Mesomeric form of quaternary indoloquinazoline alkaloid and other constituents from the Cameroonian Rutaceae Araliopsis soyauxii Engl.

Noulala CGT, Fotso GW, Rennert R, Lenta BN, Sewald N, Arnold N, Happi EN, Ngadjui BT (2020)
BIOCHEMICAL SYSTEMATICS AND ECOLOGY 91: UNSP 104050.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
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Autor*in
Noulala, Cedric Guy Tchatchouang; Fotso, Ghislain Wabo; Rennert, Robert; Lenta, Bruno Ndjakou; Sewald, NorbertUniBi ; Arnold, Norbert; Happi, Emmanuel Ngeufa; Ngadjui, Bonaventure Tchaleu
Abstract / Bemerkung
A mesomeric form of quaternary indoloquinazoline alkaloid, soyauxinium chloride (1) was obtained through the chemical investigation of stem bark and roots of Araliopsis soyauxii Engl. [syn. Vepris soyauxii (Engl.) Mziray] (Rutaceae) together with fifteen known compounds, including three furoquinoline alkaloids, three 2-quinolones, two limonoids, two triterpenes, two steroids, a coumarin, an acridone alkaloid, and a flavonoid glycoside. Their structures were established by comprehensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-HR-MS) and by comparison with previously reported data. C-13 NMR data of araliopsinine are also reported here for the first time. The isolated compounds were screened in vitro for their effects on the viability of two different human cancer cell lines, namely prostate PC-3 adenocarcinoma cells and colorectal HT-29 adenocarcinoma cells. However, none of the tested compounds exhibited strong anti-proliferative or cytotoxic activities, to either prostate PC-3 cells or colon HT-29 cells. At 100 mu M, the furoquinoline maculine showed a slightly increased anti-proliferative effect, however, exclusively on HT-29 cells. The chemotaxonomic significance of the isolated compounds has also been discussed.
Stichworte
Araliopsis soyauxii; Rutaceae; Indoloquinazoline; Soyauxinium chloride; Araliopsinine; Chemotaxonomy
Erscheinungsjahr
2020
Zeitschriftentitel
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
Band
91
Art.-Nr.
UNSP 104050
ISSN
0305-1978
eISSN
1873-2925
Page URI
https://pub.uni-bielefeld.de/record/2944503

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Noulala CGT, Fotso GW, Rennert R, et al. Mesomeric form of quaternary indoloquinazoline alkaloid and other constituents from the Cameroonian Rutaceae Araliopsis soyauxii Engl. BIOCHEMICAL SYSTEMATICS AND ECOLOGY. 2020;91: UNSP 104050.
Noulala, C. G. T., Fotso, G. W., Rennert, R., Lenta, B. N., Sewald, N., Arnold, N., Happi, E. N., et al. (2020). Mesomeric form of quaternary indoloquinazoline alkaloid and other constituents from the Cameroonian Rutaceae Araliopsis soyauxii Engl. BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 91, UNSP 104050. doi:10.1016/j.bse.2020.104050
Noulala, C. G. T., Fotso, G. W., Rennert, R., Lenta, B. N., Sewald, N., Arnold, N., Happi, E. N., and Ngadjui, B. T. (2020). Mesomeric form of quaternary indoloquinazoline alkaloid and other constituents from the Cameroonian Rutaceae Araliopsis soyauxii Engl. BIOCHEMICAL SYSTEMATICS AND ECOLOGY 91:UNSP 104050.
Noulala, C.G.T., et al., 2020. Mesomeric form of quaternary indoloquinazoline alkaloid and other constituents from the Cameroonian Rutaceae Araliopsis soyauxii Engl. BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 91: UNSP 104050.
C.G.T. Noulala, et al., “Mesomeric form of quaternary indoloquinazoline alkaloid and other constituents from the Cameroonian Rutaceae Araliopsis soyauxii Engl.”, BIOCHEMICAL SYSTEMATICS AND ECOLOGY, vol. 91, 2020, : UNSP 104050.
Noulala, C.G.T., Fotso, G.W., Rennert, R., Lenta, B.N., Sewald, N., Arnold, N., Happi, E.N., Ngadjui, B.T.: Mesomeric form of quaternary indoloquinazoline alkaloid and other constituents from the Cameroonian Rutaceae Araliopsis soyauxii Engl. BIOCHEMICAL SYSTEMATICS AND ECOLOGY. 91, : UNSP 104050 (2020).
Noulala, Cedric Guy Tchatchouang, Fotso, Ghislain Wabo, Rennert, Robert, Lenta, Bruno Ndjakou, Sewald, Norbert, Arnold, Norbert, Happi, Emmanuel Ngeufa, and Ngadjui, Bonaventure Tchaleu. “Mesomeric form of quaternary indoloquinazoline alkaloid and other constituents from the Cameroonian Rutaceae Araliopsis soyauxii Engl.”. BIOCHEMICAL SYSTEMATICS AND ECOLOGY 91 (2020): UNSP 104050.

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