Antioxidant norbergenin derivatives from the leaves of Diospyros gilletii De Wild (Ebenaceae)

Tameye NSJ, Akak CM, Happi Mouthe G, Frese M, Stammler H-G, Neumann B, Lenta BN, Sewald N, Nkengfack AE (2020)
PHYTOCHEMISTRY LETTERS 36: 63-67.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Tameye, Nathalie S. Jouwa; Akak, Carine Mvot; Happi Mouthe, GervaisUniBi; Frese, MarcelUniBi; Stammler, Hans-GeorgUniBi; Neumann, BeateUniBi; Lenta, Bruno Ndjakou; Sewald, NorbertUniBi ; Nkengfack, Augustin E.
Abstract / Bemerkung
Two new norbergenin derivatives, 4-O-p-hydroxybenzoylnorbergenin (1) and 11-O-(E)-cinnamoylnorbergenin (2), were isolated from the leaves of Diospyros gilletii De Wild along with nine known compounds, including norbergenin (3), 4-O-galloylnorbergenin (4), betulin (5), betulinic acid (6), lupeol (7), ursolic acid (8), corosolic acid (9), beta-sitosterol (10) and quercitol (11). Their structures were elucidated from the analysis of their 1D and 2D H-1 and C-13 NMR spectral data in conjunction with mass spectrometry. Single-crystal X-ray diffraction technique unambiguously established the structure of compound (1). The antimicrobial properties of the eleven compounds isolated were investigated as well as the antioxidant activity of the norbergenin derivatives (1-4). The results obtained showed that none of those compounds displayed antimicrobial activity at 0.5 mu g/ml whereas norbergenin derivatives exhibited noteworthy antioxidant property with IC50 values ranging from 8.2 mu g/ml to 41.6 mu g/ml.
Stichworte
Diospyros gilletii; Ebenaceae; Norbergenin; Antioxidant; X-ray crystal; structure
Erscheinungsjahr
2020
Zeitschriftentitel
PHYTOCHEMISTRY LETTERS
Band
36
Seite(n)
63-67
ISSN
1874-3900
eISSN
1876-7486
Page URI
https://pub.uni-bielefeld.de/record/2943814

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Tameye NSJ, Akak CM, Happi Mouthe G, et al. Antioxidant norbergenin derivatives from the leaves of Diospyros gilletii De Wild (Ebenaceae). PHYTOCHEMISTRY LETTERS. 2020;36:63-67.
Tameye, N. S. J., Akak, C. M., Happi Mouthe, G., Frese, M., Stammler, H. - G., Neumann, B., Lenta, B. N., et al. (2020). Antioxidant norbergenin derivatives from the leaves of Diospyros gilletii De Wild (Ebenaceae). PHYTOCHEMISTRY LETTERS, 36, 63-67. doi:10.1016/j.phytol.2020.01.012
Tameye, N. S. J., Akak, C. M., Happi Mouthe, G., Frese, M., Stammler, H. - G., Neumann, B., Lenta, B. N., Sewald, N., and Nkengfack, A. E. (2020). Antioxidant norbergenin derivatives from the leaves of Diospyros gilletii De Wild (Ebenaceae). PHYTOCHEMISTRY LETTERS 36, 63-67.
Tameye, N.S.J., et al., 2020. Antioxidant norbergenin derivatives from the leaves of Diospyros gilletii De Wild (Ebenaceae). PHYTOCHEMISTRY LETTERS, 36, p 63-67.
N.S.J. Tameye, et al., “Antioxidant norbergenin derivatives from the leaves of Diospyros gilletii De Wild (Ebenaceae)”, PHYTOCHEMISTRY LETTERS, vol. 36, 2020, pp. 63-67.
Tameye, N.S.J., Akak, C.M., Happi Mouthe, G., Frese, M., Stammler, H.-G., Neumann, B., Lenta, B.N., Sewald, N., Nkengfack, A.E.: Antioxidant norbergenin derivatives from the leaves of Diospyros gilletii De Wild (Ebenaceae). PHYTOCHEMISTRY LETTERS. 36, 63-67 (2020).
Tameye, Nathalie S. Jouwa, Akak, Carine Mvot, Happi Mouthe, Gervais, Frese, Marcel, Stammler, Hans-Georg, Neumann, Beate, Lenta, Bruno Ndjakou, Sewald, Norbert, and Nkengfack, Augustin E. “Antioxidant norbergenin derivatives from the leaves of Diospyros gilletii De Wild (Ebenaceae)”. PHYTOCHEMISTRY LETTERS 36 (2020): 63-67.