Antiproliferative activity of a new xanthone derivative from leaves of Garcinia nobilis Engl.

Fouotsa H, Dzoyem JP, Lannang AM, Stammler H-G, Mbazoa CD, Luhmer M, Nkengfack AE, Allemann E, Delie F, Meyer F, Sewald N (2020)
Natural product research.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
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Autor*in
Fouotsa, HuguesUniBi; Dzoyem, Jean Paul; Lannang, Alain Meli; Stammler, Hans-GeorgUniBi; Mbazoa, Celine Djama; Luhmer, Michel; Nkengfack, Augustin Ephrem; Allemann, Eric; Delie, Florence; Meyer, Franck; Sewald, NorbertUniBi
Abstract / Bemerkung
A new xanthone, mboudiexanthone (1), together with five known compounds, euxanthone (2), isogarcinol (3), garcinol (4), betulinic acid (5) and zeorin (6) were isolated from the leaves of Garcinia nobilis Engl. The structures were determined by 1D and 2D NMR techniques and X-ray diffraction for 6. The invitro antiproliferative properties of isolated compounds were evaluated against the human breast cancer cell line MCF-7. All compounds showed an antiproliferative activity with an IC50 value down to 11M for isogarcinol.
Erscheinungsjahr
2020
Zeitschriftentitel
Natural product research
eISSN
1478-6427
Page URI
https://pub.uni-bielefeld.de/record/2945525

Zitieren

Fouotsa H, Dzoyem JP, Lannang AM, et al. Antiproliferative activity of a new xanthone derivative from leaves of Garcinia nobilis Engl. Natural product research. 2020.
Fouotsa, H., Dzoyem, J. P., Lannang, A. M., Stammler, H. - G., Mbazoa, C. D., Luhmer, M., Nkengfack, A. E., et al. (2020). Antiproliferative activity of a new xanthone derivative from leaves of Garcinia nobilis Engl. Natural product research. doi:10.1080/14786419.2020.1806270
Fouotsa, H., Dzoyem, J. P., Lannang, A. M., Stammler, H. - G., Mbazoa, C. D., Luhmer, M., Nkengfack, A. E., Allemann, E., Delie, F., Meyer, F., et al. (2020). Antiproliferative activity of a new xanthone derivative from leaves of Garcinia nobilis Engl. Natural product research.
Fouotsa, H., et al., 2020. Antiproliferative activity of a new xanthone derivative from leaves of Garcinia nobilis Engl. Natural product research.
H. Fouotsa, et al., “Antiproliferative activity of a new xanthone derivative from leaves of Garcinia nobilis Engl.”, Natural product research, 2020.
Fouotsa, H., Dzoyem, J.P., Lannang, A.M., Stammler, H.-G., Mbazoa, C.D., Luhmer, M., Nkengfack, A.E., Allemann, E., Delie, F., Meyer, F., Sewald, N.: Antiproliferative activity of a new xanthone derivative from leaves of Garcinia nobilis Engl. Natural product research. (2020).
Fouotsa, Hugues, Dzoyem, Jean Paul, Lannang, Alain Meli, Stammler, Hans-Georg, Mbazoa, Celine Djama, Luhmer, Michel, Nkengfack, Augustin Ephrem, Allemann, Eric, Delie, Florence, Meyer, Franck, and Sewald, Norbert. “Antiproliferative activity of a new xanthone derivative from leaves of Garcinia nobilis Engl.”. Natural product research (2020).

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