Twin Research in the Post-Genomic Era: Dissecting the Pathophysiological Effects of Adversity and the Social Environment

Turner JD, D'Ambrosio C, Vögele C, Diewald M (2020)
International Journal of Molecular Sciences 21(9): 3142.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Autor*in
Turner, Jonathan D; D'Ambrosio, Conchita; Vögele, Claus; Diewald, MartinUniBi
Abstract / Bemerkung
The role of twins in research is evolving as we move further into the post-genomic era. With the re-definition of what a gene is, it is becoming clear that biological family members who share a specific genetic variant may well not have a similar risk for future disease. This has somewhat invalidated the prior rationale for twin studies. Case co-twin study designs, however, are slowly emerging as the ideal tool to identify both environmentally induced epigenetic marks and epigenetic disease-associated processes. Here, we propose that twin lives are not as identical as commonly assumed and that the case co-twin study design can be used to investigate the effects of the adult social environment. We present the elements in the (social) environment that are likely to affect the epigenome and measures in which twins may diverge. Using data from the German TwinLife registry, we confirm divergence in both the events that occur and the salience for the individual start as early as age 11. Case co-twin studies allow for the exploitation of these divergences, permitting the investigation of the role of not only the adult social environment, but also the salience of an event or environment for the individual, in determining lifelong health trajectories. In cases like social adversity where it is clearly not possible to perform a randomised-controlled trial, we propose that the case co-twin study design is the most rigorous manner with which to investigate epigenetic mechanisms encoding environmental exposure. The role of the case co-twin design will continue to evolve, as we argue that it will permit causal inference from observational data.
Stichworte
twins; epigenetics; post-genomics; DNA methylation; early-life environment; epigenetic epidemiology; social adversity; socioeconomic status
Erscheinungsjahr
2020
Zeitschriftentitel
International Journal of Molecular Sciences
Band
21
Ausgabe
9
Art.-Nr.
3142
ISSN
1422-0067
Page URI
https://pub.uni-bielefeld.de/record/2943422

Zitieren

Turner JD, D'Ambrosio C, Vögele C, Diewald M. Twin Research in the Post-Genomic Era: Dissecting the Pathophysiological Effects of Adversity and the Social Environment. International Journal of Molecular Sciences. 2020;21(9): 3142.
Turner, J. D., D'Ambrosio, C., Vögele, C., & Diewald, M. (2020). Twin Research in the Post-Genomic Era: Dissecting the Pathophysiological Effects of Adversity and the Social Environment. International Journal of Molecular Sciences, 21(9), 3142. doi:10.3390/ijms21093142
Turner, J. D., D'Ambrosio, C., Vögele, C., and Diewald, M. (2020). Twin Research in the Post-Genomic Era: Dissecting the Pathophysiological Effects of Adversity and the Social Environment. International Journal of Molecular Sciences 21:3142.
Turner, J.D., et al., 2020. Twin Research in the Post-Genomic Era: Dissecting the Pathophysiological Effects of Adversity and the Social Environment. International Journal of Molecular Sciences, 21(9): 3142.
J.D. Turner, et al., “Twin Research in the Post-Genomic Era: Dissecting the Pathophysiological Effects of Adversity and the Social Environment”, International Journal of Molecular Sciences, vol. 21, 2020, : 3142.
Turner, J.D., D'Ambrosio, C., Vögele, C., Diewald, M.: Twin Research in the Post-Genomic Era: Dissecting the Pathophysiological Effects of Adversity and the Social Environment. International Journal of Molecular Sciences. 21, : 3142 (2020).
Turner, Jonathan D, D'Ambrosio, Conchita, Vögele, Claus, and Diewald, Martin. “Twin Research in the Post-Genomic Era: Dissecting the Pathophysiological Effects of Adversity and the Social Environment”. International Journal of Molecular Sciences 21.9 (2020): 3142.

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 32365612
PubMed | Europe PMC

Suchen in

Google Scholar