., Hannappel, Y., Prevost, S., Dattani, R., Arleth, L., et al. (2021). Aescin - a natural soap for the formation of lipid nanodiscs with tunable size. Soft matter. https://doi.org/10.1039/d0sm02043e
Geisler, R., Pedersen, M. C., Preisig, N., Hannappel, Y., Prevost, S., Dattani, R., Arleth, L., and Hellweg, T. (2021). Aescin - a natural soap for the formation of lipid nanodiscs with tunable size. Soft matter.
Geisler, R., et al., 2021. Aescin - a natural soap for the formation of lipid nanodiscs with tunable size. Soft matter.
R. Geisler, et al., “Aescin - a natural soap for the formation of lipid nanodiscs with tunable size”, Soft matter, 2021.
Geisler, R., Pedersen, M.C., Preisig, N., Hannappel, Y., Prevost, S., Dattani, R., Arleth, L., Hellweg, T.: Aescin - a natural soap for the formation of lipid nanodiscs with tunable size. Soft matter. (2021).
Geisler, Ramsia, Pedersen, Martin Cramer, Preisig, Natalie, Hannappel, Yvonne, Prevost, Sylvain, Dattani, Rajeev, Arleth, Lise, and Hellweg, Thomas. “Aescin - a natural soap for the formation of lipid nanodiscs with tunable size”. Soft matter (2021).

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