Spatial evaluation of long-term metabolic changes induced by cisplatin nephrotoxicity

Sahin M, Neumann JM, Riefke B, Bednarz H, Gutberlet K, Giampa M, Niehaus K, Fatangare A (2020)
Toxicology letters 334: 36-43.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Cisplatin is a widely used chemotherapeutic agent. However, it is causing nephrotoxic side effects including a reduced glomerular filtration rate and acute kidney injury. Although kidneys can recover to an extent from the treatment, long-term damage is possible. While a lot of research is focusing on short-term effects, little is known about adverse metabolic effects in the process of recovery. In this study, male Han Wistar rats were dosed with a single intraperitoneal injection of 3 mg/kg cisplatin. Urine and kidney samples were harvested 3, 8 and 26 days after administration. Tubular injury was demonstrated through urinary biomarkers. Complementing this, mass spectrometry imaging gives insight on molecular alterations on a spatial level, thus making it well suited to analyze short- and long-term disturbances. Various metabolic pathways seem to be affected, as changes in a wide range of metabolites were observed between treated and control animals. Besides previously reported early changes in kidney metabolism, unprecedented long-term effects were detected including deviation in nucleotides, antioxidants, and phospholipids. Copyright © 2020 Elsevier B.V. All rights reserved.
Erscheinungsjahr
2020
Zeitschriftentitel
Toxicology letters
Band
334
Seite(n)
36-43
eISSN
1879-3169
Page URI
https://pub.uni-bielefeld.de/record/2946331

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Sahin M, Neumann JM, Riefke B, et al. Spatial evaluation of long-term metabolic changes induced by cisplatin nephrotoxicity. Toxicology letters. 2020;334:36-43.
Sahin, M., Neumann, J. M., Riefke, B., Bednarz, H., Gutberlet, K., Giampa, M., Niehaus, K., et al. (2020). Spatial evaluation of long-term metabolic changes induced by cisplatin nephrotoxicity. Toxicology letters, 334, 36-43. https://doi.org/10.1016/j.toxlet.2020.09.006
Sahin, M., Neumann, J. M., Riefke, B., Bednarz, H., Gutberlet, K., Giampa, M., Niehaus, K., and Fatangare, A. (2020). Spatial evaluation of long-term metabolic changes induced by cisplatin nephrotoxicity. Toxicology letters 334, 36-43.
Sahin, M., et al., 2020. Spatial evaluation of long-term metabolic changes induced by cisplatin nephrotoxicity. Toxicology letters, 334, p 36-43.
M. Sahin, et al., “Spatial evaluation of long-term metabolic changes induced by cisplatin nephrotoxicity”, Toxicology letters, vol. 334, 2020, pp. 36-43.
Sahin, M., Neumann, J.M., Riefke, B., Bednarz, H., Gutberlet, K., Giampa, M., Niehaus, K., Fatangare, A.: Spatial evaluation of long-term metabolic changes induced by cisplatin nephrotoxicity. Toxicology letters. 334, 36-43 (2020).
Sahin, Mikail, Neumann, Judith Martha, Riefke, Bjoern, Bednarz, Hanna, Gutberlet, Katrin, Giampa, Marco, Niehaus, Karsten, and Fatangare, Amol. “Spatial evaluation of long-term metabolic changes induced by cisplatin nephrotoxicity”. Toxicology letters 334 (2020): 36-43.

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