Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae)

Waleguele CC, Mba’ning BM, Awantu AF, Bankeu JJK, Fongang YSF, Ngouela AS, Tsamo E, Sewald N, Lenta BN, Krause RWM (2020)
Molecules 25(12): 2862.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Waleguele, Christine C.; Mba’ning, Brice M.; Awantu, Angelbert F.; Bankeu, Jean J. K.; Fongang, Yannick S. F.; Ngouela, Augustin S.; Tsamo, Etienne; Sewald, NorbertUniBi ; Lenta, Bruno N.; Krause, Rui W. M.
Abstract / Bemerkung
The MeOH/CH2Cl2 (1:1) extracts of the roots and leaves of Beilschmiedia louisii and B. obscura showed potent antitrypanosomal activity during preliminary screening on Trypanosoma brucei brucei. Phytochemical investigation of these extracts led to the isolation of a mixture of two new endiandric acid derivatives beilschmiedol B (1) and beilschmiedol C (2), and one new phenylalkene obscurene A (3) together with twelve known compounds (4–15). In addition, four new derivatives (11a–11d) were synthesized from compound 11. Their structures were elucidated based on their NMR and MS data. Compounds 5, 6, and 7 were isolated for the first time from the Beilschmiedia genus. Additionally, the NMR data of compound 4 are given here for the first time. The isolates were evaluated for their antitrypanosomal and antimalarial activities against Tb brucei and the Plasmodium falciparum chloroquine-resistant strain Pf3D7 in vitro, respectively. From the tested compounds, the mixture of new compounds 1 and 2 exhibited the most potent antitrypanosomal activity in vitro with IC50 value of 4.91 μM.
Stichworte
Lauraceae; Beilschmiedia obscura; Beilschmiedia louisii; endiandric acid; antitrypanosomal activity
Erscheinungsjahr
2020
Zeitschriftentitel
Molecules
Band
25
Ausgabe
12
Art.-Nr.
2862
eISSN
1420-3049
Page URI
https://pub.uni-bielefeld.de/record/2944301

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Waleguele CC, Mba’ning BM, Awantu AF, et al. Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae). Molecules. 2020;25(12): 2862.
Waleguele, C. C., Mba’ning, B. M., Awantu, A. F., Bankeu, J. J. K., Fongang, Y. S. F., Ngouela, A. S., Tsamo, E., et al. (2020). Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae). Molecules, 25(12), 2862. doi:10.3390/molecules25122862
Waleguele, C. C., Mba’ning, B. M., Awantu, A. F., Bankeu, J. J. K., Fongang, Y. S. F., Ngouela, A. S., Tsamo, E., Sewald, N., Lenta, B. N., and Krause, R. W. M. (2020). Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae). Molecules 25:2862.
Waleguele, C.C., et al., 2020. Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae). Molecules, 25(12): 2862.
C.C. Waleguele, et al., “Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae)”, Molecules, vol. 25, 2020, : 2862.
Waleguele, C.C., Mba’ning, B.M., Awantu, A.F., Bankeu, J.J.K., Fongang, Y.S.F., Ngouela, A.S., Tsamo, E., Sewald, N., Lenta, B.N., Krause, R.W.M.: Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae). Molecules. 25, : 2862 (2020).
Waleguele, Christine C., Mba’ning, Brice M., Awantu, Angelbert F., Bankeu, Jean J. K., Fongang, Yannick S. F., Ngouela, Augustin S., Tsamo, Etienne, Sewald, Norbert, Lenta, Bruno N., and Krause, Rui W. M. “Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae)”. Molecules 25.12 (2020): 2862.
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