Central Metabolism in Mammals and Plants As a Hub for Controlling Cell Fate

Selinski J, Scheibe R (2020)
Antioxidants & Redox Signaling.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
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Autor*in
Selinski, JenniferUniBi; Scheibe, Renate
Abstract / Bemerkung
Significance:The importance of oxidoreductases in energy metabolism together with the occurrence of enzymes of central metabolism in the nucleus gave rise to the active research field aiming to understand moonlighting enzymes that undergo post-translational modifications (PTMs) before carrying out new tasks. Recent Advances:Cytosolic enzymes were shown to induce gene transcription after PTM and concomitant translocation to the nucleus. Changed properties of the oxidized forms of cytosolic glyceraldehyde 3-phosphate dehydrogenase, and also malate dehydrogenases and others, are the basis for a hypothesis suggesting moonlighting functions that directly link energy metabolism to adaptive responses required for maintenance of redox-homeostasis in all eukaryotes. Critical Issues:Small molecules, such as metabolic intermediates, coenzymes, or reduced glutathione, were shown to fine-tune the redox switches, interlinking redox state, metabolism, and induction of new functionsvianuclear gene expression. The cytosol with its metabolic enzymes connecting energy fluxes between the various cell compartments can be seen as a hub for redox signaling, integrating the different signals for graded and directed responses in stressful situations. Future Directions:Enzymes of central metabolism were shown to interact with p53 or the assumed plant homologue suppressor of gamma response 1 (SOG1), an NAM, ATAF, and CUC transcription factor involved in the stress response upon ultraviolet exposure. Metabolic enzymes serve as sensors for imbalances, their inhibition leading to changed energy metabolism, and the adoption of transcriptional coactivator activities. Depending on the intensity of the impact, rerouting of energy metabolism, proliferation, DNA repair, cell cycle arrest, immune responses, or cell death will be induced.Antioxid. Redox Signal.00, 000-000
Stichworte
GAPDH; moonlighting; thiol switches; redox sensing; redox signaling; energy metabolism
Erscheinungsjahr
2020
Zeitschriftentitel
Antioxidants & Redox Signaling
ISSN
1523-0864
eISSN
1557-7716
Page URI
https://pub.uni-bielefeld.de/record/2945611

Zitieren

Selinski J, Scheibe R. Central Metabolism in Mammals and Plants As a Hub for Controlling Cell Fate. Antioxidants & Redox Signaling. 2020.
Selinski, J., & Scheibe, R. (2020). Central Metabolism in Mammals and Plants As a Hub for Controlling Cell Fate. Antioxidants & Redox Signaling. doi:10.1089/ars.2020.8121
Selinski, J., and Scheibe, R. (2020). Central Metabolism in Mammals and Plants As a Hub for Controlling Cell Fate. Antioxidants & Redox Signaling.
Selinski, J., & Scheibe, R., 2020. Central Metabolism in Mammals and Plants As a Hub for Controlling Cell Fate. Antioxidants & Redox Signaling.
J. Selinski and R. Scheibe, “Central Metabolism in Mammals and Plants As a Hub for Controlling Cell Fate”, Antioxidants & Redox Signaling, 2020.
Selinski, J., Scheibe, R.: Central Metabolism in Mammals and Plants As a Hub for Controlling Cell Fate. Antioxidants & Redox Signaling. (2020).
Selinski, Jennifer, and Scheibe, Renate. “Central Metabolism in Mammals and Plants As a Hub for Controlling Cell Fate”. Antioxidants & Redox Signaling (2020).

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