Recent Advances in Synthetic Application and Engineering of Halogenases

Minges H, Sewald N (2020)
ChemCatChem 12(18): 4450-4470.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Halogenating enzymes are able to introduce halogen substituents under ambient conditions using non-hazardous reagents with intriguing selectivity, which is highly desired in green chemistry. Although C-H functionalization such as halogenation is a well-known transformation in synthetic chemistry, the selective incorporation of halogens using conventional chemical approaches often remains challenging. Therefore, enzyme-based strategies have been emerging as valuable alternatives in recent years. Inspired by manifold developments of enzymatic halogenation, this review focuses on advances of halogenating enzymes and their application with particular emphasis on FAD-dependent halogenases (FDHs). Catalytic strategies, application scope and engineering of FDHs are outlined pointing to the increasing utility of halogenases as promising biocatalysts. Current limitations as well as potential future developments of their synthetic utility are being discussed.
Stichworte
biocatalysis; C-H functionalization; directed evolution; halogenase; protein engineering
Erscheinungsjahr
2020
Zeitschriftentitel
ChemCatChem
Band
12
Ausgabe
18
Seite(n)
4450-4470
ISSN
1867-3880
eISSN
1867-3899
Finanzierungs-Informationen
Open-Access-Publikationskosten wurden durch die Universität Bielefeld im Rahmen des DEAL-Vertrags gefördert.
Page URI
https://pub.uni-bielefeld.de/record/2945445

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Minges H, Sewald N. Recent Advances in Synthetic Application and Engineering of Halogenases. ChemCatChem. 2020;12(18):4450-4470.
Minges, H., & Sewald, N. (2020). Recent Advances in Synthetic Application and Engineering of Halogenases. ChemCatChem, 12(18), 4450-4470. doi:10.1002/cctc.202000531
Minges, H., and Sewald, N. (2020). Recent Advances in Synthetic Application and Engineering of Halogenases. ChemCatChem 12, 4450-4470.
Minges, H., & Sewald, N., 2020. Recent Advances in Synthetic Application and Engineering of Halogenases. ChemCatChem, 12(18), p 4450-4470.
H. Minges and N. Sewald, “Recent Advances in Synthetic Application and Engineering of Halogenases”, ChemCatChem, vol. 12, 2020, pp. 4450-4470.
Minges, H., Sewald, N.: Recent Advances in Synthetic Application and Engineering of Halogenases. ChemCatChem. 12, 4450-4470 (2020).
Minges, Hannah, and Sewald, Norbert. “Recent Advances in Synthetic Application and Engineering of Halogenases”. ChemCatChem 12.18 (2020): 4450-4470.
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2020-10-08T10:54:37Z
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