Asthma in farm children is more determined by genetic polymorphisms and in non-farm children by environmental factors

Krautenbacher N, Kabesch M, Horak E, Braun-Fahrlander C, Genuneit J, Boznanski A, von Mutius E, Theis F, Fuchs C, Ege MJ (2021)
Pediatric allergy and immunology 32(2): 295-304.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Krautenbacher, Norbert; Kabesch, Michael; Horak, Elisabeth; Braun-Fahrlander, Charlotte; Genuneit, Jon; Boznanski, Andrzej; von Mutius, Erika; Theis, Fabian; Fuchs, ChristianeUniBi ; Ege, Markus J
Abstract / Bemerkung
BACKGROUND: The asthma syndrome is influenced by hereditary and environmental factors. With the example of farm exposure, we study whether genetic and environmental factors interact for asthma.; METHODS: Statistical learning approaches based on penalized regression and decision trees were used to predict asthma in the GABRIELA study with 850 cases (9% farm children) and 857 controls (14% farm children). Single-nucleotide polymorphisms (SNPs) were selected from a genome-wide dataset based on a literature search or by statistical selection techniques. Prediction was assessed by receiver operating characteristics (ROC) curves and validated in the PASTURE cohort.; RESULTS: Prediction by family history of asthma and atopy yielded an area under the ROC curve (AUC) of 0.62 [0.57-0.66] in the random forest machine learning approach. By adding information on demographics (sex and age) and 26 environmental exposure variables, the quality of prediction significantly improved (AUC=0.65 [0.61-0.70]). In farm children, however, environmental variables did not improve prediction quality. Rather SNPs related to IL33 and RAD50 contributed significantly to the prediction of asthma (AUC=0.70 [0.62-0.78]).; CONCLUSIONS: Asthma in farm children is more likely predicted by other factors as compared to non-farm children though in both forms, family history may integrate environmental exposure, genotype, and degree of penetrance. This article is protected by copyright. All rights reserved.
Erscheinungsjahr
2021
Zeitschriftentitel
Pediatric allergy and immunology
Band
32
Ausgabe
2
Seite(n)
295-304
eISSN
1399-3038
Page URI
https://pub.uni-bielefeld.de/record/2946318

Zitieren

Krautenbacher N, Kabesch M, Horak E, et al. Asthma in farm children is more determined by genetic polymorphisms and in non-farm children by environmental factors. Pediatric allergy and immunology . 2021;32(2):295-304.
Krautenbacher, N., Kabesch, M., Horak, E., Braun-Fahrlander, C., Genuneit, J., Boznanski, A., von Mutius, E., et al. (2021). Asthma in farm children is more determined by genetic polymorphisms and in non-farm children by environmental factors. Pediatric allergy and immunology , 32(2), 295-304. https://doi.org/10.1111/pai.13385
Krautenbacher, N., Kabesch, M., Horak, E., Braun-Fahrlander, C., Genuneit, J., Boznanski, A., von Mutius, E., Theis, F., Fuchs, C., and Ege, M. J. (2021). Asthma in farm children is more determined by genetic polymorphisms and in non-farm children by environmental factors. Pediatric allergy and immunology 32, 295-304.
Krautenbacher, N., et al., 2021. Asthma in farm children is more determined by genetic polymorphisms and in non-farm children by environmental factors. Pediatric allergy and immunology , 32(2), p 295-304.
N. Krautenbacher, et al., “Asthma in farm children is more determined by genetic polymorphisms and in non-farm children by environmental factors”, Pediatric allergy and immunology , vol. 32, 2021, pp. 295-304.
Krautenbacher, N., Kabesch, M., Horak, E., Braun-Fahrlander, C., Genuneit, J., Boznanski, A., von Mutius, E., Theis, F., Fuchs, C., Ege, M.J.: Asthma in farm children is more determined by genetic polymorphisms and in non-farm children by environmental factors. Pediatric allergy and immunology . 32, 295-304 (2021).
Krautenbacher, Norbert, Kabesch, Michael, Horak, Elisabeth, Braun-Fahrlander, Charlotte, Genuneit, Jon, Boznanski, Andrzej, von Mutius, Erika, Theis, Fabian, Fuchs, Christiane, and Ege, Markus J. “Asthma in farm children is more determined by genetic polymorphisms and in non-farm children by environmental factors”. Pediatric allergy and immunology 32.2 (2021): 295-304.

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