A-type doubly linked proanthocyanidin trimer and other metabolites from Canthium venosum fruits, and their biological activities

Dongmo AK, Nono RN, Kaaniche F, Mawabo IK, Frese M, Chouna JR, Nkenfou CN, Lenta BN, Ngnokam D, Nkeng-Efouet-Alango P, Sewald N (2020)
PHYTOCHEMISTRY LETTERS 36: 134-138.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Dongmo, Appolinaire Kene; Nono, Raymond Ngansop; Kaaniche, Fatma; Mawabo, Isabelle Kamga; Frese, MarcelUniBi; Chouna, Jean Rodolphe; Nkenfou, Celine Nguefeu; Lenta, Bruno Ndjakou; Ngnokam, David; Nkeng-Efouet-Alango, Pepin; Sewald, NorbertUniBi
Abstract / Bemerkung
Phytochemical investigation of Canthium venosum fruits led to the isolation of a new doubly linked A-type proanthocyanidin trimer: epicatechin-(2 beta -> O -> 7, 4 beta -> 8)-catechin-(5 -> O -> 2 beta, 6 -> 4 beta)-epicatechin [venosumtannin A-1 (1)], along with twenty known compounds 2-21. Allyl (9a) and acetyl (9b) derivatives of 9 were prepared. The structures of compounds were established using comprehensive spectroscopic analysis including 1D NMR, 2D NMR (COSY, HMQC, HMBC, and NOESY) and circular dichroism (CD), and by comparison with the corresponding literature data. The antioxidant, cytotoxic, acetylcholinesterase and antibacterial activities of some of the isolated compounds were investigated. In the acetylcholinesterase inhibitory activity test, compounds 2 and 9 (IC50: 0.03 +/- 1.22x10(-3) and 0.04 +/- 1.23x10(-3) mu M) were more active than the references (eserine and tacrine; IC50: 0.77 +/- 1.84x10(-3) and 0.15 +/- 1.04x10(-3) mu M respectively).
Stichworte
Canthium venosum; Doubly linked A-type proanthocyanidin; Cytotoxic; Antioxidant; Acetylcholinesterase; Antibacterial activity
Erscheinungsjahr
2020
Zeitschriftentitel
PHYTOCHEMISTRY LETTERS
Band
36
Seite(n)
134-138
ISSN
1874-3900
eISSN
1876-7486
Page URI
https://pub.uni-bielefeld.de/record/2943815

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Dongmo AK, Nono RN, Kaaniche F, et al. A-type doubly linked proanthocyanidin trimer and other metabolites from Canthium venosum fruits, and their biological activities. PHYTOCHEMISTRY LETTERS. 2020;36:134-138.
Dongmo, A. K., Nono, R. N., Kaaniche, F., Mawabo, I. K., Frese, M., Chouna, J. R., Nkenfou, C. N., et al. (2020). A-type doubly linked proanthocyanidin trimer and other metabolites from Canthium venosum fruits, and their biological activities. PHYTOCHEMISTRY LETTERS, 36, 134-138. doi:10.1016/j.phytol.2020.01.020
Dongmo, A. K., Nono, R. N., Kaaniche, F., Mawabo, I. K., Frese, M., Chouna, J. R., Nkenfou, C. N., Lenta, B. N., Ngnokam, D., Nkeng-Efouet-Alango, P., et al. (2020). A-type doubly linked proanthocyanidin trimer and other metabolites from Canthium venosum fruits, and their biological activities. PHYTOCHEMISTRY LETTERS 36, 134-138.
Dongmo, A.K., et al., 2020. A-type doubly linked proanthocyanidin trimer and other metabolites from Canthium venosum fruits, and their biological activities. PHYTOCHEMISTRY LETTERS, 36, p 134-138.
A.K. Dongmo, et al., “A-type doubly linked proanthocyanidin trimer and other metabolites from Canthium venosum fruits, and their biological activities”, PHYTOCHEMISTRY LETTERS, vol. 36, 2020, pp. 134-138.
Dongmo, A.K., Nono, R.N., Kaaniche, F., Mawabo, I.K., Frese, M., Chouna, J.R., Nkenfou, C.N., Lenta, B.N., Ngnokam, D., Nkeng-Efouet-Alango, P., Sewald, N.: A-type doubly linked proanthocyanidin trimer and other metabolites from Canthium venosum fruits, and their biological activities. PHYTOCHEMISTRY LETTERS. 36, 134-138 (2020).
Dongmo, Appolinaire Kene, Nono, Raymond Ngansop, Kaaniche, Fatma, Mawabo, Isabelle Kamga, Frese, Marcel, Chouna, Jean Rodolphe, Nkenfou, Celine Nguefeu, Lenta, Bruno Ndjakou, Ngnokam, David, Nkeng-Efouet-Alango, Pepin, and Sewald, Norbert. “A-type doubly linked proanthocyanidin trimer and other metabolites from Canthium venosum fruits, and their biological activities”. PHYTOCHEMISTRY LETTERS 36 (2020): 134-138.