Altered relaxation times in MRI indicate bronchopulmonary dysplasia

Förster K, Ertl-Wagner B, Ehrhardt H, Busen H, Sass S, Pomschar A, Naehrlich L, Schulze A, Flemmer AW, Hübener C, Eickelberg O, et al. (2019)
Thorax 75(2): 184-187.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Förster, Kai; Ertl-Wagner, Birgit; Ehrhardt, Harald; Busen, HannahUniBi ; Sass, Steffen; Pomschar, Andreas; Naehrlich, Lutz; Schulze, Andreas; Flemmer, Andreas W; Hübener, Christoph; Eickelberg, Oliver; Theis, Fabian
Alle
Abstract / Bemerkung
We developed a MRI protocol using transverse (T2) and longitudinal (T1) mapping sequences to characterise lung structural changes in preterm infants with bronchopulmonary dysplasia (BPD). We prospectively enrolled 61 infants to perform 3-Tesla MRI of the lung in quiet sleep. Statistical analysis was performed using logistic Group Lasso regression and logistic regression. Increased lung T2 relaxation time and decreased lung T1 relaxation time indicated BPD yielding an area under the curve (AUC) of 0.80. Results were confirmed in an independent study cohort (AUC 0.75) and mirrored by lung function testing, indicating the high potential for MRI in future BPD diagnostics.Trial registrationDRKS00004600.
Stichworte
Pulmonary and Respiratory Medicine
Erscheinungsjahr
2019
Zeitschriftentitel
Thorax
Band
75
Ausgabe
2
Seite(n)
184-187
ISSN
0040-6376
eISSN
1468-3296
Page URI
https://pub.uni-bielefeld.de/record/2945535

Zitieren

Förster K, Ertl-Wagner B, Ehrhardt H, et al. Altered relaxation times in MRI indicate bronchopulmonary dysplasia. Thorax. 2019;75(2):184-187.
Förster, K., Ertl-Wagner, B., Ehrhardt, H., Busen, H., Sass, S., Pomschar, A., Naehrlich, L., et al. (2019). Altered relaxation times in MRI indicate bronchopulmonary dysplasia. Thorax, 75(2), 184-187. doi:10.1136/thoraxjnl-2018-212384
Förster, K., Ertl-Wagner, B., Ehrhardt, H., Busen, H., Sass, S., Pomschar, A., Naehrlich, L., Schulze, A., Flemmer, A. W., Hübener, C., et al. (2019). Altered relaxation times in MRI indicate bronchopulmonary dysplasia. Thorax 75, 184-187.
Förster, K., et al., 2019. Altered relaxation times in MRI indicate bronchopulmonary dysplasia. Thorax, 75(2), p 184-187.
K. Förster, et al., “Altered relaxation times in MRI indicate bronchopulmonary dysplasia”, Thorax, vol. 75, 2019, pp. 184-187.
Förster, K., Ertl-Wagner, B., Ehrhardt, H., Busen, H., Sass, S., Pomschar, A., Naehrlich, L., Schulze, A., Flemmer, A.W., Hübener, C., Eickelberg, O., Theis, F., Dietrich, O., Hilgendorff, A.: Altered relaxation times in MRI indicate bronchopulmonary dysplasia. Thorax. 75, 184-187 (2019).
Förster, Kai, Ertl-Wagner, Birgit, Ehrhardt, Harald, Busen, Hannah, Sass, Steffen, Pomschar, Andreas, Naehrlich, Lutz, Schulze, Andreas, Flemmer, Andreas W, Hübener, Christoph, Eickelberg, Oliver, Theis, Fabian, Dietrich, Olaf, and Hilgendorff, Anne. “Altered relaxation times in MRI indicate bronchopulmonary dysplasia”. Thorax 75.2 (2019): 184-187.

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