Molecular pathogenesis of cutaneous lymphoma-Future directions

Stadler R, Hain C, Cieslak C, Stranzenbach R (2020)
Experimental Dermatology .

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Stadler, Rudolf; Hain, CarstenUniBi; Cieslak, Cassandra; Stranzenbach, Rene
Abstract / Bemerkung
The pathogenesis of cutaneous T-cell lymphomas is not clear. In recent years, the genetic changes in CTCL were explored. The detected mutations showed a great deal of heterogeneity between individual patients. The studies documented various copy number variations (CNV) and single nucleotide variations (SNV) in multiple genes involved in multiple signalling pathways. Recurrently mutated signalling pathways include JAK-STAT, MAPK, T-cell receptor, TNF receptor and NF kappa B signalling. In the period between 2018 and today, additional studies towards the genetic changes in CTCL were carried out. Genetic changes in gamma delta T-cell lymphoma are also shown in genes of the JAK-STAT, MAPK, MYC and chromatin signalling pathways. These studies might indicate a shift away from targeted sequencing approaches towards whole-genome sequencing. This approach demands additional resources in terms of funding but has the advantage of finding mutations in non-coding regions. These mutations were neglected for a long time, but as shown in contemporary research these regions harbour highly recurrent mutations affecting gene expression and regulation. Nevertheless, the detection of specific molecular changes in known pathways enables considerations for targeted therapies.
Stichworte
cutaneous T‐; cell lymphoma; genetic landscape; targeted therapy
Erscheinungsjahr
2020
Zeitschriftentitel
Experimental Dermatology
ISSN
0906-6705
eISSN
1600-0625
Page URI
https://pub.uni-bielefeld.de/record/2948936

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Stadler R, Hain C, Cieslak C, Stranzenbach R. Molecular pathogenesis of cutaneous lymphoma-Future directions. Experimental Dermatology . 2020.
Stadler, R., Hain, C., Cieslak, C., & Stranzenbach, R. (2020). Molecular pathogenesis of cutaneous lymphoma-Future directions. Experimental Dermatology . doi:10.1111/exd.14211
Stadler, R., Hain, C., Cieslak, C., and Stranzenbach, R. (2020). Molecular pathogenesis of cutaneous lymphoma-Future directions. Experimental Dermatology .
Stadler, R., et al., 2020. Molecular pathogenesis of cutaneous lymphoma-Future directions. Experimental Dermatology .
R. Stadler, et al., “Molecular pathogenesis of cutaneous lymphoma-Future directions”, Experimental Dermatology , 2020.
Stadler, R., Hain, C., Cieslak, C., Stranzenbach, R.: Molecular pathogenesis of cutaneous lymphoma-Future directions. Experimental Dermatology . (2020).
Stadler, Rudolf, Hain, Carsten, Cieslak, Cassandra, and Stranzenbach, Rene. “Molecular pathogenesis of cutaneous lymphoma-Future directions”. Experimental Dermatology (2020).

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