The chemistry of the West and Central African Penianthus zenkeri Diels (Menispermaceae)

Tabekoueng GB, Akak CM, Happi Mouthe G, Langat MK, Frese M, Stammler H-G, Neumann B, Azebaze AGB, Waffo AFK, Wansi JD, Lenta BN, et al. (2020)
Phytochemistry Letters 38: 12-18.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
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Autor*in
Tabekoueng, Georges Bellier; Akak, Carine Mvot; Happi Mouthe, GervaisUniBi; Langat, Moses K.; Frese, MarcelUniBi; Stammler, Hans-GeorgUniBi; Neumann, BeateUniBi; Azebaze, Anatole Guy Blaise; Waffo, Alain Francois Kamdem; Wansi, Jean Duplex; Lenta, Bruno N.; Sewald, NorbertUniBi
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Abstract / Bemerkung
A phytochemical investigation of the roots and twigs of Penianthus zenkeri Diels led to the identification of twenty four compounds including one previously undescribed C-28 ecdysteroid (1 ) and previously described phytosteroids (2-5, 20, 22, 23 ), phenolic compounds (6-8, 12 ), diterpenoids (9-11 ), alkaloids (13,14, 18, 19 ), a dipeptide (15 ), ursane type triterpenoids (16-17 ), a carbohydrate (21 ) and a fatty alcohol (24 ). Three semi - synthetic derivatives (5b , 5a, 17a ) obtained from acetylation and acetonidation of rubrosterone (5 ), and ally- lation of ursolic acid (17 ), respectively, are also reported. The chemical structures of the compounds were determined using 1D and 2D NMR spectral data, mass spectrometry and by comparison with the data reported in the literature. The absolute configuration of compound 9 was established using X -Ray and ECD analysis. Different extracts of the twigs and roots, compounds 2 - 4 , 6 - 11 , 15 , and 17 - 21 were evaluated for their anti- bacterial, and cytotoxic activities. The twigs extract showed an antibacterial activity with an MIC of 62.5 mu g/mol against Staphylococcus aureus ATCC 4300, while ursolic acid exhibited a moderate cytotoxicity with an IC50 of 50.9 mu M. The chemotaxonomic relevance of the isolated compounds is discussed.
Stichworte
Penianthuszenkeri; C-28 ecdysteroid; Zenkersterone; Rubrosterone; Diterpenoids
Erscheinungsjahr
2020
Zeitschriftentitel
Phytochemistry Letters
Band
38
Seite(n)
12-18
ISSN
1874-3900
eISSN
1876-7486
Page URI
https://pub.uni-bielefeld.de/record/2945441

Zitieren

Tabekoueng GB, Akak CM, Happi Mouthe G, et al. The chemistry of the West and Central African Penianthus zenkeri Diels (Menispermaceae). Phytochemistry Letters. 2020;38:12-18.
Tabekoueng, G. B., Akak, C. M., Happi Mouthe, G., Langat, M. K., Frese, M., Stammler, H. - G., Neumann, B., et al. (2020). The chemistry of the West and Central African Penianthus zenkeri Diels (Menispermaceae). Phytochemistry Letters, 38, 12-18. doi:10.1016/j.phytol.2020.04.017
Tabekoueng, G. B., Akak, C. M., Happi Mouthe, G., Langat, M. K., Frese, M., Stammler, H. - G., Neumann, B., Azebaze, A. G. B., Waffo, A. F. K., Wansi, J. D., et al. (2020). The chemistry of the West and Central African Penianthus zenkeri Diels (Menispermaceae). Phytochemistry Letters 38, 12-18.
Tabekoueng, G.B., et al., 2020. The chemistry of the West and Central African Penianthus zenkeri Diels (Menispermaceae). Phytochemistry Letters, 38, p 12-18.
G.B. Tabekoueng, et al., “The chemistry of the West and Central African Penianthus zenkeri Diels (Menispermaceae)”, Phytochemistry Letters, vol. 38, 2020, pp. 12-18.
Tabekoueng, G.B., Akak, C.M., Happi Mouthe, G., Langat, M.K., Frese, M., Stammler, H.-G., Neumann, B., Azebaze, A.G.B., Waffo, A.F.K., Wansi, J.D., Lenta, B.N., Sewald, N., Vardamides, J.C., Nkengfack, A.E.: The chemistry of the West and Central African Penianthus zenkeri Diels (Menispermaceae). Phytochemistry Letters. 38, 12-18 (2020).
Tabekoueng, Georges Bellier, Akak, Carine Mvot, Happi Mouthe, Gervais, Langat, Moses K., Frese, Marcel, Stammler, Hans-Georg, Neumann, Beate, Azebaze, Anatole Guy Blaise, Waffo, Alain Francois Kamdem, Wansi, Jean Duplex, Lenta, Bruno N., Sewald, Norbert, Vardamides, Juliette Catherine, and Nkengfack, Augustin E. “The chemistry of the West and Central African Penianthus zenkeri Diels (Menispermaceae)”. Phytochemistry Letters 38 (2020): 12-18.

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