Norepinephrine is a negative regulator of the adult periventricular neural stem cell niche

Weselek G, Keiner S, Fauser M, Wagenführ L, Müller J, Kaltschmidt B, Brandt MD, Gerlach M, Redecker C, Hermann A, Storch A (2020)
Stem Cells 38(9): 1188-1201.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
OA 5.75 MB
Autor*in
Weselek, Grit; Keiner, Silke; Fauser, Mareike; Wagenführ, Lisa; Müller, Julia; Kaltschmidt, BarbaraUniBi; Brandt, Moritz D.; Gerlach, Manfred; Redecker, Christoph; Hermann, Andreas; Storch, Alexander
Abstract / Bemerkung
The limited proliferative capacity of neuroprogenitor cells (NPCs) within the periventricular germinal niches (PGNs) located caudal of the subventricular zone (SVZ) of the lateral ventricles together with their high proliferation capacity after isolation strongly implicates cell-extrinsic humoral factors restricting NPC proliferation in the hypothalamic and midbrain PGNs. We comparatively examined the effects of norepinephrine (NE) as an endogenous candidate regulator of PGN neurogenesis in the SVZ as well as the periventricular hypothalamus and the periaqueductal midbrain. Histological and neurochemical analyses revealed that the pattern of NE innervation of the adult PGNs is inversely associated with their in vivo NPC proliferation capacity with low NE levels coupled to high NPC proliferation in the SVZ but high NE levels coupled to low NPC proliferation in hypothalamic and midbrain PGNs. Intraventricular infusion of NE decreased NPC proliferation and neurogenesis in the SVZ-olfactory bulb system, while pharmacological NE inhibition increased NPC proliferation and early neurogenesis events in the caudal PGNs. Neurotoxic ablation of NE neurons using the Dsp4-fluoxetine protocol confirmed its inhibitory effects on NPC proliferation. Contrarily, NE depletion largely impairs NPC proliferation within the hippocampus in the same animals. Our data indicate that norepinephrine has opposite effects on the two fundamental neurogenic niches of the adult brain with norepinephrine being a negative regulator of adult periventricular neurogenesis. This knowledge might ultimately lead to new therapeutic approaches to influence neurogenesis in hypothalamus-related metabolic diseases or to stimulate endogenous regenerative potential in neurodegenerative processes such as Parkinson's disease.
Stichworte
Developmental Biology; Molecular Medicine; Cell Biology
Erscheinungsjahr
2020
Zeitschriftentitel
Stem Cells
Band
38
Ausgabe
9
Seite(n)
1188-1201
ISSN
1066-5099
Page URI
https://pub.uni-bielefeld.de/record/2944623

Zitieren

Weselek G, Keiner S, Fauser M, et al. Norepinephrine is a negative regulator of the adult periventricular neural stem cell niche. Stem Cells. 2020;38(9):1188-1201.
Weselek, G., Keiner, S., Fauser, M., Wagenführ, L., Müller, J., Kaltschmidt, B., Brandt, M. D., et al. (2020). Norepinephrine is a negative regulator of the adult periventricular neural stem cell niche. Stem Cells, 38(9), 1188-1201. doi:10.1002/stem.3232
Weselek, Grit, Keiner, Silke, Fauser, Mareike, Wagenführ, Lisa, Müller, Julia, Kaltschmidt, Barbara, Brandt, Moritz D., et al. 2020. “Norepinephrine is a negative regulator of the adult periventricular neural stem cell niche”. Stem Cells 38 (9): 1188-1201.
Weselek, G., Keiner, S., Fauser, M., Wagenführ, L., Müller, J., Kaltschmidt, B., Brandt, M. D., Gerlach, M., Redecker, C., Hermann, A., et al. (2020). Norepinephrine is a negative regulator of the adult periventricular neural stem cell niche. Stem Cells 38, 1188-1201.
Weselek, G., et al., 2020. Norepinephrine is a negative regulator of the adult periventricular neural stem cell niche. Stem Cells, 38(9), p 1188-1201.
G. Weselek, et al., “Norepinephrine is a negative regulator of the adult periventricular neural stem cell niche”, Stem Cells, vol. 38, 2020, pp. 1188-1201.
Weselek, G., Keiner, S., Fauser, M., Wagenführ, L., Müller, J., Kaltschmidt, B., Brandt, M.D., Gerlach, M., Redecker, C., Hermann, A., Storch, A.: Norepinephrine is a negative regulator of the adult periventricular neural stem cell niche. Stem Cells. 38, 1188-1201 (2020).
Weselek, Grit, Keiner, Silke, Fauser, Mareike, Wagenführ, Lisa, Müller, Julia, Kaltschmidt, Barbara, Brandt, Moritz D., Gerlach, Manfred, Redecker, Christoph, Hermann, Andreas, and Storch, Alexander. “Norepinephrine is a negative regulator of the adult periventricular neural stem cell niche”. Stem Cells 38.9 (2020): 1188-1201.
Alle Dateien verfügbar unter der/den folgenden Lizenz(en):
Creative Commons Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International (CC BY-NC-ND 4.0):
Volltext(e)
Name
Access Level
OA Open Access
Zuletzt Hochgeladen
2021-01-25T15:00:14Z
MD5 Prüfsumme
37717e1f4180d3b7ec19282def5a0abc


Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®
Quellen

PMID: 32473039
PubMed | Europe PMC

Suchen in

Google Scholar