Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against some Pathogenic Yeasts and Enzymes of Metabolic Significance

Tchuenmogne, Marthe Aimée Tchuente; Ngouana, Thierry Kammalac; Gohlke, Sebastian; Kouipou, Rufin M. T.; Aslan, Abdulselam; Kuzu, Muslum; Comakli, Veysel; Demirdag, Ramazan; Ngouela, Silvère A.; Tsamo, Etienne; Sewald, Norbert; Lenta, Bruno N.; Boyom, Fabrice F.

Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against some Pathogenic Yeasts and Enzymes of Metabolic Significance

Tchuenmogne MAT, Ngouana TK, Gohlke S, Kouipou RMT, Aslan A, Kuzu M, Comakli V, Demirdag R, Ngouela SA, Tsamo E, Sewald N, et al. (2016)
Preprints.

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DOI

https://doi.org/10.20944/preprints201611.0023.v1

Autor*in

Tchuenmogne, Marthe Aimée Tchuente; Ngouana, Thierry Kammalac; Gohlke, Sebastian^UniBi; Kouipou, Rufin M. T.; Aslan, Abdulselam; Kuzu, Muslum; Comakli, Veysel; Demirdag, Ramazan; Ngouela, Silvère A.; Tsamo, Etienne; Sewald, Norbert^UniBi ; Lenta, Bruno N.
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Einrichtung

Fakultät für Chemie > Organische Chemie III

Abstract / Bemerkung

The chemical investigation of the anti-yeast methanol extract from the stem bark of Terminalia mantaly led to the isolation of seven compounds: 3-O-methyl-4-O-α-rhamnopyranoside ellagic acid (1), 3-O-mehylellagic acid (2), arjungenin or 2,3,19,23-tetrahydroxyolean-12-en-28-oïc acid (3), arjunglucoside or 2,3,19,23-tetrahydroxyolean-12-en-28-oïc acid glucopyranoside (4), 2α,3α,24-trihydroxyolean-11,13(18)-dien-28-oïc acid (5), stigmasterol (6), stigmasterol 3-O-β-D-glucopyranoside (7). Their structures were established by means of spectroscopic analysis and comparison with published data. Compounds 1-5 were tested in vitro for activity against three pathogenic yeast isolates, Candida albicans, Candida parapsilosis and Candida krusei. The activity of compounds 1, 2 and 4 were comparable to that of the reference compound fluconazole (MIC values below 32 µg/ml) against the three tested yeast isolates. They were also tested for inhibitory properties against four enzymes of metabolic significance: Glucose-6-Phosphate Deshydrogenase (G6PD), human erythrocyte Carbonic anhydrase I and II (hCA I and hCA II), Glutathione S-transferase (GST). Compound 4 showed highly potent inhibitory property against the four tested enzymes with overall IC50 values below 4 µM and inhibitory constant (Ki) <3 µM.

Erscheinungsjahr

2016

Zeitschriftentitel

Preprints

Page URI

https://pub.uni-bielefeld.de/record/2944918

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Tchuenmogne MAT, Ngouana TK, Gohlke S, et al. Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against some Pathogenic Yeasts and Enzymes of Metabolic Significance. Preprints. 2016.

Tchuenmogne, M. A. T., Ngouana, T. K., Gohlke, S., Kouipou, R. M. T., Aslan, A., Kuzu, M., Comakli, V., et al. (2016). Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against some Pathogenic Yeasts and Enzymes of Metabolic Significance. Preprints. doi:10.20944/preprints201611.0023.v1

Tchuenmogne, Marthe Aimée Tchuente, Ngouana, Thierry Kammalac, Gohlke, Sebastian, Kouipou, Rufin M. T., Aslan, Abdulselam, Kuzu, Muslum, Comakli, Veysel, et al. 2016. “Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against some Pathogenic Yeasts and Enzymes of Metabolic Significance”. Preprints.

Tchuenmogne, M. A. T., Ngouana, T. K., Gohlke, S., Kouipou, R. M. T., Aslan, A., Kuzu, M., Comakli, V., Demirdag, R., Ngouela, S. A., Tsamo, E., et al. (2016). Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against some Pathogenic Yeasts and Enzymes of Metabolic Significance. Preprints.

Tchuenmogne, M.A.T., et al., 2016. Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against some Pathogenic Yeasts and Enzymes of Metabolic Significance. Preprints.

M.A.T. Tchuenmogne, et al., “Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against some Pathogenic Yeasts and Enzymes of Metabolic Significance”, Preprints, 2016.

Tchuenmogne, M.A.T., Ngouana, T.K., Gohlke, S., Kouipou, R.M.T., Aslan, A., Kuzu, M., Comakli, V., Demirdag, R., Ngouela, S.A., Tsamo, E., Sewald, N., Lenta, B.N., Boyom, F.F.: Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against some Pathogenic Yeasts and Enzymes of Metabolic Significance. Preprints. (2016).

Tchuenmogne, Marthe Aimée Tchuente, Ngouana, Thierry Kammalac, Gohlke, Sebastian, Kouipou, Rufin M. T., Aslan, Abdulselam, Kuzu, Muslum, Comakli, Veysel, Demirdag, Ramazan, Ngouela, Silvère A., Tsamo, Etienne, Sewald, Norbert, Lenta, Bruno N., and Boyom, Fabrice F. “Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against some Pathogenic Yeasts and Enzymes of Metabolic Significance”. Preprints (2016).

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Compounds from <em>Terminalia mantaly</em> L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against some Pathogenic Yeasts and Enzymes of Metabolic Significance<strong></strong>

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