Glioblastoma multiforme: Metabolic differences to peritumoral tissue and IDH-mutated gliomas revealed by mass spectrometry imaging.

Kampa JM, Kellner U, Marsching C, Ramallo Guevara C, Knappe UJ, Sahin M, Giampa M, Niehaus K, Bednarz H (2020)
Neuropathology : official journal of the Japanese Society of Neuropathology 40(6): 546-558.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Kampa, Judith MarthaUniBi; Kellner, Udo; Marsching, Christian; Ramallo Guevara, Carina; Knappe, Ulrich J; Sahin, MikailUniBi; Giampa, MarcoUniBi; Niehaus, KarstenUniBi; Bednarz, HannaUniBi
Abstract / Bemerkung
Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor. High infiltration rates and poor therapy responses make it the deadliest glioma. The tumor metabolism is known to differ from normal one and is influenced through various factors which can lead to longer survival. Metabolites are small molecules (<1500Da) that display the metabolic pathways in the tissue. To determine the metabolic alterations between tumor and peritumoral tissue in human GBMs, mass spectrometry imaging (MSI) was performed on thin sections from 25 resected tumors. In addition, the GBMs were compared with six gliomas harboring a mutation in the isocitrate dehydrogenase (IDH1) gene (IDH1). With this technique, a manifold of analytes can be easily visualized on a single tissue section. Metabolites were annotated based on their accurate mass using high resolution MSI. Differences in their mean intensities in the tumor and peritumoral areas were statistically evaluated and abundances were visualized on the tissue. Enhanced levels of the antioxidants ascorbic acid, taurine, and glutathione in tumor areas suggest protective effects on the tumor. Increased levels of purine and pyrimidine metabolism compounds in GBM areas indicate the high energy demand. In accordance with these results, enhanced abundances of lactate and glutamine were detected. Moreover, decreased abundance of N-acetylaspartate, a marker for neuronal health, was measured in tumor areas. Obtained metabolic information could potentially support and personalize therapeutic approaches, hence emphasizing the suitability of MSI for GBM research. © 2020 The Authors. Neuropathology published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Neuropathology.
Erscheinungsjahr
2020
Zeitschriftentitel
Neuropathology : official journal of the Japanese Society of Neuropathology
Band
40
Ausgabe
6
Seite(n)
546-558
eISSN
1440-1789
Finanzierungs-Informationen
Open-Access-Publikationskosten wurden durch die Universität Bielefeld im Rahmen des DEAL-Vertrags gefördert.
Page URI
https://pub.uni-bielefeld.de/record/2944994

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Kampa JM, Kellner U, Marsching C, et al. Glioblastoma multiforme: Metabolic differences to peritumoral tissue and IDH-mutated gliomas revealed by mass spectrometry imaging. Neuropathology : official journal of the Japanese Society of Neuropathology. 2020;40(6):546-558.
Kampa, J. M., Kellner, U., Marsching, C., Ramallo Guevara, C., Knappe, U. J., Sahin, M., Giampa, M., et al. (2020). Glioblastoma multiforme: Metabolic differences to peritumoral tissue and IDH-mutated gliomas revealed by mass spectrometry imaging. Neuropathology : official journal of the Japanese Society of Neuropathology, 40(6), 546-558. doi:10.1111/neup.12671
Kampa, J. M., Kellner, U., Marsching, C., Ramallo Guevara, C., Knappe, U. J., Sahin, M., Giampa, M., Niehaus, K., and Bednarz, H. (2020). Glioblastoma multiforme: Metabolic differences to peritumoral tissue and IDH-mutated gliomas revealed by mass spectrometry imaging. Neuropathology : official journal of the Japanese Society of Neuropathology 40, 546-558.
Kampa, J.M., et al., 2020. Glioblastoma multiforme: Metabolic differences to peritumoral tissue and IDH-mutated gliomas revealed by mass spectrometry imaging. Neuropathology : official journal of the Japanese Society of Neuropathology, 40(6), p 546-558.
J.M. Kampa, et al., “Glioblastoma multiforme: Metabolic differences to peritumoral tissue and IDH-mutated gliomas revealed by mass spectrometry imaging.”, Neuropathology : official journal of the Japanese Society of Neuropathology, vol. 40, 2020, pp. 546-558.
Kampa, J.M., Kellner, U., Marsching, C., Ramallo Guevara, C., Knappe, U.J., Sahin, M., Giampa, M., Niehaus, K., Bednarz, H.: Glioblastoma multiforme: Metabolic differences to peritumoral tissue and IDH-mutated gliomas revealed by mass spectrometry imaging. Neuropathology : official journal of the Japanese Society of Neuropathology. 40, 546-558 (2020).
Kampa, Judith Martha, Kellner, Udo, Marsching, Christian, Ramallo Guevara, Carina, Knappe, Ulrich J, Sahin, Mikail, Giampa, Marco, Niehaus, Karsten, and Bednarz, Hanna. “Glioblastoma multiforme: Metabolic differences to peritumoral tissue and IDH-mutated gliomas revealed by mass spectrometry imaging.”. Neuropathology : official journal of the Japanese Society of Neuropathology 40.6 (2020): 546-558.
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