NTRK2 methylation is related to reduced PTSD risk in two African cohorts of trauma survivors

Vukojevic V, Coynel D, Ghaffari NR, Freytag V, Elbert T, Kolassa I-T, Wilker S, McGaugh JL, Papassotiropoulos A, de Quervain DJ-F (2020)
Proceedings of the National Academy of Sciences of the United States of America 117(35): 21667-21672.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Vukojevic, Vanja; Coynel, David; Ghaffari, Navid R; Freytag, Virginie; Elbert, Thomas; Kolassa, Iris-Tatjana; Wilker, SarahUniBi; McGaugh, James L; Papassotiropoulos, Andreas; de Quervain, Dominique J-F
Abstract / Bemerkung
Extensive pharmacologic, genetic, and epigenetic research has linked the glucocorticoid receptor (GR) to memory processes, and to risk and symptoms of posttraumatic stress disorder (PTSD). In the present study we investigated the epigenetic pattern of 12 genes involved in the regulation of GR signaling in two African populations of heavily traumatized individuals: Survivors of the rebel war in northern Uganda (n = 463) and survivors of the Rwandan genocide (n = 350). The strongest link between regional methylation and PTSD risk and symptoms was observed for NTRK2, which encodes the transmembrane receptor tropomyosin-related kinase B, binds the brain-derived neurotrophic factor, and has been shown to play an important role in memory formation. NTRK2 methylation was not related to trauma load, suggesting that methylation differences preexisted the trauma. Because NTRK2 methylation differences were predominantly associated with memory-related PTSD symptoms, and because they seem to precede traumatic events, we next investigated the relationship between NTRK2 methylation and memory in a sample of nontraumatized individuals (n = 568). We found that NTRK2 methylation was negatively associated with recognition memory performance. Furthermore, fMRI analyses revealed NTRK2 methylation-dependent differences in brain network activity related to recognition memory. The present study demonstrates that NTRK2 is epigenetically linked to memory functions in nontraumatized subjects and to PTSD risk and symptoms in traumatized populations.
Erscheinungsjahr
2020
Zeitschriftentitel
Proceedings of the National Academy of Sciences of the United States of America
Band
117
Ausgabe
35
Seite(n)
21667-21672
eISSN
1091-6490
Page URI
https://pub.uni-bielefeld.de/record/2945779

Zitieren

Vukojevic V, Coynel D, Ghaffari NR, et al. NTRK2 methylation is related to reduced PTSD risk in two African cohorts of trauma survivors. Proceedings of the National Academy of Sciences of the United States of America. 2020;117(35):21667-21672.
Vukojevic, V., Coynel, D., Ghaffari, N. R., Freytag, V., Elbert, T., Kolassa, I. - T., Wilker, S., et al. (2020). NTRK2 methylation is related to reduced PTSD risk in two African cohorts of trauma survivors. Proceedings of the National Academy of Sciences of the United States of America, 117(35), 21667-21672. doi:10.1073/pnas.2008415117
Vukojevic, V., Coynel, D., Ghaffari, N. R., Freytag, V., Elbert, T., Kolassa, I. - T., Wilker, S., McGaugh, J. L., Papassotiropoulos, A., and de Quervain, D. J. - F. (2020). NTRK2 methylation is related to reduced PTSD risk in two African cohorts of trauma survivors. Proceedings of the National Academy of Sciences of the United States of America 117, 21667-21672.
Vukojevic, V., et al., 2020. NTRK2 methylation is related to reduced PTSD risk in two African cohorts of trauma survivors. Proceedings of the National Academy of Sciences of the United States of America, 117(35), p 21667-21672.
V. Vukojevic, et al., “NTRK2 methylation is related to reduced PTSD risk in two African cohorts of trauma survivors”, Proceedings of the National Academy of Sciences of the United States of America, vol. 117, 2020, pp. 21667-21672.
Vukojevic, V., Coynel, D., Ghaffari, N.R., Freytag, V., Elbert, T., Kolassa, I.-T., Wilker, S., McGaugh, J.L., Papassotiropoulos, A., de Quervain, D.J.-F.: NTRK2 methylation is related to reduced PTSD risk in two African cohorts of trauma survivors. Proceedings of the National Academy of Sciences of the United States of America. 117, 21667-21672 (2020).
Vukojevic, Vanja, Coynel, David, Ghaffari, Navid R, Freytag, Virginie, Elbert, Thomas, Kolassa, Iris-Tatjana, Wilker, Sarah, McGaugh, James L, Papassotiropoulos, Andreas, and de Quervain, Dominique J-F. “NTRK2 methylation is related to reduced PTSD risk in two African cohorts of trauma survivors”. Proceedings of the National Academy of Sciences of the United States of America 117.35 (2020): 21667-21672.

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