Altered relaxation times in MRI indicate bronchopulmonary dysplasia

Förster, Kai; Ertl-Wagner, Birgit; Ehrhardt, Harald; Busen, Hannah; Sass, Steffen; Pomschar, Andreas; Naehrlich, Lutz; Schulze, Andreas; Flemmer, Andreas W.; Hübener, Christoph; Eickelberg, Oliver; Theis, Fabian; Dietrich, Olaf; Hilgendorff, Anne

Altered relaxation times in MRI indicate bronchopulmonary dysplasia

Förster K, Ertl-Wagner B, Ehrhardt H, Busen H, Sass S, Pomschar A, Naehrlich L, Schulze A, Flemmer AW, Hübener C, Eickelberg O, et al. (2019)
Thorax 75(2): 184-187.

Zeitschriftenaufsatz | Veröffentlicht | Englisch

Download

Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!

DOI

https://doi.org/10.1136/thoraxjnl-2018-212384

Autor*in

Förster, Kai; Ertl-Wagner, Birgit; Ehrhardt, Harald; Busen, Hannah^UniBi ; Sass, Steffen; Pomschar, Andreas; Naehrlich, Lutz; Schulze, Andreas; Flemmer, Andreas W.; Hübener, Christoph; Eickelberg, Oliver; Theis, Fabian
Alle

Einrichtung

Fakultät für Wirtschaftswissenschaften > Lehrstuhl für Data Science

Abstract / Bemerkung

We developed a MRI protocol using transverse (T2) and longitudinal (T1) mapping sequences to characterise lung structural changes in preterm infants with bronchopulmonary dysplasia (BPD). We prospectively enrolled 61 infants to perform 3-Tesla MRI of the lung in quiet sleep. Statistical analysis was performed using logistic Group Lasso regression and logistic regression. Increased lung T2 relaxation time and decreased lung T1 relaxation time indicated BPD yielding an area under the curve (AUC) of 0.80. Results were confirmed in an independent study cohort (AUC 0.75) and mirrored by lung function testing, indicating the high potential for MRI in future BPD diagnostics.Trial registrationDRKS00004600.

Stichworte

Pulmonary and Respiratory Medicine

Erscheinungsjahr

2019

Zeitschriftentitel

Thorax

Band

Ausgabe

Seite(n)

184-187

ISSN

0040-6376

eISSN

1468-3296

Page URI

https://pub.uni-bielefeld.de/record/2945535

Zitieren

Förster K, Ertl-Wagner B, Ehrhardt H, et al. Altered relaxation times in MRI indicate bronchopulmonary dysplasia. Thorax. 2019;75(2):184-187.

Förster, K., Ertl-Wagner, B., Ehrhardt, H., Busen, H., Sass, S., Pomschar, A., Naehrlich, L., et al. (2019). Altered relaxation times in MRI indicate bronchopulmonary dysplasia. Thorax, 75(2), 184-187. https://doi.org/10.1136/thoraxjnl-2018-212384

Förster, Kai, Ertl-Wagner, Birgit, Ehrhardt, Harald, Busen, Hannah, Sass, Steffen, Pomschar, Andreas, Naehrlich, Lutz, et al. 2019. “Altered relaxation times in MRI indicate bronchopulmonary dysplasia”. Thorax 75 (2): 184-187.

Förster, K., Ertl-Wagner, B., Ehrhardt, H., Busen, H., Sass, S., Pomschar, A., Naehrlich, L., Schulze, A., Flemmer, A. W., Hübener, C., et al. (2019). Altered relaxation times in MRI indicate bronchopulmonary dysplasia. Thorax 75, 184-187.

Förster, K., et al., 2019. Altered relaxation times in MRI indicate bronchopulmonary dysplasia. Thorax, 75(2), p 184-187.

K. Förster, et al., “Altered relaxation times in MRI indicate bronchopulmonary dysplasia”, Thorax, vol. 75, 2019, pp. 184-187.

Förster, K., Ertl-Wagner, B., Ehrhardt, H., Busen, H., Sass, S., Pomschar, A., Naehrlich, L., Schulze, A., Flemmer, A.W., Hübener, C., Eickelberg, O., Theis, F., Dietrich, O., Hilgendorff, A.: Altered relaxation times in MRI indicate bronchopulmonary dysplasia. Thorax. 75, 184-187 (2019).

Förster, Kai, Ertl-Wagner, Birgit, Ehrhardt, Harald, Busen, Hannah, Sass, Steffen, Pomschar, Andreas, Naehrlich, Lutz, Schulze, Andreas, Flemmer, Andreas W., Hübener, Christoph, Eickelberg, Oliver, Theis, Fabian, Dietrich, Olaf, and Hilgendorff, Anne. “Altered relaxation times in MRI indicate bronchopulmonary dysplasia”. Thorax 75.2 (2019): 184-187.

Daten bereitgestellt von European Bioinformatics Institute (EBI)