Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae)

Waleguele, Christine C.; Mba’ning, Brice M.; Awantu, Angelbert F.; Bankeu, Jean J. K.; Fongang, Yannick S. F.; Ngouela, Augustin S.; Tsamo, Etienne; Sewald, Norbert; Lenta, Bruno N.; Krause, Rui W. M.

Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae)

Waleguele CC, Mba’ning BM, Awantu AF, Bankeu JJK, Fongang YSF, Ngouela AS, Tsamo E, Sewald N, Lenta BN, Krause RWM (2020)
Molecules 25(12): 2862.

Zeitschriftenaufsatz | Veröffentlicht | Englisch

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DOI

https://doi.org/10.3390/molecules25122862

URN

urn:nbn:de:0070-pub-29443011

Autor*in

Waleguele, Christine C.; Mba’ning, Brice M.; Awantu, Angelbert F.; Bankeu, Jean J. K.; Fongang, Yannick S. F.; Ngouela, Augustin S.; Tsamo, Etienne; Sewald, Norbert^UniBi ; Lenta, Bruno N.; Krause, Rui W. M.

Einrichtung

Fakultät für Chemie > Organische Chemie III

Abstract / Bemerkung

The MeOH/CH2Cl2 (1:1) extracts of the roots and leaves of Beilschmiedia louisii and B. obscura showed potent antitrypanosomal activity during preliminary screening on Trypanosoma brucei brucei. Phytochemical investigation of these extracts led to the isolation of a mixture of two new endiandric acid derivatives beilschmiedol B (1) and beilschmiedol C (2), and one new phenylalkene obscurene A (3) together with twelve known compounds (4–15). In addition, four new derivatives (11a–11d) were synthesized from compound 11. Their structures were elucidated based on their NMR and MS data. Compounds 5, 6, and 7 were isolated for the first time from the Beilschmiedia genus. Additionally, the NMR data of compound 4 are given here for the first time. The isolates were evaluated for their antitrypanosomal and antimalarial activities against Tb brucei and the Plasmodium falciparum chloroquine-resistant strain Pf3D7 in vitro, respectively. From the tested compounds, the mixture of new compounds 1 and 2 exhibited the most potent antitrypanosomal activity in vitro with IC50 value of 4.91 μM.

Stichworte

Lauraceae; Beilschmiedia obscura; Beilschmiedia louisii; endiandric acid; antitrypanosomal activity

Erscheinungsjahr

2020

Zeitschriftentitel

Molecules

Band

Ausgabe

Art.-Nr.

2862

Urheberrecht / Lizenzen

Creative Commons Namensnennung 4.0 International Public License (CC-BY 4.0)

eISSN

1420-3049

Finanzierungs-Informationen

Open-Access-Publikationskosten wurden durch die Deutsche Forschungsgemeinschaft und die Universität Bielefeld gefördert.

Page URI

https://pub.uni-bielefeld.de/record/2944301

Zitieren

Waleguele CC, Mba’ning BM, Awantu AF, et al. Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae). Molecules. 2020;25(12): 2862.

Waleguele, C. C., Mba’ning, B. M., Awantu, A. F., Bankeu, J. J. K., Fongang, Y. S. F., Ngouela, A. S., Tsamo, E., et al. (2020). Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae). Molecules, 25(12), 2862. doi:10.3390/molecules25122862

Waleguele, Christine C., Mba’ning, Brice M., Awantu, Angelbert F., Bankeu, Jean J. K., Fongang, Yannick S. F., Ngouela, Augustin S., Tsamo, Etienne, Sewald, Norbert, Lenta, Bruno N., and Krause, Rui W. M. 2020. “Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae)”. Molecules 25 (12): 2862.

Waleguele, C. C., Mba’ning, B. M., Awantu, A. F., Bankeu, J. J. K., Fongang, Y. S. F., Ngouela, A. S., Tsamo, E., Sewald, N., Lenta, B. N., and Krause, R. W. M. (2020). Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae). Molecules 25:2862.

Waleguele, C.C., et al., 2020. Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae). Molecules, 25(12): 2862.

C.C. Waleguele, et al., “Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae)”, Molecules, vol. 25, 2020, : 2862.

Waleguele, C.C., Mba’ning, B.M., Awantu, A.F., Bankeu, J.J.K., Fongang, Y.S.F., Ngouela, A.S., Tsamo, E., Sewald, N., Lenta, B.N., Krause, R.W.M.: Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae). Molecules. 25, : 2862 (2020).

Waleguele, Christine C., Mba’ning, Brice M., Awantu, Angelbert F., Bankeu, Jean J. K., Fongang, Yannick S. F., Ngouela, Augustin S., Tsamo, Etienne, Sewald, Norbert, Lenta, Bruno N., and Krause, Rui W. M. “Antiparasitic Constituents of Beilschmiedia louisii and Beilschmiedia obscura and Some Semisynthetic Derivatives (Lauraceae)”. Molecules 25.12 (2020): 2862.

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