Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study

Geisler R, Prévost S, Dattani R, Hellweg T (2020)
Crystals 10(5): 401.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Geisler, Ramsia; Prévost, Sylvain; Dattani, Rajeev; Hellweg, ThomasUniBi
Abstract / Bemerkung
β -aescin is a versatile biosurfactant extracted from the seeds of the horse chestnut tree Aesculus hippocastanum with anti-cancer potential and is commonly used in the food and pharmaceutical and cosmetic industries. In this article, wide-angle X-ray scattering (WAXS) is used in order to study the modifications of the structural parameters at the molecular scale of lipid bilayers in the form of bicelles composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and the triterpenoid saponin β -aescin. In particular, the impact on the cooperative phase transition and the structural parameters of the DMPC bilayers at different compositions and temperatures is of special interest. Moreover, we show how cholesterol and the non-steroidal anti-inflammatory drug (NSAID) ibuprofen modulate the structural parameters of the β -aescin-DMPC assemblies on a molecular scale. Ibuprofen and cholesterol interact with different parts of the bilayer, namely the head-region in the former and the tail-region in the latter case allowing for specific molecular packing and phase formation in the binary and ternary mixtures.
Stichworte
Inorganic Chemistry; General Materials Science; General Chemical Engineering; Condensed Matter Physics
Erscheinungsjahr
2020
Zeitschriftentitel
Crystals
Band
10
Ausgabe
5
Art.-Nr.
401
ISSN
2073-4352
Page URI
https://pub.uni-bielefeld.de/record/2943467

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Geisler R, Prévost S, Dattani R, Hellweg T. Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study. Crystals. 2020;10(5): 401.
Geisler, R., Prévost, S., Dattani, R., & Hellweg, T. (2020). Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study. Crystals, 10(5), 401. doi:10.3390/cryst10050401
Geisler, R., Prévost, S., Dattani, R., and Hellweg, T. (2020). Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study. Crystals 10:401.
Geisler, R., et al., 2020. Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study. Crystals, 10(5): 401.
R. Geisler, et al., “Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study”, Crystals, vol. 10, 2020, : 401.
Geisler, R., Prévost, S., Dattani, R., Hellweg, T.: Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study. Crystals. 10, : 401 (2020).
Geisler, Ramsia, Prévost, Sylvain, Dattani, Rajeev, and Hellweg, Thomas. “Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study”. Crystals 10.5 (2020): 401.
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2020-07-01T15:43:50Z
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