A new cerebroside and bioactive compounds from Celtis adolphi-friderici Engl. (Cannabaceae)

Dongmo Jumeta KJ, Kenou Kagho DU, Terence Ateba JE, Fongang Fotsing YS, Kezetas Bankeu JJ, Sewald N, Ndjakou BL, Mehreen L, Ali MS, Ngouela AS (2021)
Biochemical Systematics and Ecology 94: 104201.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Dongmo Jumeta, Kevine Johane; Kenou Kagho, Donald Ulrich; Terence Ateba, Joel Eddy; Fongang Fotsing, Yannick Stéphane; Kezetas Bankeu, Jean Jules; Sewald, NorbertUniBi ; Ndjakou, Bruno Lenta; Mehreen, Lateef; Ali, Muhammad Shaiq; Ngouela, Augustin Silvère
Abstract / Bemerkung
A phytochemical investigation of the roots of Celtis adolphi-friderici Engl. led to the isolation of a previously undescribed cerebroside named, eloundemnoside (1), alongside with seventeen known compounds (2–18). Their chemical structures were elucidated based on the analysis of their NMR and MS data. All the compounds were isolated from this specie for the first time, while eight known compounds (4–5, 12–13, 15–18) are obtained from the genus Celtis for the first time. The isolates were screened for their antioxidant, lipoxygenase, urease, and butyrylcholinesterase enzyme inhibitory activities. Compounds 4, 7 and 12 showed good antioxidant activities with IC50 values of 22.2, 29.3, and 13.2 μM, respectively. In addition, azelaic acid (12) showed the best lipoxygenase inhibition (IC50 value of 16.3 μM), while friedelin (2) exhibited the highest inhibition of urease with an IC50 value of 15.3 μM. However, all the compounds tested had moderate butyrylcholinesterase inhibitory properties. The chemophenetic relationship of the isolates and their significance were discussed.
Stichworte
Celtis adolphi-Friderici; Cerebroside; Antioxidant; Urease; Lipoxygenase; Butyrylcholinesterase
Erscheinungsjahr
2021
Zeitschriftentitel
Biochemical Systematics and Ecology
Band
94
Art.-Nr.
104201
ISSN
03051978
Page URI
https://pub.uni-bielefeld.de/record/2949876

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Dongmo Jumeta KJ, Kenou Kagho DU, Terence Ateba JE, et al. A new cerebroside and bioactive compounds from Celtis adolphi-friderici Engl. (Cannabaceae). Biochemical Systematics and Ecology. 2021;94: 104201.
Dongmo Jumeta, K. J., Kenou Kagho, D. U., Terence Ateba, J. E., Fongang Fotsing, Y. S., Kezetas Bankeu, J. J., Sewald, N., Ndjakou, B. L., et al. (2021). A new cerebroside and bioactive compounds from Celtis adolphi-friderici Engl. (Cannabaceae). Biochemical Systematics and Ecology, 94, 104201. doi:10.1016/j.bse.2020.104201
Dongmo Jumeta, K. J., Kenou Kagho, D. U., Terence Ateba, J. E., Fongang Fotsing, Y. S., Kezetas Bankeu, J. J., Sewald, N., Ndjakou, B. L., Mehreen, L., Ali, M. S., and Ngouela, A. S. (2021). A new cerebroside and bioactive compounds from Celtis adolphi-friderici Engl. (Cannabaceae). Biochemical Systematics and Ecology 94:104201.
Dongmo Jumeta, K.J., et al., 2021. A new cerebroside and bioactive compounds from Celtis adolphi-friderici Engl. (Cannabaceae). Biochemical Systematics and Ecology, 94: 104201.
K.J. Dongmo Jumeta, et al., “A new cerebroside and bioactive compounds from Celtis adolphi-friderici Engl. (Cannabaceae)”, Biochemical Systematics and Ecology, vol. 94, 2021, : 104201.
Dongmo Jumeta, K.J., Kenou Kagho, D.U., Terence Ateba, J.E., Fongang Fotsing, Y.S., Kezetas Bankeu, J.J., Sewald, N., Ndjakou, B.L., Mehreen, L., Ali, M.S., Ngouela, A.S.: A new cerebroside and bioactive compounds from Celtis adolphi-friderici Engl. (Cannabaceae). Biochemical Systematics and Ecology. 94, : 104201 (2021).
Dongmo Jumeta, Kevine Johane, Kenou Kagho, Donald Ulrich, Terence Ateba, Joel Eddy, Fongang Fotsing, Yannick Stéphane, Kezetas Bankeu, Jean Jules, Sewald, Norbert, Ndjakou, Bruno Lenta, Mehreen, Lateef, Ali, Muhammad Shaiq, and Ngouela, Augustin Silvère. “A new cerebroside and bioactive compounds from Celtis adolphi-friderici Engl. (Cannabaceae)”. Biochemical Systematics and Ecology 94 (2021): 104201.

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