Bioguided chemical study of Boswellia dalzielii Hutch. (Burseraceae) for antibacterial agents and a new glucopyranoxylmethoxybenzyle.

Tegasne C, Kapche GDWF, Mawabo IK, Talla RM, Jouda J-B, Happi Mouthe G, Lenta BN, Frese M, Abegaz BM, Sewald N (2020)
Natural product research.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
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Autor*in
Tegasne, Catherine; Kapche, Gilbert Deccaux Wabo Fotso; Mawabo, Isabelle Kamga; Talla, Rostan Mangoua; Jouda, Jean-Bosco; Happi Mouthe, GervaisUniBi; Lenta, Bruno Ndjakou; Frese, MarcelUniBi; Abegaz, Berhanu Molah; Sewald, NorbertUniBi
Abstract / Bemerkung
Stem barks of Boswellia dalzielii are used traditionally for the treatment of various bacterial infections. A bioassay guided fractionation of the MeOH-CH2Cl2 (1/1, v/v) stem barks extract led to the isolation of fourteen compounds 1-14, identified based on spectroscopic data. Dalzienoside (1) is reported here for the first time. The broth microdilution method was used to evaluate the antibacterial activity of the crude extract, fractions and compounds against six bacterial strains. The crude extract exhibited moderate antibacterial activity with MIC of 250muL/ml; two fractions showed significant activities with MICs ranging from 7.8 to 125mug/ml, while alpha-boswellic acid (2), beta-boswellic acid (3), acetyl-11-keto-beta-boswellic acid (4) from these fractions exhibited strong activities with MIC value of 3.125g/mL against Staphylococcus aureus, Salmonella typhi, Enterobacter cloacae, Streptococcus pneumonia and Pseudomonia aeruginosa. This study gives insight into the antibacterial constituents of the stem bark of B. dalzielii and justifies its use in ethnomedicine.
Erscheinungsjahr
2020
Zeitschriftentitel
Natural product research
eISSN
1478-6427
Page URI
https://pub.uni-bielefeld.de/record/2945211

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Tegasne C, Kapche GDWF, Mawabo IK, et al. Bioguided chemical study of Boswellia dalzielii Hutch. (Burseraceae) for antibacterial agents and a new glucopyranoxylmethoxybenzyle. Natural product research. 2020.
Tegasne, C., Kapche, G. D. W. F., Mawabo, I. K., Talla, R. M., Jouda, J. - B., Happi Mouthe, G., Lenta, B. N., et al. (2020). Bioguided chemical study of Boswellia dalzielii Hutch. (Burseraceae) for antibacterial agents and a new glucopyranoxylmethoxybenzyle. Natural product research. doi:10.1080/14786419.2020.1794863
Tegasne, C., Kapche, G. D. W. F., Mawabo, I. K., Talla, R. M., Jouda, J. - B., Happi Mouthe, G., Lenta, B. N., Frese, M., Abegaz, B. M., and Sewald, N. (2020). Bioguided chemical study of Boswellia dalzielii Hutch. (Burseraceae) for antibacterial agents and a new glucopyranoxylmethoxybenzyle. Natural product research.
Tegasne, C., et al., 2020. Bioguided chemical study of Boswellia dalzielii Hutch. (Burseraceae) for antibacterial agents and a new glucopyranoxylmethoxybenzyle. Natural product research.
C. Tegasne, et al., “Bioguided chemical study of Boswellia dalzielii Hutch. (Burseraceae) for antibacterial agents and a new glucopyranoxylmethoxybenzyle.”, Natural product research, 2020.
Tegasne, C., Kapche, G.D.W.F., Mawabo, I.K., Talla, R.M., Jouda, J.-B., Happi Mouthe, G., Lenta, B.N., Frese, M., Abegaz, B.M., Sewald, N.: Bioguided chemical study of Boswellia dalzielii Hutch. (Burseraceae) for antibacterial agents and a new glucopyranoxylmethoxybenzyle. Natural product research. (2020).
Tegasne, Catherine, Kapche, Gilbert Deccaux Wabo Fotso, Mawabo, Isabelle Kamga, Talla, Rostan Mangoua, Jouda, Jean-Bosco, Happi Mouthe, Gervais, Lenta, Bruno Ndjakou, Frese, Marcel, Abegaz, Berhanu Molah, and Sewald, Norbert. “Bioguided chemical study of Boswellia dalzielii Hutch. (Burseraceae) for antibacterial agents and a new glucopyranoxylmethoxybenzyle.”. Natural product research (2020).

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